4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester
- CAS No.
- 1203662-37-6
- Chemical Name:
- 4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester
- Synonyms
- 4-Bromo-1H;3,2-DIOXABOROLAN-2-YL)THIOPHEN-2-YL);tert-Butyl 4-bromo-1H-indazol-5-carboxylate;4-Bromo-5-(tert-butoxycarbonyl)-1H-indazole;tert-Butyl 4-bromo-1H-indazole-5-carboxylate;1,1-Dimethylethyl 4-bromo-1H-indazole-5-carboxylate;4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester;4-Bromo-1H-indazole-5-carboxylic acid tert-butyl ester;1H-Indazole-5-carboxylic acid, 4-broMo-, 1,1-diMethylethyl ester
- CBNumber:
- CB82554716
- Molecular Formula:
- C12H13BrN2O2
- Molecular Weight:
- 297.15
- MDL Number:
- MFCD22572308
- MOL File:
- 1203662-37-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2933998090 |
4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR305101 | tert-Butyl 4-bromo-1H-indazole-5-carboxylate >97% | 1203662-37-6 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR305101 | tert-Butyl 4-bromo-1H-indazole-5-carboxylate >97% | 1203662-37-6 | 250mg | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR305101 | tert-Butyl 4-bromo-1H-indazole-5-carboxylate >97% | 1203662-37-6 | 1g | $104 | 2026-06-04 | Buy |
| Apolloscientific | OR305101 | tert-Butyl 4-bromo-1H-indazole-5-carboxylate >97% | 1203662-37-6 | 5g | $511 | 2026-06-04 | Buy |
| Apolloscientific | OR305101 | tert-Butyl 4-bromo-1H-indazole-5-carboxylate >97% | 1203662-37-6 | 25g | $2334 | 2026-06-04 | Buy |
4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester Chemical Properties, Uses, Production
Uses
tert-Butyl 4-Bromo-1H-indazole-5-carboxylate could be prepared as inhibitors of MNK1 and MNK2, which are useful in treating MNK-mediated diseases.
Synthesis
1203662-35-4
1203662-37-6
Step 3: Synthesis of tert-butyl 4-bromo-1H-indazole-5-carboxylate [0245] Tert-butyl 2-bromo-4-fluoro-3-formylbenzoate (4.25 g, 14 mmol) was dissolved in DME (25 mL), hydrazine hydrate (15 mL) was added, and the reaction was heated for 1 hr at 90 °C. After completion of the reaction, it was cooled to room temperature and the reaction mixture was partitioned between ethyl acetate and water. The aqueous layer was extracted with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give tert-butyl 4-bromo-1H-indazole-5-carboxylate as a brown solid (4.1 g, 100% yield). LCMS (Method B): retention time (Rx) = 3.63 min, [M + CH3CN + H]+ = 338/340, [M-H] = 295/297.
References
[1] Patent: WO2010/3025, 2010, A1. Location in patent: Page/Page column 63
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 10, p. 4594 - 4604
4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16307 | 64 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Hunan HuaTeng Pharmaceutical Co., Ltd., | 400-8592883 15367835770 | sales@huatengsci.com | China | 5869 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Shanghai Rong Lin Medical Technology Co., Ltd. | 18602194589 | lincy-110@163.com | China | 874 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 87240 | 60 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7964 | 55 |
