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Sphingosine Kinase 1 Polyclonal FITC Antibody

Sphingosine Kinase 1 Polyclonal FITC Antibody structure

CAS No.

Chemical Name:: Sphingosine Kinase 1 Polyclonal FITC Antibody

Synonyms: Sphingosine Kinase 1 Polyclonal FITC Antibody

CBNumber:: CB82592552

Molecular Formula:

Molecular Weight:: 0

MDL Number:

MOL File:: Mol file

Last updated:2025-08-20 16:56:25

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Sphingosine Kinase 1 Polyclonal FITC Antibody price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10012201	Sphingosine Kinase 1 Polyclonal FITC Antibody		1ea	$388	2026-04-30	Buy

Product number	Packaging	Price	Buy
10012201	1ea	$388	Buy

Sphingosine Kinase 1 Polyclonal FITC Antibody Chemical Properties, Uses, Production

Description

The primary use of this antibody conjugate is for the detection of SPHK1 in intact cells by direct immunolabeling methods such as flow cytometry or immunofluorescence microscopy. SPHK1 is one of the enzymes involved in sphingolipid metabolism. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate. This reaction plays an important role in determining cell proliferation versus cell death. SPHK1 is found in a wide variety of tissues and cell types including kidney, liver, spleen, heart, platelets, and human tumors. On a cellular level, it is found in the cytosolic and membrane fractions. Based on the amino acid sequence, this protein has a molecular weight of approximately 43 kDa. Some reported post translational modifications may explain the shift in band migration to 50 kDa. NOTE: Multiple isoforms of SPHK1 are known and one is 470 amino acids. This likely explains the 50 kDa band observed.

References

[1] CHRISTINE DELON. Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.[J]. The Journal of Biological Chemistry, 2004, 279 43: 44763-44774. DOI: 10.1074/jbc.m405771200
[2] A. H. MERRILL. Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.[J]. Environmental Health Perspectives, 2001, 22 1: 283-289. DOI: 10.1289/ehp.01109s2283
[3] JIN-WOOK KIM . Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases[J]. Bioorganic & Medicinal Chemistry, 2005, 13 10: Pages 3475-3485. DOI: 10.1016/j.bmc.2005.02.053
[4] MICHAEL MACEYKA. SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.[J]. The Journal of Biological Chemistry, 2005, 280 44: 37118-37129. DOI: 10.1074/jbc.m502207200
[5] S M PITSON. Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes.[J]. Biochemical Journal, 2000, 350 Pt 2: 429-441.

Sphingosine Kinase 1 Polyclonal FITC Antibody Preparation Products And Raw materials

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Sphingosine Kinase 1 Polyclonal FITC Antibody Suppliers

Global Suppliers ( 3)

Supplier	Tel	Email	Country	ProdList	Advantage
Cayman Chemical Company	--	sales@caymanchem.com	China	6808	58
Shenzhen Campbell Biotechnology Co., Ltd.	--		CHINA	6891	58
Cayman Chemical Company	--	cayman@caymanchem.com	United States	6987	81

Supplier	Advantage
Cayman Chemical Company	58
Shenzhen Campbell Biotechnology Co., Ltd.	58
Cayman Chemical Company	81

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Sphingosine Kinase 1 Polyclonal FITC Antibody