(-)-D-PYROGLUTAMIC ACID METHYL ESTER
- CAS No.
- 64700-65-8
- Chemical Name:
- (-)-D-PYROGLUTAMIC ACID METHYL ESTER
- Synonyms
- Methyl (R)-5-oxopyrrolidine-2-carboxylate;(R)-METHYL 5-OXOPYRROLIDINE-2-CARBOXYLATE;methyl (2R)-5-oxopyrrolidine-2-carboxylate;5-Oxo-D-proline methyl ester;D-PYR-OME;Methyl D-pyroglutaMate;Methyl (R)-pyroglutamate;Methyl (R)-(-)-2-pyrrolidinone;Methyl D-Pyroglutamate,99%e.e.;D-Proline, 5-oxo-, Methyl ester
- CBNumber:
- CB8267122
- Molecular Formula:
- C6H9NO3
- Molecular Weight:
- 143.14
- MDL Number:
- MFCD01318621
- MOL File:
- 64700-65-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (R)-Methyl 5-Oxopyrrolidine-2-carboxylate | TRC-M137985-5G | 5g | $123 |
| (R)-Methyl 5-Oxopyrrolidine-2-carboxylate | TRC-M137985-2.5G | 2.5g | $78 |
| (R)-Methyl 5-Oxopyrrolidine-2-carboxylate | TRC-M137985-10G | 10g | $186 |
| (D)-Pyroglutamic acid methyl ester 98% | OR310605 | 5g | $21 |
| (D)-Pyroglutamic acid methyl ester 98% | OR310605 | 25g | $54 |
| More product size | |||
| Boiling point | 83℃/0.25mm |
|---|---|
| Density | 1.226 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Dichloromethane |
| form | Oil |
| pka | 14.65±0.40(Predicted) |
| color | Clear |
| Sensitive | Moisture Sensitive |
| InChI | InChI=1S/C6H9NO3/c1-10-6(9)4-2-3-5(8)7-4/h4H,2-3H2,1H3,(H,7,8)/t4-/m1/s1 |
| InChIKey | HQGPKMSGXAUKHT-SCSAIBSYSA-N |
| SMILES | C(OC)(=O)[C@H]1CCC(=O)N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2922500090 | |||||||||
| NFPA 704 |
|
(-)-D-PYROGLUTAMIC ACID METHYL ESTER price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M137985-5G | (R)-Methyl 5-Oxopyrrolidine-2-carboxylate | 64700-65-8 | 5g | $123 | 2026-06-03 | Buy |
| TRC | TRC-M137985-2.5G | (R)-Methyl 5-Oxopyrrolidine-2-carboxylate | 64700-65-8 | 2.5g | $78 | 2026-06-03 | Buy |
| TRC | TRC-M137985-10G | (R)-Methyl 5-Oxopyrrolidine-2-carboxylate | 64700-65-8 | 10g | $186 | 2026-06-03 | Buy |
| Apolloscientific | OR310605 | (D)-Pyroglutamic acid methyl ester 98% | 64700-65-8 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR310605 | (D)-Pyroglutamic acid methyl ester 98% | 64700-65-8 | 25g | $54 | 2026-06-04 | Buy |
(-)-D-PYROGLUTAMIC ACID METHYL ESTER Chemical Properties,Uses,Production
Uses
(R)-Methyl 5-Oxopyrrolidine-2-carboxylate, is a building block used in various chemical synthesis such as in preparation of phenylpropiolic acid derivatives as novel GPR40 agonists.
Synthesis
67-56-1
149-87-1
4931-66-2
The general procedure for the synthesis of methyl (S)-(+)-2-pyrrolidone-5-carboxylate from methanol and DL-pyroglutamic acid was as follows: DL-pyroglutamic acid (2150 g, 16.65 mol) was dissolved in a solvent mixture of methanol (2.0 L) and chloroform (2.0 L), and methanesulfonic acid (80 g, 0.83 mol) was added. This mixture was transferred to a Soxhlet extraction apparatus fitted with 3 molecular sieves and the reaction was refluxed under mechanical stirring for 5 days. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford methyl (S)-(+)-2-pyrrolidone-5-carboxylate as a yellow oil in 98% yield (16.3 mmol). The product could be used in the next reaction without further purification and its physicochemical properties were consistent with those reported in the literature.1H NMR (CDCl3, 400 MHz) δ ppm: 2.08-2.50 (m, 4H, CHCH2CH2), 3.77 (s, 3H, CH3), 4.29 (m, 1H, CH2CH2CH), 7.62 (br s, 1H, NH). NH).
References
[1] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 4, p. 1143 - 1146
[2] Synthesis (Germany), 2016, vol. 48, # 14, p. 2226 - 2244
[3] Journal of the American Chemical Society, 1987, vol. 109, # 25, p. 7925 - 7926
[4] Chemistry - A European Journal, 2005, vol. 11, # 8, p. 2577 - 2590
[5] Patent: EP2098526, 2009, A1. Location in patent: Page/Page column 13
(-)-D-PYROGLUTAMIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9333 | 58 |
| Wuhan Konberd Biotech Co., Ltd | +undefined18986093962 | admin@konberdbio.com | China | 1378 | 58 |
| Shanghai Scochem Technology Co., Ltd | +86-021-33758897 +86-13701882790 | sales@scochem.com | China | 1977 | 58 |
View Lastest Price from (-)-D-PYROGLUTAMIC ACID METHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-26 | (-)-D-PYROGLUTAMIC ACID METHYL ESTER
64700-65-8
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- (-)-D-PYROGLUTAMIC ACID METHYL ESTER
64700-65-8
- $1.00
- 99%
- Career Henan Chemical Co
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