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ChemicalBook >> CAS DataBase List >>8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone Structure
8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone structure
CAS No.
530084-79-8
Chemical Name:
8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone
Synonyms
quinolin-2(1H);EOS-62123;8-(Benzylox;-8-(Benzyloxy);-5-(2-bromo-1-hydroxyethyl);(R)-8-Benzyloxy-5-(2-broMo-1-hydroxyethyl)carbostyril;8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone;8-Benzyloxy-5((R)-2-broMo-1-hydroxyethyl)-2-(1H)-quinoline;8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolin-2-one;5-(2-BroMo-(R)-1-hydroxyethyl)-8-benzyloxy-2(1H)-quinolinone
CBNumber:
CB82543529
Molecular Formula:
C18H16BrNO3
Molecular Weight:
374.23
MDL Number:
MFCD20484048
MOL File:
530084-79-8.mol
MSDS File:
SDS
Last updated:2026-05-28 05:07:23
Product description Number Pack Size Price
8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone TRC-B286110-25MG 25mg $1503
8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone TRC-B286110-2.5MG 2.5mg $193
8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone 003688 2.5mg $446
8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone FB18469 2g $900
8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone FB18469 1g $900
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8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone Properties

Melting point >153oC (dec.)
Boiling point 595.8±50.0 °C(Predicted)
Density 1.490±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Ethyl Acetate (Slightly)
form Solid
pka 10.78±0.70(Predicted)
color Light Beige
InChI InChI=1S/C18H16BrNO3/c19-10-15(21)13-6-8-16(18-14(13)7-9-17(22)20-18)23-11-12-4-2-1-3-5-12/h1-9,15,21H,10-11H2,(H,20,22)/t15-/m0/s1
InChIKey GNFMSZCSSUZAGV-HNNXBMFYSA-N
SMILES N1C2=C(C([C@@H](O)CBr)=CC=C2OCC2=CC=CC=C2)C=CC1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338-P310

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-B286110-25MG 8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone 530084-79-8 25mg $1503 2026-06-03 Buy
TRC TRC-B286110-2.5MG 8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone 530084-79-8 2.5mg $193 2026-06-03 Buy
Usbiological 003688 8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone 530084-79-8 2.5mg $446 2026-06-03 Buy
Biosynth FB18469 8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone 530084-79-8 2g $900 2026-06-04 Buy
Biosynth FB18469 8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone 530084-79-8 1g $900 2026-06-04 Buy
Product number Packaging Price Buy
TRC-B286110-25MG 25mg $1503 Buy
TRC-B286110-2.5MG 2.5mg $193 Buy
003688 2.5mg $446 Buy
FB18469 2g $900 Buy
FB18469 1g $900 Buy

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone Chemical Properties,Uses,Production

Chemical Properties

Light Brown Solid

Uses

8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone is used in the preparation of phenylethanolamine derivatives as β2 adrenoreceptor agonists.

Synthesis

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline

100331-89-3

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone

530084-79-8

General procedure for the synthesis of 8-benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolin-2-one from 1-(8-(benzyloxy)-2-hydroxyquinolin-5-yl)-2-bromoacetophenone: Under nitrogen protection, the tetrahydrofuran (1400 mL) and 1-(8-(benzyloxy)-2-hydroxyquinolin-5-yl)-2-bromoacetophenone (100 g) were The mixture was cooled to 0-5°C. Subsequently, R-methyl CBS (7.5 g) was slowly added and boron dimethyl sulfide complex (24.3 g) was added at 0-10°C. The reaction was carried out at 0-10°C. The reaction was carried out at 0-10°C. The reaction mixture was stirred at 0-10°C for 1-2 h. The reaction progress was monitored by HPLC. Upon completion of the reaction, methanol (100 mL) was slowly added and stirring was continued at 0-10°C for 15 min. Subsequently, the reaction mixture was distilled under vacuum at 40-45°C and then cooled to 25-30°C. The cooled reaction mixture was slowly added to hydrochloric acid solution and stirred for 1-2 h at 25-30°C. The reaction mixture was then purified by HPLC. The resulting solid was filtered, washed with water (300 mL) and dried at 65-70°C for 8 hours. The product yield was 95%.

References

[1] Patent: US2016/326118, 2016, A1. Location in patent: Paragraph 0067; 0068
[2] Patent: US2004/224982, 2004, A1. Location in patent: Page 3; 10
[3] Patent: US2004/242622, 2004, A1. Location in patent: Page 30
[4] Patent: US2004/167167, 2004, A1. Location in patent: Page/Page column 34
[5] Patent: US2006/35933, 2006, A1. Location in patent: Page/Page column 25

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone Preparation Products And Raw materials

Raw materials

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Borane-methyl sulfide complex Hydrochloric acid Tetrahydrofuran

Preparation Products

12401 (8-(benzyloxy)-5-[(1R)-2-broMo-1-{[tert-butyl(diMethyl)silyl]oxy}ethyl]quinolin-2(1H)-one )

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone Suppliers

Global( 162)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1319 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569266 +86-17392581500 1015@dideu.com China 3991 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Antai Fine Chemical Technology Co.,Limited 		58

View Lastest Price from 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone pictures 2025-04-04 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone
530084-79-8
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one pictures 2021-07-13 (R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one
530084-79-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one pictures 2021-07-10 (R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one
530084-79-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

530084-79-8(8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone)Related Search:

1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aR,7aR)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine BENZYLOXYACETALDEHYDE Indacaterol Impurity 7 Procaterolhydrochloridehemidrate
Indacaterol Impurity 22 Indacaterol Impurity 13 (Mixture of Diastereomers) Indacaterol interMediate 2(1H)-Quinolinone, 5-[(1S)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)- 2(1H)-Quinolinone, 5,5'-[[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)imino]bis(1-hydroxy-2,1-ethanediyl)]bis[8-(phenylmethoxy)-
Indacaterol Impurity 12 8-HYDROXY-QUINOLINE-5-CARBALDEHYDE Indacaterol Impurity 34 5-Acetyl-8-(phenylmethoxy)-2-quinolinone 2-Aminoindan hydrochloride
5-ACETYL-8-HYDROXY-1H-QUINOLIN-2-ONE 2(1H)-Quinolinone, 8-hydroxy-5-[(1R,2R)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, rel- 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone

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8-benzyloxy-5((R)-2-broMo-1-hydroxyethyl)-2-(1H-)-quinolinone (R)-8-Benzyloxy-5-(2-broMo-1-hydroxyethyl)carbostyril 5-(2-BroMo-(R)-1-hydroxyethyl)-8-benzyloxy-2(1H)-quinolinone 5-[(1R)-2-BroMo-1-hydroxyethyl]-8-(phenylMethoxy)-2(1H)-quinolinone 8-(Benzylox (R)-8-(Benzyloxy)-5-(2-broMo-1-hydroxyethyl)quinolin-2(1H)-one 8-Benzyloxy-5((R)-2-broMo-1-hydroxyethyl)-2-(1H)-quinoline 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolin-2-one 8-(Benzyloxy)-5-((1R)-2-bromo-1-hydroxyethyl)quinolin-2(1H)-one 8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]-1,2-dihydroquinolin-2-one -5-(2-bromo-1-hydroxyethyl) -8-(Benzyloxy) quinolin-2(1H) 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone EOS-62123 2(1H)-Quinolinone, 5-[(1R)-2-bromo-1-hydroxyethyl]-8-(phenylmethoxy)- 8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-... 8-benzyloxy-5- ((R) -2-bromo-1-hydroxyethyl) -1H-quinoline-2-one 8-Benzyloxyl-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolin-2-one (R)-8-(Benzyloxyl)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one (R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one (Indacaterol Impurity) 530084-79-8 Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals