Quinoline, 7-broMo-4-Methyl-
- CAS No.
- 141052-31-5
- Chemical Name:
- Quinoline, 7-broMo-4-Methyl-
- Synonyms
- CAS:141052-31-5;4-Methyl-7-broMoquinoline;4-Methyl-7-broMoquinazoline;Quinoline, 7-broMo-4-Methyl-
- CBNumber:
- CB82624862
- Molecular Formula:
- C10H8BrN
- Molecular Weight:
- 222.08
- MDL Number:
- MFCD18204665
- MOL File:
- 141052-31-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Quinoline, 7-broMo-4-Methyl- price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS41227 | 7-Bromo-4-methylquinoline 98% | 141052-31-5 | 1g | $95 | 2026-06-04 | Buy |
| Activate Scientific | AS41227 | 7-Bromo-4-methylquinoline 98% | 141052-31-5 | 5g | $474 | 2026-06-04 | Buy |
| Matrix Scientific | 132218 | 7-Bromo-4-methylquinoline | 141052-31-5 | 250.00mg | $23 | 2026-05-18 | Buy |
| Matrix Scientific | 132218 | 7-Bromo-4-methylquinoline | 141052-31-5 | 1.00g | $81 | 2026-05-18 | Buy |
| Matrix Scientific | 132218 | 7-Bromo-4-methylquinoline | 141052-31-5 | 5.00g | $390 | 2026-05-18 | Buy |
Quinoline, 7-broMo-4-Methyl- Chemical Properties, Uses, Production
Synthesis
78-94-4
141052-31-5
Concentrated sulfuric acid (14.4 mL, 270 mmol) was slowly added to a 1,4-dioxane (1 L) solution of 3-bromoaniline (30.0 g, 174 mmol) at room temperature. The reaction mixture was heated to reflux and a 1,4-dioxane (50 mL) solution of methyl vinyl ketone (19.5 mL, 270 mmol) was added dropwise over 3 hours. After the dropwise addition, the reflux reaction was continued for 1 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in water (100 mL), neutralized with sodium carbonate to neutral, and subsequently extracted with dichloromethane. The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and the resulting crude product was purified by silica gel column chromatography (Biotage system, eluent 20% ethyl acetate/hexane) to afford 4-methyl-7-bromoquinoline (15.0 g, 43% yield) as a brown solid.1H NMR (CDCl3) δ: 8.80-8.75 (m, 1H), 8.30 (s, 1H), 7.90-7.85 (m , 1H), 7.70-7.65 (m, 1H), 7.25-7.20 (m, 1H), 2.65 (s, 3H).
References
[1] Patent: WO2004/48383, 2004, A1. Location in patent: Page 40-41
Quinoline, 7-broMo-4-Methyl- Preparation Products And Raw materials
Quinoline, 7-broMo-4-Methyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| Runpharm Technology Limited | 18171398856 2968382473 | service@runpharm.com | China | 716 | 55 |
| Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd. | 0515-89701588 13770166955 | orgunion@orgunion.com | China | 620 | 55 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| NovoChemy Ltd. | 86-(0)21-31261262 373522135 | sales@novochemy.com | China | 6491 | 58 |
| Yancheng KangdiSen Pharmaceutical Co., Ltd. | 13812573443;18052965989 | tongbenwan22@163.com | China | 1975 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
