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Olmesartan Medoxomil

Olmesartan Medoxomil Structure
Olmesartan Medoxomil structure
CAS No.
144689-63-4
Chemical Name:
Olmesartan Medoxomil
Synonyms
Benicar;OLMESARTAN MEDOXIMIL;Oimesartan;Olmesartan API;Olmesartan Medoxomi;OMST;CS-866;Olmetec;Omesartan ester;Olmesartn Medoxomil
CBNumber:
CB8254825
Molecular Formula:
C29H30N6O6
Molecular Weight:
558.59
MDL Number:
MFCD00944911
MOL File:
144689-63-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Product description Number Pack Size Price
Olmesartan medoxomil for system suitability European Pharmacopoeia (EP) Reference Standard Y0001424 10 mg $167
Olmesartan medoxomil European Pharmacopoeia (EP) Reference Standard Y0001405 100 mg $241
Olmesartan medoxomil Pharmaceutical Secondary Standard; Certified Reference Material PHR1851 200mg $299
Olmesartan medoxomil British Pharmacopoeia (BP) Reference Standard BP1173 100 mg $258
Olmesartan medoxomil United States Pharmacopeia (USP) Reference Standard 1478367 100mg $848
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Olmesartan Medoxomil Properties

Melting point 180°C
Boiling point 804.2±75.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
Flash point 180°C
storage temp. 2-8°C
solubility DMSO: soluble20mg/mL, clear
pka 4.15±0.10(Predicted)
form powder
color white to beige
Decomposition 180 ºC
InChIKey UQGKUQLKSCSZGY-UHFFFAOYSA-N
SMILES C1(CCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C(C(OCC2=C(C)OC(=O)O2)=O)=C(C(O)(C)C)N=1
CAS DataBase Reference 144689-63-4(CAS DataBase Reference)
FDA UNII 6M97XTV3HD
ATC code C09CA08
UNSPSC Code 41116107
NACRES NA.77

Pharmacokinetic data

Protein binding 99.7%
Excreted unchanged in urine 35-50%
Volume of distribution 0.24(L/kg)
Biological half-life 10-15 / 36

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Precautionary statements  P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
WGK Germany  WGK 3
RTECS  NI4014200
HS Code  2934990002
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
NFPA 704
0
3 0

Olmesartan Medoxomil price More Price(93)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001424 Olmesartan medoxomil for system suitability European Pharmacopoeia (EP) Reference Standard 144689-63-4 10 mg $167 2026-04-30 Buy
Sigma-Aldrich Y0001405 Olmesartan medoxomil European Pharmacopoeia (EP) Reference Standard 144689-63-4 100 mg $241 2026-04-30 Buy
Sigma-Aldrich PHR1851 Olmesartan medoxomil Pharmaceutical Secondary Standard; Certified Reference Material 144689-63-4 200mg $299 2026-04-30 Buy
Sigma-Aldrich BP1173 Olmesartan medoxomil British Pharmacopoeia (BP) Reference Standard 144689-63-4 100 mg $258 2026-04-30 Buy
Sigma-Aldrich 1478367 Olmesartan medoxomil United States Pharmacopeia (USP) Reference Standard 144689-63-4 100mg $848 2026-04-30 Buy
Product number Packaging Price Buy
Y0001424 10 mg $167 Buy
Y0001405 100 mg $241 Buy
PHR1851 200mg $299 Buy
BP1173 100 mg $258 Buy
1478367 100mg $848 Buy

Olmesartan Medoxomil Chemical Properties,Uses,Production

Description

Olmesartan medoxomil was launched in the US as benicar(R), an orally administered treatment for hypertension. Olmesartan, is a new selective and competitive nonpeptide angiotensin II type 1 receptor antagonist and potently inhibits the Ang.ll-induced pressor responses. The drug competitively inhibited binding of [125I1]-All to AT1 receptors in bovine adrenal cortical membranes, but had no effect on binding to AT2 receptors in bovine cerebellar membranes. In comparative clinical studies in patients with essential hypertension, olmesartan reduced sitting cuff diastolic blood pressure significantly more than losartan, valdesartan and ibesartan, while reductions in systolic blood pressure were similar for all treatments. Olmesartan medoxomil was also shown to reduce blood pressure significantly more effectively than losartan and the ACE inhibitor captopril and as effectively as the pbloker atenolol.

Chemical Properties

White to off-white crystalline powder

Originator

Sanky (Japan)

Uses

Olmesartan medoxomil is an angiotensin II receptor antagonist used to treat high blood pressure. Olmesartan works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle. By blocking the binding rather than the synthesis of angiotensin II, olmesartan inhibits the negative regulatory feedback on renin secretion.
Olmesartan medoxomil is a pro-drug that is de-esterified to the active metabolite, olmesartan. Olmesartan has a dual method of elimination, with about 60% eliminated by the liver and the remainder by the kidney. In situations of impaired renal or hepatic function, the alternative excretion pathway can compensate for the compromised one. Olmesartan is not metabolized by the cytochrome P450 enzyme system and therefore has a low potential for metabolic drug interactions, a feature that may be of importance when treating patients on multiple drug regimens, such as the elderly. Olmesartan is well tolerated and has an excellent safety profile that is comparable to that of placebo. In addition, olmesartan provides 24-h blood pressure control with a once-daily dosing. In head-to-head studies, olmesartan delivered superior blood pressure reduction when compared with other angiotensin-II receptor antagonists at their recommended doses.

Definition

ChEBI: Olmesartan medoxomil is a member of biphenyls.

brand name

Benicar

General Description

Olmesartan Medoxomil is a synthetic imidazole derivative prodrug with an antihypertensive property. Upon hydrolysis, olmesartan medoxomil is converted to olmesartan. Olmesartan selectively binds to the angiotensin type 1 (AT1) receptor of angiotensin II in vascular smooth muscle and adrenal gland, thereby competing angiotensin II binding to the receptor. This prevents angiotensin II-induced vasoconstriction and decreases aldosterone production, thereby preventing aldosterone-stimulated sodium retention and potassium excretion.

Biochem/physiol Actions

Olmesartan medoxomil is a selective Angiotensin II Type I receptor blocker and antihypertensive drug. Olmesartan medoxomil is converted enzymatically to the active form olmesartan.

Clinical Use

Angiotensin-II receptor antagonist:
Hypertension

Side effects

Dizziness or lightheadedness may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Synthesis

Olmesartan Medoxomil can be synthesized in 8 steps from diaminomaleonitrile by successive reactions with trialkylorthopropanoate to access 2-propyl-imidazole-45dicarbonitrile, conversion of the two nitrile functions to the corresponding ethyl esters, followed by methylmagnesium bromide addition to give the corresponding 4-(1-hydroxyalkyl)imidazole derivative.
synthesis of Olmesartan Medoxomil
The imidazole ring of olmesartan (18) was constructed with diaminomaleonitrile 155 and trimethylorthobutyrate (156) in CH3CN then xylene to give 157 in 96% yield. Acid hydrolysis of 157 in 6N HCl gave the dicarboxylic acid intermediate. After esterification of the diacid in ethanol in the presence of HCl, diester 158 was treated with MeMgCl to give 4-(1-hydroxyalkyl) imidazole 159 in 95% yield. Alkylation of 159 with biphenyl bromide 160 in the presence of potassium tbutoxide afforded 161 in 80% yield. Ester 161 was then hydrolyzed to free carboxylic acid 162 under basic conditions, and 162 was treated with chloride 163 in the presence of K2CO3 to give ester 164 in 88% yield from 161.Lastly, the trityl group was removed with 25% aqueous acetic acid to give olmesartan (18) in 81% yield.

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia hypotension and renal impairment with ACE-Is and aliskiren.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Lithium: reduced excretion (possibility of enhanced lithium toxicity).
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Olmesartan medoxomil is an ester prodrug that is hydrolysed during absorption from the gastrointestinal tract to the active form olmesartan. It is excreted in the urine and the bile as olmesartan; about 35-50% of the absorbed dose is excreted in the urine and the remainder in the bile.

Olmesartan Medoxomil synthesis

144690-92-6
144689-63-4
Synthesis of Olmesartan Medoxomil from Trityl olmesartan

Olmesartan Medoxomil Preparation Products And Raw materials

Raw materials

Trityl olmesartan Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole N-Trityl Olmesartan Ethyl Ester Trityl Olmesartan Medoxomil
1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester 4-Cloromethyl-5-methyl-1,3-dioxol-2-one

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Preparation Products

Olmesartan Medoxomil Suppliers

Global( 834)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.
admin@hsnordpharma.com China 92 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8737 58
Shandong Huisheng Import & Export Co., Ltd. 		+86-13176845580 da@zhongda-biotech.com China 216 58
Anhui Zhongda Biotechnology Co., Ltd 		+86-19956560829 justine@zhongda-biotech.com China 272 58
Anhui Zhongda Biotechnology Co., Ltd 		+86-15689548120 linda@zhongda-biotech.com China 184 58
Anhui Ruihan Technology Co., Ltd 		+undefined17756083858 daisy@anhuiruihan.com China 954 58
Hangzhou Hyper Chemicals Limited 		+86-0086-57187702781 +86-13675893055 info@hyper-chem.com China 309 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +86-15383190639 admin@86-ss.com China 996 58
Wuhan JiyunZen Tech Co., Ltd. 		+86-18062099985 Amyjiyunzen@yeah.net China 672 58
Sinoway Industrial co., ltd. 		+86-0592-5800732 +86-13806035118 xie@china-sinoway.com China 1366 58
Supplier Advantage
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shandong Huisheng Import & Export Co., Ltd. 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Hangzhou Hyper Chemicals Limited 		58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
Wuhan JiyunZen Tech Co., Ltd. 		58
Sinoway Industrial co., ltd. 		58

Related articles

View Lastest Price from Olmesartan Medoxomil manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Olmesartan medoxomil pictures 2026-08-15 Olmesartan medoxomil
144689-63-4
 0.99 RongNa Biotechnology Co.,Ltd
Olmesartan Medoxomil pictures 2026-08-14 Olmesartan Medoxomil
144689-63-4
 25Kg/Bag CEP/EP 20 tons Sinoway Industrial co., ltd.
Olmesartan Medoxomil pictures 2026-08-14 Olmesartan Medoxomil
144689-63-4
 $750.00-980.00 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Olmesartan Medoxomil Spectrum

Olmesartan Medoxomil(144689-63-4)1HNMR

144689-63-4(Olmesartan Medoxomil)Related Search:

Olmesartan OlMesartan Lactone IMpurity 1-(4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazol-5-yl)ethanone Losartan potassium Irbesartan
Olmesartan Rebeprazole sodium Valganciclovir hydrochloride n-Butyl OlMesartan MedoxoMil 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester
Anastrozole Tasosartan EPROSARTAN 4,5-Bismethylene-1,3-dioxolan-2-one Dehydro Olmesartan
OlMesartan MedoxoMil Ethyl Methyl Analog Diethyl 2-propylImidazoledicarbonate OlMesartan MedoxoMil Butyl IMpurity

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(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl] 4-yl)methyl)-4-( OlMesartan MedoxoMil SynoyM:4-(1-Hydroxy-1-Methylethyl)-2-propyl-1-[[2'-(1H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-iMidazole-5-carboxylic acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester OLMESARTAN MEDOXOMIL USP ORGANIC CHEMICA OMST Olmesartan medoxomil for system suitability Olmesartan MedoxomiI (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hyd 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolecarboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl-1H-Imidazole-5-carboxylic acid, (5-methyl -2-oxo-1,3-dioxol-4-yl) methyl ester OlmesartanC29H30N6O6 CS-866, 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2(1H-tetazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester Oimesartan 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylicacid(5-Methyl-2-oxo-1,3-dioxol-4-yl)methylester CS-866 Olmesartan medoxomil Olmetec 5-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-3-[2''-(1H-TETRAZOL-5-YL)-BIPHENYL-4-YLMETHYL]-3H-IMIDAZOLE-4-CARBOXYLIC ACID 5-METHYL-2-OXO-[1,3]DIOXOL-4-YLMETHYL ESTER 5-(1-Hydroxy-1-methylethyl)-2-propyl-3-[2'-(1H-tet Sanguisorba officinalis L. Olmesartan Medoxomil (100 mg) (5-Methyl-2-oxo-2H-1,3-dioxol-4-yl)Methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1H-iMidazole-5-carboxylate OlMesartan MedoxoMil (Benicar) (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-iMidazole-5-carboxylate Olmesartan medoxomil CRS Olmesartan medoxomil for system suitability CRS Olmesartan Medoxomil RS olmesartan medoxomil olmetec 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1h-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl esterEuEE Olmesartan Medoxomil USP/EP/BP olmesartan medoxomil olmetec 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2’-(1h-tetazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl esterEuEEuE Olmesartan Medoxomil-USP 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2’-(2H-tetazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2Htetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate Good Quality Olmesartan Medoxomil CAS?144689-63-4?Omst for Anti-Hypertensive (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate Olmesartan Medoxomil (CS 866) Olmesartan medoxomil (Y0001405) Olmesartan MedoxomilQ: What is Olmesartan Medoxomil Q: What is the CAS Number of Olmesartan Medoxomil Q: What is the storage condition of Olmesartan Medoxomil Olmesartan Medoxomil (1478367) Benzenesulfonylchloride,8-(acetylamino)- Olmesartan Medoxomile OLMESARTAN MEDOXOMIL 13.33 % GRANULES OLEMISARTAN MEDAXMIL Olmesartan Medoxomil (5-Methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan- 2-yl)-2-propyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5- yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylate Olmesartan medoxomil API Omesartan ester Olmesartn Medoxomil Olmesartan Medoxomil, 10 mM in DMSO 1H-imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester Olmesartan Medoxomil: (5-Methyl-2-oxo-1,3-dioxol-4-yl) methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carboxylate 4-(1-Hydroxy-isopropyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)-biphenyl-4-yl]methyl]-1H-imidazol-5-carboxylic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)methyl ester (5-methyl-2-carbonyl-1,3-dioxy-4-yl)methyl1-((2'-(1H-tetrazole-5-yl)-[1,1'-diphenyl]4-yl)methyl)-4-(2-hydroxypropane-2-yl)-2-propyl-1H-imidazole-5-carboxylic acidester Benicar Olmesartan Medoxomi OLMESARTAN MEDOXIMIL Olmesartan API 144689-63-4 144689-63-5 C29H30N6O