CEP-32496
- CAS No.
- 1227678-26-3
- Chemical Name:
- CEP-32496
- Synonyms
- CEP-32496;CEP-32496 HCl salt;CEP-32496 USP/EP/BP;RXDX105 hydrochloride;CEP32496 hydrochloride;RXDX 105 hydrochloride;RXDX-105 hydrochloride;CEP 32496 hydrochloride;Agerafenib hydrochloride;CEP-32496 (hydrochloride)
- CBNumber:
- CB82596590
- Molecular Formula:
- C24H23ClF3N5O5
- Molecular Weight:
- 553.9181296
- MDL Number:
- MFCD22124523
- MOL File:
- 1227678-26-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Powder |
| FDA UNII | 8J0Y5N290S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
CEP-32496 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FC104018 | CEP 32496 hydrochloride | 1227678-26-3 | 1mg | $285.56 | 2026-06-04 | Buy |
| Biosynth | FC104018 | CEP 32496 hydrochloride | 1227678-26-3 | 2mg | $456.9 | 2026-06-04 | Buy |
| Biosynth | FC104018 | CEP 32496 hydrochloride | 1227678-26-3 | 5mg | $713.9 | 2026-06-04 | Buy |
| Biosynth | FC104018 | CEP 32496 hydrochloride | 1227678-26-3 | 10mg | $1142.2 | 2026-06-04 | Buy |
| Biosynth | FC104018 | CEP 32496 hydrochloride | 1227678-26-3 | 25mg | $2141.75 | 2026-06-04 | Buy |
CEP-32496 Chemical Properties, Uses, Production
Uses
CEP 32496 is an orally active BRAFV600E inhibitor with selective cellular and in vivo antitumor activity.
in vivo
Oral administration of Agerafenib (CEP-32496) to Colo-205 tumor xenograft-bearing mice results in significant inhibition of pMEK in tumor cell lysates. For instance, a single 30 mg/kg (po) dose of Agerafenib (CEP-32496) leads to a 50 and 75% inhibition of normalized pMEK in tumor lysates at the 2 and 6 h postdose time point, respectively (p<0.03), while a 55 mg/kg (po) dose resulted in a 75% to 57% (p<0.03) inhibition of pMEK at 2 through 10 h post administration, with normalization to baseline by 24 h. Agerafenib (CEP-32496) exhibits an exceptional PK profile in mouse, dog, and cynomolgus monkey. Administration of Agerafenib (CEP-32496) to beagle dogs (single dose of 1 mg/kg iv and 10 mg/kg po) results in low clearance (CL=5.0 (mL/min)/kg) and excellent bioavailability (%F=100). Similarly, in cynomolgus monkey, the administration of Agerafenib (CEP-32496) (single dose of 1 mg/kg iv and 10 mg/kg po) leads to high oral exposure due to low clearance (CL=6.7 mL/min/kg) and excellent bioavailability (%F=100)[1].
target
wild-type BRAF
IC 50
BRafV600E: 14 nM (Kd); Braf: 36 nM (Kd); CRAF: 39 nM (Kd); c-Kit: 2 nM (Kd); Ret: 2 nM (Kd); LCK: 2 nM (Kd); Abl-1: 3 nM (Kd); VEGFR-2: 8 nM (Kd); CSF-1R: 9 nM (Kd); EPHA2: 14 nM (Kd); EGFR: 22 nM (Kd); c-Met: 513 nM (Kd); JAK-2: 4700 nM (Kd); MEK-1: 7100 nM (Kd); MEK-2: 8300 nM (Kd)
CEP-32496 Preparation Products And Raw materials
Raw materials
Preparation Products
CEP-32496 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1784 | 58 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| Tongling HengYou Biotechnology Co., Ltd. | 021-50426030 13856289449;13124863828 | 2630597085@qq.com | China | 1885 | 55 |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 645 | 55 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4975 | 55 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
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