5-Fluoro-2-methylaniline
- CAS No.
- 367-29-3
- Chemical Name:
- 5-Fluoro-2-methylaniline
- Synonyms
- 2-AMINO-4-FLUOROTOLUENE;2-METHYL-5-FLUOROANILINE;2-Amino-4-fluorotoluene~5-Fluoro-o-toluidine;TIMTEC-BB SBB004266;5-Fluoro-2-methylani;5-Fluoro-2-toluidine;Fluoromethylaniline7;5-FLUORO-O-TOLUIDINE;4-Fluoro-2-Aminotoluene;2-Ankyl-4-fluorotoluene
- CBNumber:
- CB8263018
- Molecular Formula:
- C7H8FN
- Molecular Weight:
- 125.14
- MDL Number:
- MFCD00007764
- MOL File:
- 367-29-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Fluoro-2-methylaniline 99% | F10402 | 10g | $31.8 |
| 5-Fluoro-2-methylaniline >98.0%(GC) | F0232 | 5g | $24 |
| 5-Fluoro-2-methylaniline >98.0%(GC) | F0232 | 25g | $69 |
| 5-Fluoro-2-methylaniline 97% | PC49276 | 100g | $37 |
| 5-Fluoro-2-methylaniline 97% | PC49276 | 500g | $115 |
| More product size | |||
| Melting point | 38-40 °C (lit.) |
|---|---|
| Boiling point | 98-100°C 15mm |
| Density | 1.13 g/cm3 (20℃) |
| refractive index | 1.538 |
| Flash point | 194 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| form | Crystalline Solid or Liquid |
| pka | 3.44±0.10(Predicted) |
| color | Purple to brown |
| Water Solubility | insoluble |
| BRN | 2637584 |
| InChI | InChI=1S/C7H8FN/c1-5-2-3-6(8)4-7(5)9/h2-4H,9H2,1H3 |
| InChIKey | JLCDTNNLXUMYFQ-UHFFFAOYSA-N |
| SMILES | C1(N)=CC(F)=CC=C1C |
| CAS DataBase Reference | 367-29-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 5-Fluoro-2-methylaniline(367-29-3) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS06,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335-H302-H311-H332-H373 | |||||||||
| Precautionary statements | P261-P280-P301+P312+P330-P305+P351+P338-P260-P304+P340-P405-P501a-P264-P270-P271-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38-23/24/25 | |||||||||
| Safety Statements | 26-27-36/37/39-45-36 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Toxic/Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214300 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 1.0 Kg (2.2 lbs) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
5-Fluoro-2-methylaniline price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F10402 | 5-Fluoro-2-methylaniline 99% | 367-29-3 | 10g | $31.8 | 2023-01-07 | Buy |
| TCI Chemical | F0232 | 5-Fluoro-2-methylaniline >98.0%(GC) | 367-29-3 | 5g | $24 | 2026-04-30 | Buy |
| TCI Chemical | F0232 | 5-Fluoro-2-methylaniline >98.0%(GC) | 367-29-3 | 25g | $69 | 2026-04-30 | Buy |
| Apolloscientific | PC49276 | 5-Fluoro-2-methylaniline 97% | 367-29-3 | 100g | $37 | 2026-06-04 | Buy |
| Apolloscientific | PC49276 | 5-Fluoro-2-methylaniline 97% | 367-29-3 | 500g | $115 | 2026-06-04 | Buy |
5-Fluoro-2-methylaniline Chemical Properties,Uses,Production
Chemical Properties
purple to brown crystalline solid
Uses
Used as a pharmaceutical intermediate in organic synthesis.
Synthesis
In a nitrogen-fed glovebox, Pd(P(o-tol)3)2 and CyPF-PtBu (1:1 ratio) were dissolved in dioxane and mixed for 5 min. A 20 mL scintation vial was charged with aryl halide (0.60 mmol, 1 equiv), ammonium sulfate (0.90 mmol, 1.5 equiv), and sodium tert-butoxide (2.7 mmol, 4.5 equiv). To this vial was added 6 mL of anhydrous dioxane and the appropriate amount of catalyst from the stock solution. The reaction vial was sealed with a Teflon-lined screw cap and removed from the glovebox. The reaction was stirred at the desired temperature for 12 h. The reaction mixture was diluted with EtOAc and filtered through a pad of Celite. The filtrate was concentrated in vacuo, and the crude product was purified by flash column chromatography. 5-Fluoro-2-methylaniline (Table 3, 2s) (CAS: 367-29-3) The reaction to form this product was conducted with 0.5 mol % Pd(P(o-tol)3)2 and 0.5 mol % CyPF-PtBu for 8 h. The crude product was isolated by flash column chromatography (5:1 Hexanes:EtOAc). 5-Fluoro-2-methylaniline was isolated as an oil in 76% yield. 1(600 MHz, CDCl3): δ 6.97 (t, J= 7.2 Hz, 1H), 6.40 (t, J= 9.9 Hz, 2H), 3.69 (s, 2H), 2.12 (s, 3H). 13C-NMR(151 MHz, CDCl3): δ 162.24 (d, JC-F= 240.9 Hz), 145.82 (d, JC-F= 10.6 Hz), 131.12 (d, JC-F= 9.6 Hz), 117.62 (d, JC-F = 2.6 Hz), 104.67 (d, JC-F= 21.0 Hz), 101.56 (d, JC-F= 24.6 Hz), 16.62 (s).
References
[1] Journal of Organic Chemistry, 1992, vol. 57, # 19, p. 5254 - 5255
[2] Patent: WO2015/104662, 2015, A1. Location in patent: Page/Page column 37
[3] Patent: US2016/326151, 2016, A1. Location in patent: Paragraph 0204
[4] Journal of the American Chemical Society, 1948, vol. 70, p. 439
[5] Journal of the Chemical Society, 1953, p. 3326
5-Fluoro-2-methylaniline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3997 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
View Lastest Price from 5-Fluoro-2-methylaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-12-01 | 5-Fluoro-2-methylaniline
367-29-3
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 5-Fluoro-2-methylaniline
367-29-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-06-18 | 5-Fluoro-2-methylaniline
367-29-3
|
$1.00 | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd |
-
- 5-Fluoro-2-methylaniline
367-29-3
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-Fluoro-2-methylaniline
367-29-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-Fluoro-2-methylaniline
367-29-3
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
