N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride
![N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride Structure](CAS/GIF/1262036-49-6.gif)
- CAS No.
- 1262036-49-6
- Chemical Name:
- N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride
- Synonyms
- LY 2886721 hydrochloride;LY 2886721 hydrochloride salt;N-(3-((4aS,7aS)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride;N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride
- CBNumber:
- CB82604240
- Molecular Formula:
- C18H16F2N4O2S.HCl
- Molecular Weight:
- 426.8679864
- MDL Number:
- MFCD24387533
- MOL File:
- 1262036-49-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| LY2886721Hydrochloride ≥98%(HPLC) | 7081 | 50 | $905 |
| LY2886721hydrochloride 99% | Axon1964 | 5mg | $115.5 |
| LY 2886721 hydrochloride | FL104248 | 10mg | $185 |
| LY-2886721hydrochloride | 4679DH | 10mg | $299 |
| LY2886721hydrochloride 99% | Axon1964 | 25mg | $401.5 |
N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride Properties
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO|42.69|100| |
| FDA UNII | HW8GJY7V7R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 7081 | LY2886721Hydrochloride ≥98%(HPLC) | 1262036-49-6 | 50 | $905 | 2021-12-16 | Buy |
| Axon Medchem | Axon1964 | LY2886721hydrochloride 99% | 1262036-49-6 | 5mg | $115.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL104248 | LY 2886721 hydrochloride | 1262036-49-6 | 10mg | $185 | 2021-12-16 | Buy |
| AK Scientific | 4679DH | LY-2886721hydrochloride | 1262036-49-6 | 10mg | $299 | 2021-12-16 | Buy |
| Axon Medchem | Axon1964 | LY2886721hydrochloride 99% | 1262036-49-6 | 25mg | $401.5 | 2021-12-16 | Buy |
N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride Chemical Properties,Uses,Production
Uses
LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 hydrochloride is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment[1].
in vivo
LY2886721 hydrochloride (3-30 mg/kg; oral administration; PDAPP mice) treatment significantly reduces the hippocampal and cortical levels of Aβ1-x. LY2886721 hydrochloride treatment results in significant reduction of brain parenchymal levels of C99 and sAPPβ[1].
storage
Store at -20°C
References
[1] May PC1, et al. The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans. J Neurosci. 2015 Jan 21;35(3):1199-210. DOI:10.1523/JNEUROSCI.4129-14.2015
N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride Preparation Products And Raw materials
N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4769 | 55 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7778 | 56 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9756 | 58 |
View Lastest Price from N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-12 | LY 2886721 Hydrochloride
1262036-49-6
|
US $968.00-3970.00 / mg | 10g | TargetMol Chemicals Inc. |
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- LY 2886721 Hydrochloride
1262036-49-6
- US $968.00-3970.00 / mg
- TargetMol Chemicals Inc.
