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ChemicalBook >> CAS DataBase List >>2-Amino-4,6-dichloro-nicotinicacidmethylester

2-Amino-4,6-dichloro-nicotinicacidmethylester

2-Amino-4,6-dichloro-nicotinicacidmethylester Structure
2-Amino-4,6-dichloro-nicotinicacidmethylester structure
CAS No.
1044872-40-3
Chemical Name:
2-Amino-4,6-dichloro-nicotinicacidmethylester
Synonyms
Methyl 2-aMino-4,6-dichloronicotinate;3-Pyri;2-amino-4,6-dichloro-, methyl ester;2-Amino-4,6-dichloro-nicotinicacidmethylester;2-Amino-2,4-Dichloronicotinic acid methyl ester;Methyl 2-amino-4,6-dichloropyridine-3-carboxylate;2-Amino-4,6-dichloropyridine-3-carboxylic acid methyl ester;3-Pyridinecarboxylicacid, 2-amino-4,6-dichloro-, methyl ester;3-pyridinecarboxylic acid, 2-amino-4,6-dichloro-, methyl ester;3-Pyridinecarboxylicacid, 2-amino-4,6-dichloro-, methyl este...
CBNumber:
CB82489645
Molecular Formula:
C7H6Cl2N2O2
Molecular Weight:
221.04
MDL Number:
MFCD16660199
MOL File:
1044872-40-3.mol
MSDS File:
SDS
Last updated:2026-05-28 04:16:57
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2-Amino-4,6-dichloro-nicotinicacidmethylester Properties

Boiling point 319.1±37.0 °C(Predicted)
Density 1.506
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka -0.40±0.50(Predicted)
Appearance Light yellow to orange Solid
InChI InChI=1S/C7H6Cl2N2O2/c1-13-7(12)5-3(8)2-4(9)11-6(5)10/h2H,1H3,(H2,10,11)
InChIKey HJZKXHRUERDKKA-UHFFFAOYSA-N
SMILES C1(N)=NC(Cl)=CC(Cl)=C1C(OC)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2-Amino-4,6-dichloro-nicotinicacidmethylester price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FM146286 Methyl 2-amino-4,6-dichloropyridine-3-carboxylate 1044872-40-3 5g $900 2026-06-04 Buy
Biosynth FM146286 Methyl 2-amino-4,6-dichloropyridine-3-carboxylate 1044872-40-3 2g $900 2026-06-04 Buy
Biosynth FM146286 Methyl 2-amino-4,6-dichloropyridine-3-carboxylate 1044872-40-3 1g $900 2026-06-04 Buy
Biosynth FM146286 Methyl 2-amino-4,6-dichloropyridine-3-carboxylate 1044872-40-3 0.5g $900 2026-06-04 Buy
Biosynth FM146286 Methyl 2-amino-4,6-dichloropyridine-3-carboxylate 1044872-40-3 0.25g $900 2026-06-04 Buy
Product number Packaging Price Buy
FM146286 5g $900 Buy
FM146286 2g $900 Buy
FM146286 1g $900 Buy
FM146286 0.5g $900 Buy
FM146286 0.25g $900 Buy

2-Amino-4,6-dichloro-nicotinicacidmethylester Chemical Properties, Uses, Production

Uses

Methyl 2-Amino-4,6-dichloropyridine-3-carboxylate is used in preparation of macrocyclic broad spectrum antibiotics.

Synthesis

methyl 2-amino-4,6-dihydroxynicotinate

523992-26-9

2-Amino-4,6-dichloro-nicotinicacidmethylester

1044872-40-3

The general procedure for the synthesis of methyl 2-amino-4,6-dihydroxynicotinate from methyl 2-amino-4,6-dihydroxynicotinate is as follows: Step 116-2: Methyl 2-amino-4,6-dihydroxynicotinate (30 g), phosphorochloridic acid (150 ml) and N,N-diisopropylethylamine (30 ml) obtained in step 116-1 were mixed and the mixture was stirred at room temperature for 3 days. Upon completion of the reaction, the reaction mixture was concentrated, followed by azeotropic distillation with toluene 3 times to remove residual water. Methanol (30 ml) and water (150 ml) were slowly added to the residue under cooling in an ice bath and the mixture was continued to be stirred at room temperature for 1 hour. The resulting solid was collected by filtration and this solid was combined with the solid precipitated from the filtrate. Methanol (50 ml) was added to the combined solids and after stirring for 1 hour at room temperature, the solids were collected by filtration to give primary crystals. The filtrate was concentrated, methanol (10 ml) was added to the residue and the solid was again collected by filtration to obtain secondary crystals. Finally, the primary and secondary crystals were combined to afford the target compound methyl 2-amino-4,6-dichloronicotinate (21 g, 59% yield). 1H-NMR (DMSO-D6) δ: 3.84 (s, 3H), 6.84 (s, 1H), 7.16 (br s, 2H).

References

[1] Patent: US2011/77267, 2011, A1. Location in patent: Page/Page column 48
[2] Patent: US2008/188467, 2008, A1. Location in patent: Page/Page column 48
[3] Patent: WO2015/103355, 2015, A1. Location in patent: Paragraph 0213

2-Amino-4,6-dichloro-nicotinicacidmethylester Preparation Products And Raw materials

Raw materials

methyl 2-amino-4,6-dihydroxynicotinate Dimethyl 1,3-acetonedicarboxylate Cyanamide

Preparation Products

2-Amino-4,6-dichloro-nicotinicacidmethylester Suppliers

Global Suppliers ( 125)
Supplier Tel Email Country ProdList Advantage
Shandong Meiao Huawei Technology Co., LTD 0531-88682301 18595278766 yuhongmeng@mayowell.com China 88 58
Hangzhou Chemtrue Bio-Tech Co.,Ltd. 19967494293 sales@chemtrue-bio.com China 303 58
Beijing Huikang Boyuan Chemical Tech Co., Ltd 010-68862197 13810598707;13810598707 sales@huikangchem.com China 97 61
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 996 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
EnciPharmatech Co., Ltd 025-52714267-66 13813902930 stephen_shengll@hotmail.com China 231 64
China Langchem Inc. 0086-21-58956006 China 7798 57
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
Supplier Advantage
Shandong Meiao Huawei Technology Co., LTD 58
Hangzhou Chemtrue Bio-Tech Co.,Ltd. 58
Beijing Huikang Boyuan Chemical Tech Co., Ltd 61
Energy Chemical 61
Carbott PharmTech Inc. 56
Capot Chemical Co., Ltd 66
Shanghai Longsheng chemical Co.,Ltd. 59
EnciPharmatech Co., Ltd 64
China Langchem Inc. 57
Shanghai Topbiochem Technology Co., Ltd 58

View Latest Price from 2-Amino-4,6-dichloro-nicotinicacidmethylester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-4,6-dichloro-nicotinicacidmethylester pictures 2026-08-08 2-Amino-4,6-dichloro-nicotinicacidmethylester
1044872-40-3
 1kg 99.0% 20 tons Hangzhou ICH Biofarm Co., Ltd
2-amino-4,6-dichloro-nicotinic acid methyl ester pictures 2021-07-13 2-amino-4,6-dichloro-nicotinic acid methyl ester
1044872-40-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
2-amino-4,6-dichloro-nicotinic acid methyl ester pictures 2021-07-10 2-amino-4,6-dichloro-nicotinic acid methyl ester
1044872-40-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Amino-4,6-dichloro-nicotinicacidmethylester Spectrum

2-Amino-4,6-dichloro-nicotinicacidmethylester(1044872-40-3)1HNMR

1044872-40-3 (2-Amino-4,6-dichloro-nicotinicacidmethylester) Related Search:

3-Pyridinecarboxylic acid, 2-amino-4,6-dichloro- Methyl 2-amino-6-chloronicotinate Methyl 6-aMino-4-chloronicotinate 3-Pyridinecarboxaldehyde, 2-amino-4,6-dichloro- 2-amino-4,6-dichloropyridine-3-carboxylic acid hydrochloride
(2-Amino-4,6-dichloropyridin-3-yl)methanol

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2-Amino-4,6-dichloropyridine-3-carboxylic acid methyl ester Methyl 2-amino-4,6-dichloropyridine-3-carboxylate 3-Pyridinecarboxylicacid, 2-amino-4,6-dichloro-, methyl ester 2-amino-4,6-dichloro-, methyl ester 3-Pyri 2-Amino-4,6-dichloro-nicotinicacidmethylester 3-Pyridinecarboxylicacid, 2-amino-4,6-dichloro-, methyl este... 3-pyridinecarboxylic acid, 2-amino-4,6-dichloro-, methyl ester Methyl 2-aMino-4,6-dichloronicotinate 2-Amino-2,4-Dichloronicotinic acid methyl ester 1044872-40-3