Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Ethyl 2,4-dichloronicotinate

Ethyl 2,4-dichloronicotinate

Ethyl 2,4-dichloronicotinate Structure
Ethyl 2,4-dichloronicotinate structure
CAS No.
62022-04-2
Chemical Name:
Ethyl 2,4-dichloronicotinate
Synonyms
Ethyl 2,4-dichloronicotinate;2,4-Dichloro-nicotinic acid ethyl ester;2,4-dichloro-5-ethylpyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2,4-dichloro-, ethyl ester
CBNumber:
CB82481371
Molecular Formula:
C8H7Cl2NO2
Molecular Weight:
220.05
MDL Number:
MFCD12407388
MOL File:
62022-04-2.mol
MSDS File:
SDS
Last updated:2026-07-28 20:33:27
Request For Quotation

Ethyl 2,4-dichloronicotinate Properties

Boiling point 281.941±35.00 °C(Press: 760.00 Torr)(predicted)
Density 1.367±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -1.240±0.10(predicted)
Appearance Colorless to light yellow Liquid
InChI InChI=1S/C8H7Cl2NO2/c1-2-13-8(12)6-5(9)3-4-11-7(6)10/h3-4H,2H2,1H3
InChIKey KMFWUAUMIFXMBF-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC(Cl)=C1C(OCC)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HazardClass  IRRITANT
HS Code  2933399990

Ethyl 2,4-dichloronicotinate price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR303797 Ethyl 2,4-dichloronicotinate 98% 62022-04-2 250mg $21 2026-06-04 Buy
Apolloscientific OR303797 Ethyl 2,4-dichloronicotinate 98% 62022-04-2 1g $28 2026-06-04 Buy
Apolloscientific OR303797 Ethyl 2,4-dichloronicotinate 98% 62022-04-2 5g $134 2026-06-04 Buy
Apolloscientific OR303797 Ethyl 2,4-dichloronicotinate 98% 62022-04-2 25g $564 2026-06-04 Buy
Apolloscientific OR303797 Ethyl 2,4-dichloronicotinate 98% 62022-04-2 100g $2140 2026-06-04 Buy
Product number Packaging Price Buy
OR303797 250mg $21 Buy
OR303797 1g $28 Buy
OR303797 5g $134 Buy
OR303797 25g $564 Buy
OR303797 100g $2140 Buy

Ethyl 2,4-dichloronicotinate Chemical Properties,Uses,Production

Synthesis

2,4-Dichloropyridine

26452-80-2

Ethyl 2,4-dichloronicotinate

62022-04-2

To a solution of tetrahydrofuran (THF, 40 mL) containing diisopropylamine (2.4 mL, 16.9 mmol) was slowly added n-butyllithium (10.6 mL, 16.9 mmol, 1.6 M hexane solution) at -78 °C and protected by an inert atmosphere and the reaction was stirred for 15 min. Maintaining the temperature at -78 °C, 2,4-dichloropyridine (1.8 mL, 16.9 mmol) was added dropwise and the reaction mixture continued to be stirred at -78 °C for 2 hours. Subsequently, ethyl cyanoformate (4.0 mL, 40.4 mmol) was added and the reaction mixture continued to be stirred at -78 °C for 1 h before slowly warming up to room temperature. The reaction mixture was partitioned with water and ethyl acetate to separate the organic layer. The organic layer was washed sequentially with saturated sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography (solid phase extraction on silica gel, gradient elution with pentane:ether from 1:0 to 4:1) to afford ethyl 2,4-dichloronicotinate as a colorless oil (1.6 g, 43% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 8.34 (1H, d, J = 5.4 Hz), 7.33 (1H, d, J = 5.4 Hz), 4.49 (2H, q, J = 7.1 Hz), 1.43 (3H, t, J = 7.1 Hz).

References

[1] Patent: WO2008/24725, 2008, A1. Location in patent: Page/Page column 106-107

Ethyl 2,4-dichloronicotinate Preparation Products And Raw materials

Raw materials

2,4-Dichloropyridine Diisopropylamine petroleum ether 40 60 Tetrahydrofuran n-Butyllithium

Preparation Products

Ethyl 2,4-dichloronicotinate Suppliers

Global( 69)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangyin Lesen Biotechnology Co., Ltd. 18961626312 125393839@qq.com China 228 58
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
SynAsst Chemical. 021-60343070 China 12731 55
Nanjing Raise Pharmatech Co., Ltd. 025-58649566 15005191108 sales@njboyuanchem.com China 113 60
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189;18621755571 mychess007@163.com China 1994 55
ShangHai Movin Pharmaceutical Co., Ltd. 13681854265 info@moenpharm.com China 488 55
Yancheng KangdiSen Pharmaceutical Co., Ltd. 13812573443;18052965989 tongbenwan22@163.com China 1975 55
Supplier Advantage
Jiangyin Lesen Biotechnology Co., Ltd. 58
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shanghai Topbiochem Technology Co., Ltd 58
SynAsst Chemical. 55
Nanjing Raise Pharmatech Co., Ltd. 60
Bide Pharmatech Ltd. 60
ShangHai KenEn Chemical Technology Co., Ltd. 55
ShangHai Movin Pharmaceutical Co., Ltd. 55
Yancheng KangdiSen Pharmaceutical Co., Ltd. 55

View Lastest Price from Ethyl 2,4-dichloronicotinate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 2,4-dichloronicotinate pictures 2026-08-13 Ethyl 2,4-dichloronicotinate
62022-04-2
 1G 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.
Ethyl 2,4-dichloronicotinate pictures 2025-04-04 Ethyl 2,4-dichloronicotinate
62022-04-2
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

Ethyl 2,4-dichloronicotinate Spectrum

Ethyl 2,4-dichloronicotinate(62022-04-2)1HNMR

62022-04-2(Ethyl 2,4-dichloronicotinate)Related Search:

Ethyl 2,5-dichloro-3-ethoxybenzoate Ethyl 2-chloro-3-fluoro-6-methoxybenzoate Ethyl 2-chloro-4-fluoro-3-formylbenzoate Ethyl 2-bromo-4-fluoro-3-methoxybenzoate Ethyl 2-bromo-3,4-dichlorobenzoate
Ethyl 2-chloro-3-methoxy-5-methylbenzoate Ethyl 2,3-dibromo-5-methylbenzoate Ethyl 2,4-difluoro-5-hydroxybenzoate ETHYL 2-BROMO-3-METHYLBENZOATE Ethyl 2-chloro-3-methylbenzoate
Ethyl 2,3,4-trimethoxybenzoate Ethyl 2-bromo-4-ethoxybenzoate Ethyl 2-chloro-5-formylbenzoate Ethyl 2-chloro-4-fluoro-5-methylbenzoate Ethyl 2-chloro-4-fluoro-6-(trifluoromethyl)benzoate
Ethyl 2-chloro-3-fluoro-4-isopropoxybenzoate ETHYL 2,4-DICHLORO-5-FLUOROBENZOATE

1of4

Ethyl 2,4-dichloronicotinate 2,4-dichloro-5-ethylpyridine-3-carboxylic acid 3-Pyridinecarboxylic acid, 2,4-dichloro-, ethyl ester 2,4-Dichloro-nicotinic acid ethyl ester 62022-04-2