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8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone structure

CAS No.: 530084-79-8

Chemical Name:: 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone

Synonyms: quinolin-2(1H);EOS-62123;8-(Benzylox;-8-(Benzyloxy);-5-(2-bromo-1-hydroxyethyl);(R)-8-Benzyloxy-5-(2-broMo-1-hydroxyethyl)carbostyril;8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone;8-Benzyloxy-5((R)-2-broMo-1-hydroxyethyl)-2-(1H)-quinoline;8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolin-2-one;5-(2-BroMo-(R)-1-hydroxyethyl)-8-benzyloxy-2(1H)-quinolinone

CBNumber:: CB82543529

Molecular Formula:: C18H16BrNO3

Molecular Weight:: 374.23

MDL Number:: MFCD20484048

MOL File:: 530084-79-8.mol

Last updated:2025-07-24 18:13:47

Product description	Number	Pack Size	Price
8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone	B286110	2.5mg	$140
8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone	FB18469	2mg	$254.4
(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one	7504AB	100mg	$91
8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone	FB18469	1mg	$139.9
8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone	FB18469	5mg	$462.5
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8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone Properties

Melting point	>153oC (dec.)
Boiling point	595.8±50.0 °C(Predicted)
Density	1.490±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Ethyl Acetate (Slightly)
form	Solid
pka	10.78±0.70(Predicted)
color	Light Beige
InChI	InChI=1S/C18H16BrNO3/c19-10-15(21)13-6-8-16(18-14(13)7-9-17(22)20-18)23-11-12-4-2-1-3-5-12/h1-9,15,21H,10-11H2,(H,20,22)/t15-/m0/s1
InChIKey	GNFMSZCSSUZAGV-HNNXBMFYSA-N
SMILES	N1C2=C(C([C@@H](O)CBr)=CC=C2OCC2=CC=CC=C2)C=CC1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05
Signal word	Danger
Hazard statements	H318
Precautionary statements	P280-P305+P351+P338-P310

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B286110	8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone	530084-79-8	2.5mg	$140	2021-12-16	Buy
Biosynth Carbosynth	FB18469	8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone	530084-79-8	2mg	$254.4	2021-12-16	Buy
AK Scientific	7504AB	(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one	530084-79-8	100mg	$91	2021-12-16	Buy
Biosynth Carbosynth	FB18469	8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone	530084-79-8	1mg	$139.9	2021-12-16	Buy
Biosynth Carbosynth	FB18469	8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone	530084-79-8	5mg	$462.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
B286110	2.5mg	$140	Buy
FB18469	2mg	$254.4	Buy
7504AB	100mg	$91	Buy
FB18469	1mg	$139.9	Buy
FB18469	5mg	$462.5	Buy

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone Chemical Properties,Uses,Production

Chemical Properties

Light Brown Solid

Uses

8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone is used in the preparation of phenylethanolamine derivatives as β2 adrenoreceptor agonists.

Synthesis

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline

100331-89-3

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone

530084-79-8

General procedure for the synthesis of 8-benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolin-2-one from 1-(8-(benzyloxy)-2-hydroxyquinolin-5-yl)-2-bromoacetophenone: Under nitrogen protection, the tetrahydrofuran (1400 mL) and 1-(8-(benzyloxy)-2-hydroxyquinolin-5-yl)-2-bromoacetophenone (100 g) were The mixture was cooled to 0-5°C. Subsequently, R-methyl CBS (7.5 g) was slowly added and boron dimethyl sulfide complex (24.3 g) was added at 0-10°C. The reaction was carried out at 0-10°C. The reaction was carried out at 0-10°C. The reaction mixture was stirred at 0-10°C for 1-2 h. The reaction progress was monitored by HPLC. Upon completion of the reaction, methanol (100 mL) was slowly added and stirring was continued at 0-10°C for 15 min. Subsequently, the reaction mixture was distilled under vacuum at 40-45°C and then cooled to 25-30°C. The cooled reaction mixture was slowly added to hydrochloric acid solution and stirred for 1-2 h at 25-30°C. The reaction mixture was then purified by HPLC. The resulting solid was filtered, washed with water (300 mL) and dried at 65-70°C for 8 hours. The product yield was 95%.

References

[1] Patent: US2016/326118, 2016, A1. Location in patent: Paragraph 0067; 0068
[2] Patent: US2004/224982, 2004, A1. Location in patent: Page 3; 10
[3] Patent: US2004/242622, 2004, A1. Location in patent: Page 30
[4] Patent: US2004/167167, 2004, A1. Location in patent: Page/Page column 34
[5] Patent: US2006/35933, 2006, A1. Location in patent: Page/Page column 25

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone Preparation Products And Raw materials

Raw materials

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Borane-methyl sulfide complex Hydrochloric acid Tetrahydrofuran

Preparation Products

12401 (8-(benzyloxy)-5-[(1R)-2-broMo-1-{[tert-butyl(diMethyl)silyl]oxy}ethyl]quinolin-2(1H)-one )

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone Suppliers

Global( 160)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3965	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Shanghai Yingrui Biopharma Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone 530084-79-8	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-07-13	(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one 530084-79-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one 530084-79-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone
530084-79-8
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one
530084-79-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one
530084-79-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

530084-79-8(8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone)Related Search:

1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aR,7aR)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine BENZYLOXYACETALDEHYDE Indacaterol Impurity 7 Procaterolhydrochloridehemidrate

Indacaterol Impurity 22 Indacaterol Impurity 13 (Mixture of Diastereomers) Indacaterol interMediate 2(1H)-Quinolinone, 5-[(1S)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)- 2(1H)-Quinolinone, 5,5'-[[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)imino]bis(1-hydroxy-2,1-ethanediyl)]bis[8-(phenylmethoxy)-

Indacaterol Impurity 12 8-HYDROXY-QUINOLINE-5-CARBALDEHYDE Indacaterol Impurity 34 5-Acetyl-8-(phenylmethoxy)-2-quinolinone 2-Aminoindan hydrochloride

5-ACETYL-8-HYDROXY-1H-QUINOLIN-2-ONE 2(1H)-Quinolinone, 8-hydroxy-5-[(1R,2R)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, rel- 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone

1of4

8-benzyloxy-5((R)-2-broMo-1-hydroxyethyl)-2-(1H-)-quinolinone (R)-8-Benzyloxy-5-(2-broMo-1-hydroxyethyl)carbostyril 5-(2-BroMo-(R)-1-hydroxyethyl)-8-benzyloxy-2(1H)-quinolinone 5-[(1R)-2-BroMo-1-hydroxyethyl]-8-(phenylMethoxy)-2(1H)-quinolinone 8-(Benzylox (R)-8-(Benzyloxy)-5-(2-broMo-1-hydroxyethyl)quinolin-2(1H)-one 8-Benzyloxy-5((R)-2-broMo-1-hydroxyethyl)-2-(1H)-quinoline 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolin-2-one 8-(Benzyloxy)-5-((1R)-2-bromo-1-hydroxyethyl)quinolin-2(1H)-one 8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]-1,2-dihydroquinolin-2-one -5-(2-bromo-1-hydroxyethyl) -8-(Benzyloxy) quinolin-2(1H) 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone EOS-62123 2(1H)-Quinolinone, 5-[(1R)-2-bromo-1-hydroxyethyl]-8-(phenylmethoxy)- 8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-... 8-benzyloxy-5- ((R) -2-bromo-1-hydroxyethyl) -1H-quinoline-2-one 8-Benzyloxyl-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolin-2-one (R)-8-(Benzyloxyl)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one 530084-79-8 Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals