2-(2,2,2-Trifluoroethoxy)phenol
- CAS No.
- 160968-99-0
- Chemical Name:
- 2-(2,2,2-Trifluoroethoxy)phenol
- Synonyms
- 2-(2,2,2-Trifluoroethoxy)phenol;Phenol, 2-(2,2,2-trifluoroethoxy)-;2,2,2-Trifluoro-2'-hydroxyphenetole
- CBNumber:
- CB82462099
- Molecular Formula:
- C8H7F3O2
- Molecular Weight:
- 192.14
- MDL Number:
- MFCD11181824
- MOL File:
- 160968-99-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-(2,2,2-Trifluoroethoxy)phenol | TRC-T790190-25G | 25g | $604 |
| 2-(2,2,2-Trifluoroethoxy)phenol | TRC-T790190-2.5G | 2.5g | $154 |
| 2-(2,2,2-Trifluoroethoxy)phenol | TRC-T790190-10G | 10g | $307 |
| 2-(2,2,2-Trifluoroethoxy)phenol >98% | PC49190 | 1g | $21 |
| 2-(2,2,2-Trifluoroethoxy)phenol >98% | PC49190 | 5g | $22 |
| More product size | |||
| Melting point | 49-50 ºC |
|---|---|
| Boiling point | 202 ºC |
| Density | 1.327 |
| Flash point | 102 ºC |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.22±0.30(Predicted) |
| color | Off-White to Pale Grey |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2907290090 |
2-(2,2,2-Trifluoroethoxy)phenol price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-T790190-25G | 2-(2,2,2-Trifluoroethoxy)phenol | 160968-99-0 | 25g | $604 | 2026-06-03 | Buy |
| TRC | TRC-T790190-2.5G | 2-(2,2,2-Trifluoroethoxy)phenol | 160968-99-0 | 2.5g | $154 | 2026-06-03 | Buy |
| TRC | TRC-T790190-10G | 2-(2,2,2-Trifluoroethoxy)phenol | 160968-99-0 | 10g | $307 | 2026-06-03 | Buy |
| Apolloscientific | PC49190 | 2-(2,2,2-Trifluoroethoxy)phenol >98% | 160968-99-0 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC49190 | 2-(2,2,2-Trifluoroethoxy)phenol >98% | 160968-99-0 | 5g | $22 | 2026-06-04 | Buy |
2-(2,2,2-Trifluoroethoxy)phenol Chemical Properties,Uses,Production
Uses
2-(2,2,2-Trifluoroethoxy)phenol is a reactant used for the preparation of phenyl acetate compounds with short sedative and hypnotic effect.
Synthesis
106854-74-4
160968-99-0
GENERAL STEPS: A 1M solution of boron tribromide (30mL, 0.03mol) in dichloromethane was slowly added dropwise to a solution of 1-methoxy-2-(2,2,2-trifluoroethoxy)benzene (4.3g, 0.02mol) in anhydrous dichloromethane (50mL) at -20°C. The reaction was quenched by addition of excess saturated aqueous sodium bicarbonate (40mL). After the reaction mixture was naturally warmed to room temperature, the reaction was quenched by the addition of excess saturated aqueous sodium bicarbonate solution (40 mL). The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product obtained was sufficiently pure (98% yield) to be used directly in the subsequent reaction. The product was a yellow oil (3.8 g) and UPLC/MS analysis showed a purity of 99% with a retention time of tR = 5.37 min. molecular formula C8H7F3O2, molecular weight 192.14, single isotope mass 192.04, [M+H]- m/z 191.0. 1H-NMR (300 MHz, CDCl3) δ 4.36 (q, J = 8.4 Hz, 2H, O-CH2-CF3), 6.81-7.11 (m, 4H, Ar-H), 9.72 (br.s., 1H, OH).13C-NMR (75 MHz, CDCl3) δ 56.2, 68.1, 119.2, 121.5, 122.4, 123.7, 126.4, 127.3, 136.4.
References
[1] Molecules, 2018, vol. 23, # 9,
[2] Patent: US5387603, 1995, A
[3] Patent: WO2011/30356, 2011, A2. Location in patent: Page/Page column 23
[4] Patent: WO2011/101864, 2011, A1. Location in patent: Page/Page column 21-22
[5] Patent: US2012/165548, 2012, A1. Location in patent: Page/Page column 11
2-(2,2,2-Trifluoroethoxy)phenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
View Lastest Price from 2-(2,2,2-Trifluoroethoxy)phenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-02 | 2-(2,2,2-Trifluoroethoxy)phenol
160968-99-0
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2-(2,2,2-Trifluoroethoxy)phenol
160968-99-0
- $7.00
- 99%
- Career Henan Chemical Co
