8-hydrazinylquinoline hydrochloride
- CAS No.
- 14148-42-6
- Chemical Name:
- 8-hydrazinylquinoline hydrochloride
- Synonyms
- Quinoline, 8-hydrazinyl-;8-hydrazinylquinoline hydrochloride
- CBNumber:
- CB82506083
- Molecular Formula:
- C9H9N3
- Molecular Weight:
- 159.19
- MDL Number:
- MFCD00462947
- MOL File:
- 14148-42-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
8-hydrazinylquinoline hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS210538 | 8-Hydrazinoquinoline 95% | 14148-42-6 | 1g | $294 | 2026-06-04 | Buy |
| Activate Scientific | AS210538 | 8-Hydrazinoquinoline 95% | 14148-42-6 | 5g | $830 | 2026-06-04 | Buy |
| aablocks | AA001GDI | 8-Hydrazinylquinoline 95% | 14148-42-6 | 250mg | $90 | 2026-05-28 | Buy |
| aablocks | AA001GDI | 8-Hydrazinylquinoline 95% | 14148-42-6 | 1g | $207 | 2026-05-28 | Buy |
| aablocks | AA001GDI | 8-Hydrazinylquinoline 95% | 14148-42-6 | 5g | $585 | 2026-05-28 | Buy |
8-hydrazinylquinoline hydrochloride Chemical Properties, Uses, Production
Preparation
the original preparation of 8-Hydrazinoquinoline (8-HQ) involved the diazotization of commercially
available 8-aminoquinoline followed by reduction with tin(II) chloride.[1] An improved one-step method has
been developed which starts with the less expensive 8-hydroxyquinoline.[2] Sulfur dioxide (10 g) is
dissolved in hydrazine hydrate (80 mL), 8-hydroxyquinoline (10.16 g) is added and the mixture is refluxed
for 7 d. Every 48 h, EtOH (10 mL) is added to dissolve any starting material which may have sublimed into
the condenser. The mixture is cooled, 2 M NaOH (100 mL) is added, and the resulting emulsion is
extracted with CHCl3 (4 × 75 mL). The combined organic layers are washed with brine (20 mL), dried over
MgSO4, and concentrated. The residue crystallizes upon standing and may be recrystallized from CH2Cl2
and pentane to afford 8.7 g (78%) of 8-HQ as pale yellow needles (eq 1).
storage
8-hydrazinylquinoline hydrochloride is sensitive to air and light and is best kept under an inert atmosphere at 0 °C in the dark. Slow decomposition occurs with time and the material turns brown. In the early stages it can be repurified by recrystallization. Use in a fume hood.
References
1. Hünig, S.; Werner, H. LA 1959, 628, 46.
2. Hegde, V.; Hung, C.-Y.; Madhukar, P.; Cunningham, R.; Hpfner, T.; Thummel, R. P. JACS 1993, 115, 872.
8-hydrazinylquinoline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
8-hydrazinylquinoline hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai zhigan biotechnology co., LTD | zhiqianbio@126.com | China | 19765 | 58 | |
| Ningbo jinuo chemical co., LTD | 0574-87314919 057487319282 | info@nbinno.com | China | 7046 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Shanghai Jieshikai Biotechnology Co. , Ltd. | 021-57520305 13795461237 | zhuruyan@jskchem.com | China | 49221 | 58 |
| Nanjing Thander New Material Science & Technology Co., Ltd | 15384069853 | 2048571647@qq.com | China | 472 | 58 |
| https://www.shachemlin.cn/ | 68080707 15021879576 | ming-jiao.wu@chemlin.com.cn | China | 9312 | 58 |
| Yantai Shengkailun Chemical Technology Co., Ltd. | 13356901049 | mark@sklnchem.cn | China | 9925 | 58 |
| Hefei Mokai Pharmaceutical Technology Co., Ltd | 18130062233 | 690231469@qq.com | China | 7999 | 58 |
| Wuhan Henruixintai Biological Co., Ltd. | 027-027-65522215 18163303831 | 360034463@qq.com | China | 1612 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 81148925 17391631969 | 1023@dideu.com | China | 9998 | 58 |
