6-Bromothiochroman-4-one
- CAS No.
- 13735-13-2
- Chemical Name:
- 6-Bromothiochroman-4-one
- Synonyms
- 6-Bromothiochroman-4-one;6-BroMo-3,4-dihydro-2H-1-benzothiin-4-one;6-bromo-2,3-dihydro-4H-1-Benzothiopyran-4-one;4H-1-Benzothiopyran-4-one, 6-bromo-2,3-dihydro-
- CBNumber:
- CB82504827
- Molecular Formula:
- C9H7BrOS
- Molecular Weight:
- 243.12
- MDL Number:
- MFCD05664869
- MOL File:
- 13735-13-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 43 | |||||||||
| Safety Statements | 36/37 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
6-Bromothiochroman-4-one price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | B51315 | 6-Bromothiochroman-4-one 95+% | 13735-13-2 | 250mg | $28 | 2026-05-06 | Buy |
| Synthonix | B51315 | 6-Bromothiochroman-4-one 95+% | 13735-13-2 | 1g | $34 | 2026-05-06 | Buy |
| Synthonix | B51315 | 6-Bromothiochroman-4-one 95+% | 13735-13-2 | 5g | $130 | 2026-05-06 | Buy |
| Synthonix | B51315 | 6-Bromothiochroman-4-one 95+% | 13735-13-2 | 10g | $260 | 2026-05-06 | Buy |
| Synthonix | B51315 | 6-Bromothiochroman-4-one 95+% | 13735-13-2 | 25g | $660 | 2026-05-06 | Buy |
6-Bromothiochroman-4-one Chemical Properties, Uses, Production
Chemical Properties
Orange solid
Synthesis
3528-17-4
909248-27-7
13735-13-2
General procedure for the synthesis of 6-bromothiochroman-4-one and 6,8-dibromothiochroman-4-one from thiochroman-4-one: Anhydrous aluminum trichloride (1.81 g, 13.5 mmol) and methylene chloride (1 mL) were added to a round bottom flask at room temperature. After stirring for about 7 min under nitrogen protection, a solution of thiocolchroman-4-one (1.11 g, 6.77 mmol) in dichloromethane (1 mL) was slowly added. Stirring was continued for 10 minutes and then a solution of bromine (1.19 g, 7.44 mmol) in dichloromethane (2 mL) was added dropwise. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was poured into ice water (50 mL) and the aqueous phase was extracted with ethyl acetate three times. The organic phases were combined, washed once with saturated saline and dried over anhydrous sodium sulfate. The crude product was purified by fast column chromatography (15% ethyl acetate/85% hexane) to give a mixture of 6-bromothiochroman-4-one (0.648 g, 34% purity, 13% yield) and 6,8-dibromothiochroman-4-one (66% purity, 20% yield).The NMR data for 6,8-dibromothiochroman-4-one were as follows:1H NMR (300 MHz , CDCl3, δ): 8.18 (dd, J = 2.2, 0.7 Hz, Ar-H, 1H), 7.77 (dd, J = 2.2, 0.7 Hz, Ar-H, 1H), 3.22 (m, CH2, 2H), 2.94 (m, CH2, 2H). 13C NMR (75 MHz, CDCl3): δ 192.0, 142.5 , 139.1, 136.0, 131.0, 122.2, 118.2, 37.8, 26.0.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 16, p. 4405 - 4409
[2] Patent: US2009/76076, 2009, A1. Location in patent: Page/Page column 24
6-Bromothiochroman-4-one Preparation Products And Raw materials
6-Bromothiochroman-4-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
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| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| LABTER PHARMATECH(BEIJING) CO.,LTD | 010-56330744 18310155299 | sales@labter.com.cn | China | 19999 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
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| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Labnetwork lnc. | +86-27-50766799 +86-18062016861 | contact@labnetwork.com | China | 19981 | 58 |
