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ChemicalBook >> CAS DataBase List >>2-Bromo-4,5-difluorobenzaldehyde

2-Bromo-4,5-difluorobenzaldehyde

2-Bromo-4,5-difluorobenzaldehyde Structure
2-Bromo-4,5-difluorobenzaldehyde structure
CAS No.
476620-54-9
Chemical Name:
2-Bromo-4,5-difluorobenzaldehyde
Synonyms
5-difluorobenzaldehyde;2-Bromo-4,5-difluorobenzaldehyde;Benzaldehyde, 2-bromo-4,5-difluoro-;2-Bromo-4,5-difluorobenzaldehyde,98%;2-Bromo-4,5-difluorobenzaldehyde ISO 9001：2015 REACH
CBNumber:
CB82490913
Molecular Formula:
C7H3BrF2O
Molecular Weight:
221
MDL Number:
MFCD16659662
MOL File:
476620-54-9.mol
MSDS File:
SDS
Last updated:2026-07-09 12:03:46
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2-Bromo-4,5-difluorobenzaldehyde Properties

Boiling point 232.0±35.0 °C(Predicted)
Density 1.758±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
form Powder
color Off-white
Water Solubility Slightly soluble in water.

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
HS Code  2913000090
NFPA 704
1
2 0

2-Bromo-4,5-difluorobenzaldehyde price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FB158617 2-Bromo-4,5-difluorobenzaldehyde 476620-54-9 5g $172.95 2026-06-04 Buy
Biosynth FB158617 2-Bromo-4,5-difluorobenzaldehyde 476620-54-9 10g $269 2026-06-04 Buy
Biosynth FB158617 2-Bromo-4,5-difluorobenzaldehyde 476620-54-9 25g $422.75 2026-06-04 Buy
Biosynth FB158617 2-Bromo-4,5-difluorobenzaldehyde 476620-54-9 50g $672.5 2026-06-04 Buy
Biosynth FB158617 2-Bromo-4,5-difluorobenzaldehyde 476620-54-9 100g $1076 2026-06-04 Buy
Product number Packaging Price Buy
FB158617 5g $172.95 Buy
FB158617 10g $269 Buy
FB158617 25g $422.75 Buy
FB158617 50g $672.5 Buy
FB158617 100g $1076 Buy

2-Bromo-4,5-difluorobenzaldehyde Chemical Properties, Uses, Production

Uses

It is an important intermediate for pharmaceutical and organic synthesis.

Synthesis

(2-Bromo-4,5-difluorophenyl)methanol

476620-55-0

2-Bromo-4,5-difluorobenzaldehyde

476620-54-9

General procedure for the synthesis of 2-bromo-4,5-difluorobenzaldehyde from (2-bromo-4,5-difluorophenyl)methanol: (2-bromo-4,5-difluorophenyl)methanol (1.23 g, 5.50 mmol), triethylamine (1.39 g, 13.75 mmol) and dimethylsulfoxide (1.72 g, 22.00 mmol) were dissolved in dichloromethane (25 mL) in dichloromethane (25 mL) and cooled to 0°C. Subsequently, sulfur trioxide-pyridine complex (1.32 g, 8.25 mmol) was added in batches. The reaction mixture was stirred at 0 °C for 1 h. Triethylamine (1.39 g, 13.75 mmol), dimethyl sulfoxide (1.72 g, 22.00 mmol) and sulfur trioxide-pyridine complex (1.32 g, 8.25 mmol) were added again. After continued stirring at 0 °C for 30 min, the reaction solution was diluted with dichloromethane (50 mL) and washed sequentially with saturated sodium bicarbonate solution and saturated sodium thiosulfate solution. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by fast column chromatography (RediSep fast column, 230-400 mesh silica gel, eluent 10-30% ethyl acetate in hexane solution) afforded 2-bromo-4,5-difluorobenzaldehyde (0.47 g, 39% yield).1H NMR (300 MHz, CDCl3) δ 10.23 (s, 1H), 7.77 (m, 1H), 7.52 (m, 1H).

References

[1] Patent: WO2010/55005, 2010, A1. Location in patent: Page/Page column 70-71
[2] Patent: WO2011/20193, 2011, A1. Location in patent: Page/Page column 18-19
[3] Patent: WO2011/57382, 2011, A1. Location in patent: Page/Page column 21
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1953 - 1957

2-Bromo-4,5-difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

(2-Bromo-4,5-difluorophenyl)methanol Triethylamine Dichloromethane Pyridine sulfur trioxide Dimethyl sulfoxide

Preparation Products

2-Bromo-4,5-difluorobenzaldehyde Suppliers

Global Suppliers ( 106)
Supplier Tel Email Country ProdList Advantage
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Beijing Eternalchem Co,. Ltd. 010-59484199 18611897322;18611897322; sales@eternalchem.com China 1993 60
Tianjin Jinyuda Chemical Co., Ltd. 022-58013646 13011382049 sales@jinyudachem.com China 1976 55
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Supplier Advantage
Alfa Aesar 84
Energy Chemical 61
Accela ChemBio Co.,Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Beijing Eternalchem Co,. Ltd. 60
Tianjin Jinyuda Chemical Co., Ltd. 55
Nanjing Norris-Pharm Technology Co., Ltd 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65

View Latest Price from 2-Bromo-4,5-difluorobenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-bromo-4,5-difluorobenzaldehyde pictures 2026-07-08 2-bromo-4,5-difluorobenzaldehyde
476620-54-9
 1KG 98% 20Tons Shaanxi Dideu New Materials Co. Ltd
2-Bromo-4,5-difluorobenzaldehyde pictures 2020-02-18 2-Bromo-4,5-difluorobenzaldehyde
476620-54-9
 $7.00 1KG 99% 100kg Career Henan Chemical Co

2-Bromo-4,5-difluorobenzaldehyde Spectrum

2-Bromo-4,5-difluorobenzaldehyde(476620-54-9)1HNMR

476620-54-9 (2-Bromo-4,5-difluorobenzaldehyde) Related Search:

2-Bromo-4,5-difluorobenzoic acid 2-Bromo-4,5-difluorobenzonitrile Ethyl 2-bromo-4,5-difluorobenzoate Methyl 2-bromo-4,5-difluorobenzoate (2-Bromo-4,5-difluorophenyl)methanol
2-Bromo-3,4-difluorobenzaldehyde

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2-Bromo-4,5-difluorobenzaldehyde Benzaldehyde, 2-bromo-4,5-difluoro- 2-Bromo-4,5-difluorobenzaldehyde,98% 2-Bromo-4,5-difluorobenzaldehyde ISO 9001：2015 REACH 5-difluorobenzaldehyde 476620-54-9