Mito-TEMPO
- CAS No.
- 1334850-99-5
- Chemical Name:
- Mito-TEMPO
- Synonyms
- MitoTEMP0;Mito-TEMPO;SML0737-5MG;MitoTEMPO >=98% (HPLC);Mito-TEMPO, 10 mM in DMSO;MitoTEMPO, a mitochondrial targeted antioxidant;(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride;1-Piperidinyloxy, 2,2,6,6-tetramethyl-4-[[2-(triphenylphosphonio)acetyl]amino]-, chloride (1:1);inhibit,Mito-TEMPO,Mitochondrial Metabolism,Reactive Oxygen Species,MitoTEMPO,Mito TEMPO,Inhibitor
- CBNumber:
- CB82645108
- Molecular Formula:
- C29H35N2O2P
- Molecular Weight:
- 510.03
- MDL Number:
- MFCD26406410
- MOL File:
- 1334850-99-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| MitoTEMPO ≥98% (HPLC) | SML0737 | 5mg | $86.16 |
| MitoTEMPO ≥98% (HPLC) | SML0737 | 25mg | $367 |
| Mito-TEMPO 98.05% | CS-0067207 | 50mg | $420 |
| Mito-TEMPO 98.05% | CS-0067207 | 100mg | $700 |
| Mito-TEMPO 98.05% | CS-0067207 | 10mg | $110 |
| storage temp. | -20°C |
|---|---|
| solubility | H2O: soluble10mg/mL, clear |
| form | powder |
| color | white to light brown |
| Water Solubility | H2O: 10mg/mL, clear |
| Stability | Stable for 2 years from date of purchase as supplied |
| InChI | InChI=1S/C29H34N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23H,20-22H2,1-4H3;1H |
| InChIKey | WKKFJIJNGHNQQW-UHFFFAOYSA-N |
| SMILES | [P+](C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)CC(=O)NC1CC(N(C(C1)(C)C)[O])(C)C.[Cl-] |^1:31| |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Mito-TEMPO price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0737 | MitoTEMPO ≥98% (HPLC) | 1334850-99-5 | 5mg | $86.16 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0737 | MitoTEMPO ≥98% (HPLC) | 1334850-99-5 | 25mg | $367 | 2025-07-31 | Buy |
| ChemScene | CS-0067207 | Mito-TEMPO 98.05% | 1334850-99-5 | 50mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-0067207 | Mito-TEMPO 98.05% | 1334850-99-5 | 100mg | $700 | 2021-12-16 | Buy |
| ChemScene | CS-0067207 | Mito-TEMPO 98.05% | 1334850-99-5 | 10mg | $110 | 2021-12-16 | Buy |
Mito-TEMPO Chemical Properties,Uses,Production
Description
Mito-TEMPO (1334850-99-5) is a mitochondria-targeted antioxidant. Partially prevents mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery.1?Resolves mitochondrial oxidative stress and rescues coronary collateral growth in Zucker obese fatty rats.2?Protects mitochondrial membrane potential and attenuates reperfusion-induced ROS production in a mouse ventricular myocyte model.3?Abrogates the induction of senescence in a human vascular smooth muscle cell model.4
Uses
MitoTEMPO has been used as a mitochondria-targeted antioxidant.
Biochem/physiol Actions
MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide. MitoTEMPO is a combination of the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, giving MitoTEMPO the ability to pass through lipid bilayers with ease and accumulate several hundred-fold in mitochondria. Mitochondrial dysfunction and oxidative stress contribute to a variety of disorders involving cardiovascular, kidney, liver disorders, Parkinson′s and Alzheimer′s disease.
in vivo
Mito-TEMPO (MT) greatly attenuates the increase in ALT activities and reduces the areas of necrosis at both time points, indicating that the protection by Mito-TEMPO is sustained until at least 24 h post-APAP. Mito-Tempo could induce secondary apoptosis in the late phase of APAP hepatotoxicity. Mito-Tempo induces secondary apoptosis after APAP overdose by inhibition of RIP3[1].
References
[1] HUAN LING LIANG . SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery[J]. Free Radical Biology and Medicine, 2010, 49 10: Pages 1550-1560. DOI:10.1016/j.freeradbiomed.2010.08.018
[2] YUH FEN PUNG. Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats.[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2012, 32 2: 325-334. DOI:10.1161/atvbaha.111.241802
[3] JAIME DESANTIAGO Kathrin B Dan J Bare. Ischemia/Reperfusion injury protection by mesenchymal stem cell derived antioxidant capacity.[J]. Stem cells and development, 2013, 22 18: 2497-2507. DOI:10.1089/scd.2013.0136
[4] YOGITA MISTRY . A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells[J]. Redox Biology, 2013, 1 1: Pages 411-417. DOI:10.1016/j.redox.2013.08.004
Mito-TEMPO Preparation Products And Raw materials
Raw materials
Preparation Products
Mito-TEMPO Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4747 | 58 |
| Shanghai Qianhao Biotechnology Co., LTD | 13524877553 | 13524877553@163.com | China | 60 | 58 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Wuhan Sunrise Technology Development Co., Ltd. | 27-027-83314682 13554138826 | whsrtech@vip.163.com | China | 246 | 62 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3506 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
