Ethyl 2-amino-1,3-thiazole-4-carboxylate
- CAS No.
- 5398-36-7
- Chemical Name:
- Ethyl 2-amino-1,3-thiazole-4-carboxylate
- Synonyms
- ETHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE;2-AMINO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;2-aminothiazole-4-carboxylate;ETHYL-2-AMINO-1,3-THIOZOLE-4-CARBOXYLATE;AKOS BB-9218;TOSLAB 14869;BUTTPARK 33\04-57;TIMTEC-BB SBB000178;Ethyl 2-amino-1,3-th;AclatoniumIntermediate
- CBNumber:
- CB8254719
- Molecular Formula:
- C6H8N2O2S
- Molecular Weight:
- 172.2
- MDL Number:
- MFCD00619079
- MOL File:
- 5398-36-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ethyl 2-aminothiazole-4-carboxylate 96% | 705152 | 1g | $43.2 |
| Ethyl 2-aminothiazole-4-carboxylate 96% | 705152 | 5g | $91.4 |
| Ethyl 2-Aminothiazole-4-carboxylate >98.0%(GC)(T) | E1215 | 5g | $35 |
| Ethyl 2-Aminothiazole-4-carboxylate >98.0%(GC)(T) | E1215 | 25g | $104 |
| Ethyl 2-amino-thiazole-4-carboxylate Asreported | 275622 | 10g | $425 |
| More product size | |||
| Melting point | 177 °C |
|---|---|
| Boiling point | 308.0±15.0 °C(Predicted) |
| Density | 1.336±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 2.60±0.10(Predicted) |
| color | Pale Beige |
| λmax | 284nm(MeOH)(lit.) |
| InChI | InChI=1S/C6H8N2O2S/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3,(H2,7,8) |
| InChIKey | XHFUVBWCMLLKOZ-UHFFFAOYSA-N |
| SMILES | S1C=C(C(OCC)=O)N=C1N |
| CAS DataBase Reference | 5398-36-7(CAS DataBase Reference) |
| FDA UNII | P5Q9ELY6B7 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280g-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 24/25-36/37/39-26-22 | |||||||||
| WGK Germany | nwg | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Ethyl 2-amino-1,3-thiazole-4-carboxylate price More Price(102)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 705152 | Ethyl 2-aminothiazole-4-carboxylate 96% | 5398-36-7 | 1g | $43.2 | 2023-06-20 | Buy |
| Sigma-Aldrich | 705152 | Ethyl 2-aminothiazole-4-carboxylate 96% | 5398-36-7 | 5g | $91.4 | 2023-06-20 | Buy |
| TCI Chemical | E1215 | Ethyl 2-Aminothiazole-4-carboxylate >98.0%(GC)(T) | 5398-36-7 | 5g | $35 | 2026-04-30 | Buy |
| TCI Chemical | E1215 | Ethyl 2-Aminothiazole-4-carboxylate >98.0%(GC)(T) | 5398-36-7 | 25g | $104 | 2026-04-30 | Buy |
| Usbiological | 275622 | Ethyl 2-amino-thiazole-4-carboxylate Asreported | 5398-36-7 | 10g | $425 | 2026-06-03 | Buy |
Ethyl 2-amino-1,3-thiazole-4-carboxylate Chemical Properties,Uses,Production
Chemical Properties
white crystal powde
Uses
Ethyl 2-Amino-1,3-thiazole-4-carboxylate is a chemical reagent used in the preparation fo SAR thiazolamino arylaminopyrimidines as anaplastic lymphoma kinase inhibitors. As well as in the synthesis of 4-bicyclick piperadine derivatives as potent stearoyl-CoA desaturase (SCD1) inhibitors in the treatment of cancer.
Synthesis
70-23-5
17356-08-0
5398-36-7
GENERAL METHOD: A mixture of thiourea (1.2 mmol) and ethyl 3-bromopyruvate (1 mmol) in ethanol (2 mL) was reacted with stirring at 70°C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and subsequently poured into ice water. The precipitate precipitated was collected by filtration and dried to give the target product ethyl 2-aminothiazole-4-carboxylate. The products were characterized as follows: 6a (99% yield), white solid, melting point 150-152 °C (literature value 149-150 °C); 6b (100% yield), white solid, melting point 162-165 °C (literature value 163-164 °C); 6c (0.236 g, 93% yield), white solid, melting point 179-181 °C (literature value 180- 181°C); 6d (98% yield), white solid, melting point 203.6-204.2°C (literature value 204.0-204.5°C); 6e (94% yield), bright yellow solid, melting point 287-288°C (literature value 285-286°C); 6f (100% yield), white solid, melting point 172-174°C (literature value 172°C).
References
[1] Arkivoc, 2018, vol. 2018, # 7, p. 110 - 118
[2] Patent: CN104016944, 2016, B. Location in patent: Paragraph 0014-0015; 0040-0041
[3] Organic and Biomolecular Chemistry, 2012, vol. 10, # 30, p. 5764 - 5768
[4] Letters in Drug Design and Discovery, 2018, vol. 16, # 2, p. 160 - 173
[5] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 151-152
Ethyl 2-amino-1,3-thiazole-4-carboxylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
View Lastest Price from Ethyl 2-amino-1,3-thiazole-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | Ethyl 2-amino-1,3-thiazole-4-carboxylate
5398-36-7
|
$6.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-05-07 | ethyl 2-aminothiazole-4-carboxylate
5398-36-7
|
1kg | 0.99 | 5 tons | Suzhou Nordica Biopharma CO.,LTD | ||
 |
2025-04-04 | Ethyl 2-amino-1,3-thiazole-4-carboxylate
5398-36-7
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Ethyl 2-amino-1,3-thiazole-4-carboxylate
5398-36-7
- $6.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- ethyl 2-aminothiazole-4-carboxylate
5398-36-7
- 0.99
- Suzhou Nordica Biopharma CO.,LTD
-
- Ethyl 2-amino-1,3-thiazole-4-carboxylate
5398-36-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
