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CEP-32496

CEP-32496 Structure
CEP-32496 structure
CAS No.
1227678-26-3
Chemical Name:
CEP-32496
Synonyms
CEP-32496;CEP-32496 HCl salt;CEP-32496 USP/EP/BP;RXDX105 hydrochloride;CEP32496 hydrochloride;RXDX 105 hydrochloride;RXDX-105 hydrochloride;CEP 32496 hydrochloride;Agerafenib hydrochloride;CEP-32496 (hydrochloride)
CBNumber:
CB82596590
Molecular Formula:
C24H23ClF3N5O5
Molecular Weight:
553.9181296
MDL Number:
MFCD22124523
MOL File:
1227678-26-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:26:50
Product description Number Pack Size Price
CEP 32496 hydrochloride FC104018 1mg $285.56
CEP 32496 hydrochloride FC104018 2mg $456.9
CEP 32496 hydrochloride FC104018 5mg $713.9
CEP 32496 hydrochloride FC104018 10mg $1142.2
CEP 32496 hydrochloride FC104018 25mg $2141.75
Request For Quotation

CEP-32496 Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
FDA UNII 8J0Y5N290S

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

CEP-32496 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FC104018 CEP 32496 hydrochloride 1227678-26-3 1mg $285.56 2026-06-04 Buy
Biosynth FC104018 CEP 32496 hydrochloride 1227678-26-3 2mg $456.9 2026-06-04 Buy
Biosynth FC104018 CEP 32496 hydrochloride 1227678-26-3 5mg $713.9 2026-06-04 Buy
Biosynth FC104018 CEP 32496 hydrochloride 1227678-26-3 10mg $1142.2 2026-06-04 Buy
Biosynth FC104018 CEP 32496 hydrochloride 1227678-26-3 25mg $2141.75 2026-06-04 Buy
Product number Packaging Price Buy
FC104018 1mg $285.56 Buy
FC104018 2mg $456.9 Buy
FC104018 5mg $713.9 Buy
FC104018 10mg $1142.2 Buy
FC104018 25mg $2141.75 Buy

CEP-32496 Chemical Properties,Uses,Production

Uses

CEP 32496 is an orally active BRAFV600E inhibitor with selective cellular and in vivo antitumor activity.

in vivo

Oral administration of Agerafenib (CEP-32496) to Colo-205 tumor xenograft-bearing mice results in significant inhibition of pMEK in tumor cell lysates. For instance, a single 30 mg/kg (po) dose of Agerafenib (CEP-32496) leads to a 50 and 75% inhibition of normalized pMEK in tumor lysates at the 2 and 6 h postdose time point, respectively (p<0.03), while a 55 mg/kg (po) dose resulted in a 75% to 57% (p<0.03) inhibition of pMEK at 2 through 10 h post administration, with normalization to baseline by 24 h. Agerafenib (CEP-32496) exhibits an exceptional PK profile in mouse, dog, and cynomolgus monkey. Administration of Agerafenib (CEP-32496) to beagle dogs (single dose of 1 mg/kg iv and 10 mg/kg po) results in low clearance (CL=5.0 (mL/min)/kg) and excellent bioavailability (%F=100). Similarly, in cynomolgus monkey, the administration of Agerafenib (CEP-32496) (single dose of 1 mg/kg iv and 10 mg/kg po) leads to high oral exposure due to low clearance (CL=6.7 mL/min/kg) and excellent bioavailability (%F=100)[1].

target

wild-type BRAF

IC 50

BRafV600E: 14 nM (Kd); Braf: 36 nM (Kd); CRAF: 39 nM (Kd); c-Kit: 2 nM (Kd); Ret: 2 nM (Kd); LCK: 2 nM (Kd); Abl-1: 3 nM (Kd); VEGFR-2: 8 nM (Kd); CSF-1R: 9 nM (Kd); EPHA2: 14 nM (Kd); EGFR: 22 nM (Kd); c-Met: 513 nM (Kd); JAK-2: 4700 nM (Kd); MEK-1: 7100 nM (Kd); MEK-2: 8300 nM (Kd)

CEP-32496 Preparation Products And Raw materials

Raw materials

Preparation Products

CEP-32496 Suppliers

Global( 80)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 28292 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19853 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131956 58
China Langchem Inc. 0086-21-58956006 China 7811 57
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2782 58
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1785 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
BOC Sciences 		58
Amadis Chemical Company Limited 		58
China Langchem Inc. 57
MedChemexpress LLC 58
AdooQ BioScience, LLC 58
CEG Chemical Science&Technology Co., Ltd. 58
LETOPHARM LIMITED 58

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CEP-32496 1-(3-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-Methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride CEP 32496 hydrochloride CEP-32496 (hydrochloride) CEP32496 hydrochloride CEP-32496 HCl salt 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxaz N-[3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]urea hydrochloride Agerafenib (CEP-32496) HCl Agerafenib hydrochloride CEP 32496 HYDROCHLORIDE;CEP32496 HYDROCHLORIDE;RXDX105 HYDROCHLORIDE;RXDX 105 HYDROCHLORIDE;RXDX-105 HYDROCHLORIDE;AGERAFENIB HYDROCHLORIDE RXDX 105 hydrochloride RXDX105 hydrochloride RXDX-105 hydrochloride CEP 32496 HYDROCHLORIDE; CEP32496 HYDROCHLORIDE Agerafenib (CEP-32496) hydrochloride CEP-32496 USP/EP/BP 1227678-26-3 C24H23ClF3N5O5 C24H22F3N5O5HCl