1,4-BENZODIOXAN-6-CARBOXALDEHYDE
- CAS No.
- 29668-44-8
- Chemical Name:
- 1,4-BENZODIOXAN-6-CARBOXALDEHYDE
- Synonyms
- AKOS BBS-00002725;TIMTEC-BB SBB003914;7-Formyl-1,4-benzodioxane;6-FORMYL-1,4-BENZODIOXANE;1,4-Benzodioxane-6-aldehyde;3,4-ETHYLENEDIOXYBENZALDEHYDE;Benzodioxalane-6-carbaldehyde;1,4-BENZODIOXAN-6-CARBALDEHYDE;1,4-Benzodioxane-6-carbaldehyde;1,4-BENZODIOXAN-6-CARBOXALDEHYDE
- CBNumber:
- CB8249771
- Molecular Formula:
- C9H8O3
- Molecular Weight:
- 164.16
- MDL Number:
- MFCD00010092
- MOL File:
- 29668-44-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1,4-Benzodioxan-6-carboxaldehyde 98% | 264598 | 5g | $36 |
| 3,4-Ethylenedioxybenzaldehyde >98.0%(GC) | B2019 | 1g | $17 |
| 3,4-Ethylenedioxybenzaldehyde >98.0%(GC) | B2019 | 5g | $55 |
| 2,3-Dihydro-1,4-benzodioxine-6-carbaldehyde 97% | 081722 | 5g | $21 |
| 1,4-Benzodioxan-6-carbaldehyde | J94781 | 5g | $22 |
| More product size | |||
| Melting point | 50-52 °C(lit.) |
|---|---|
| Boiling point | 105 °C15 mm Hg(lit.) |
| Density | 1.2132 (rough estimate) |
| refractive index | 1.5380 (estimate) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Solubility in methanol is almost transparent. |
| form | Chunks and Powder |
| color | Yellow-beige |
| InChI | InChI=1S/C9H8O3/c10-6-7-1-2-8-9(5-7)12-4-3-11-8/h1-2,5-6H,3-4H2 |
| InChIKey | CWKXDPPQCVWXAG-UHFFFAOYSA-N |
| SMILES | O1C2=CC=C(C=O)C=C2OCC1 |
| CAS DataBase Reference | 29668-44-8(CAS DataBase Reference) |
| FDA UNII | 92TK3MD2XP |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29329990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
1,4-BENZODIOXAN-6-CARBOXALDEHYDE price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 264598 | 1,4-Benzodioxan-6-carboxaldehyde 98% | 29668-44-8 | 5g | $36 | 2023-01-07 | Buy |
| TCI Chemical | B2019 | 3,4-Ethylenedioxybenzaldehyde >98.0%(GC) | 29668-44-8 | 1g | $17 | 2026-03-19 | Buy |
| TCI Chemical | B2019 | 3,4-Ethylenedioxybenzaldehyde >98.0%(GC) | 29668-44-8 | 5g | $55 | 2026-03-19 | Buy |
| Matrix Scientific | 081722 | 2,3-Dihydro-1,4-benzodioxine-6-carbaldehyde 97% | 29668-44-8 | 5g | $21 | 2021-12-16 | Buy |
| AK Scientific | J94781 | 1,4-Benzodioxan-6-carbaldehyde | 29668-44-8 | 5g | $22 | 2021-12-16 | Buy |
1,4-BENZODIOXAN-6-CARBOXALDEHYDE Chemical Properties,Uses,Production
Description
1,4-benodioxan-6-carboxaldehyde is a kind of aldehyde derivative. It is a useful intermediate in organic synthesis. It can be used as the building bock of the manufacturing tetrahydroisoquinoliones and benzofuran analog (a inhibitor of cAMP-specific phosphodiesterase type IV). It can also be used as an intermediate during the manufacturing of some novel Dopamine D3 and D4 receptor antagonists. It can also be used as the initial material for the manufacturing of some novel chalcone analogues that exhibit strong anti-tumor activity and low toxic side effects.
Chemical Properties
Yellowish-beige powder and chunks
Uses
1,4-Benzodioxane-6-carboxaldehyde was screened as a fragment for inhibitors of PDEA using enthalpy arrays and X-ray crystallography. 1,4-Benzodioxane-6-carboxaldehyde have also been used as an interme diate in the synthesis of a new class of Dopamine D3 and D4 receptor antagonists.
Uses
1,4-Benzodioxan-6-carboxaldehyde finds its uses as building block in the synthesis of tetrahydroisoquinolinones, in the preparation of benzofuran analog, a potential inhibitor of CAMP-specific phosphodiesterase type IV, in the synthesis of (5Z)-5-(2,3-dihydro-1,4-benzodioxan-6-ylmethylene)-1-methyl-2-thioxoimidazolidin-4-one. It was screened as a fragment for inhibitors of PDEA using enthalpy arrays and X-ray crystallography. 1,4-Benzodioxane-6-carboxaldehyde have also been used as an intermediate in the synthesis of a new class of Dopamine D3 and D4 receptor antagonists.
Definition
ChEBI: 2,3-dihydro-1,4-benzodioxine-6-carbaldehyde is a heteroarenecarbaldehyde in which a formyl group is located at position 6 of 2,3-dihydro-1,4-benzodioxine. It is a heteroarenecarbaldehyde and a benzodioxine.
Synthesis
106-93-4
139-85-5
29668-44-8
In this step, 3,4-dihydroxybenzaldehyde was used as the starting material to synthesize the intermediate 2,3-dihydro-1,4-benzodioxane-6-carbaldehyde by nucleophilic substitution reaction with 1,2-dibromoethane under alkaline conditions. The base used in this reaction was potassium hydroxide and the phase transfer catalyst was tetrabutylammonium bromide; the molar ratio of the reactants was 3,4-dihydroxybenzaldehyde:1,2-dibromoethane=1:5; the amount of sodium hydroxide was more than five times that of 3,4-dihydroxybenzaldehyde to ensure that the reaction was carried out under strong basic conditions. The reaction temperature was maintained at reflux temperature.
References
https://www.alfa.com/zh-cn/catalog/A18696/
Jiang, Ji Miao, et al. "Study on the synthesis and anti-tumor activity of novel chalcone analogues." Chemical Research & Application 22.11(2010): 1405-1408.
1,4-BENZODIOXAN-6-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 671 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29824 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
View Lastest Price from 1,4-BENZODIOXAN-6-CARBOXALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-10 | 1,4-BENZODIOXAN-6-CARBOXALDEHYDE
29668-44-8
|
US $0.00 / kg | 1kg | 98% | Customise | Hefei Lbao Physical & Chemical Science Co.,Ltd | |
 |
2025-04-04 | 1,4-BENZODIOXAN-6-CARBOXALDEHYDE
29668-44-8
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-06 | 1,4-BENZODIOXAN-6-CARBOXALDEHYDE
29668-44-8
|
US $1.00 / kg | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- 1,4-BENZODIOXAN-6-CARBOXALDEHYDE
29668-44-8
- US $0.00 / kg
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 1,4-BENZODIOXAN-6-CARBOXALDEHYDE
29668-44-8
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1,4-BENZODIOXAN-6-CARBOXALDEHYDE
29668-44-8
- US $1.00 / kg
- 95%-99%
- Career Henan Chemical Co
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