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(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE structure

CAS No.: 1218935-59-1

Chemical Name:: (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE

Synonyms: (R)-2-(2,5-difluorophenyl)pyrrolidine;Larotrectinib Pyrrolidine Impurity;(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE;(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE-HCL;Pyrrolidine, 2-(2,5-difluorophenyl)-, (2R)-;(2R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride;Larotrectinib Impurity 7（Larotrectinib Pyrrolidine Impurity）;(2R)-2-(2,5-difluorophenyl)pyrrolidine, (2R,3R)-2,3-bis[(4-methoxybenzoyl)oxy]butanedioic acid

CBNumber:: CB8277099

Molecular Formula:: C10H11F2N

Molecular Weight:: 183.2

MDL Number:: MFCD07772701

MOL File:: Mol file

MSDS File:: SDS

Last updated:2026-03-18 11:52:23

Product description	Number	Pack Size	Price
(2R)-2-(2,5-Difluorophenyl)pyrrolidine	D447875	1g	$560
(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE 95.00%	CCH0038652	0.25G	$326
(2R)-2-(2,5-Difluorophenyl)pyrrolidine 95%	CM198812	1g	$407
(R)-2-(2,5-Difluorophenyl)pyrrolidine	1218935591	1g	$435
(2R)-2-(2,5-difluorophenyl)pyrrolidine 95%	K12111	250MG	$115
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(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE Properties

Boiling point	213.5±40.0 °C(Predicted)
Density	1.164±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	9.02±0.10(Predicted)
Appearance	Light yellow to yellow Liquid
FDA UNII	RPF7VP5RFX

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D447875	(2R)-2-(2,5-Difluorophenyl)pyrrolidine	1218935-59-1	1g	$560	2021-12-16	Buy
American Custom Chemicals Corporation	CCH0038652	(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE 95.00%	1218935-59-1	0.25G	$326	2021-12-16	Buy
Chemenu	CM198812	(2R)-2-(2,5-Difluorophenyl)pyrrolidine 95%	1218935-59-1	1g	$407	2021-12-16	Buy
Alichem	1218935591	(R)-2-(2,5-Difluorophenyl)pyrrolidine	1218935-59-1	1g	$435	2021-12-16	Buy
ACHEMBLOCK	K12111	(2R)-2-(2,5-difluorophenyl)pyrrolidine 95%	1218935-59-1	250MG	$115	2021-12-16	Buy

Product number	Packaging	Price	Buy
D447875	1g	$560	Buy
CCH0038652	0.25G	$326	Buy
CM198812	1g	$407	Buy
1218935591	1g	$435	Buy
K12111	250MG	$115	Buy

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE Chemical Properties,Uses,Production

Uses

(2R)-2-(2,5-Difluorophenyl)pyrrolidine is used in the synthesis of imidazo[1,2-b]pyridazine compounds as inhibitors of Trk kinases.

Synthesis

Pyrrolidine, 2-(2,5-difluorophenyl)-1-[(S)-(1,1-dimethylethyl)sulfinyl]-, (2R)-

1443538-31-5

1218935-59-1

GENERAL STEPS: To a solution of (R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine (8.60 g, 29.9 mmol) in methanol (60 mL) was slowly added a dioxane solution (37.4 mL, 150 mmol) of 4M hydrochloric acid at 0 °C. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the mixture was concentrated under vacuum and the residue was dissolved in water (100 mL) and washed with ethyl acetate (100 mL). The aqueous layer was separated and neutralized with 1N aqueous sodium hydroxide (150 mL) followed by extraction with dichloromethane (100 mL × 3). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford (R)-2-(2,5-difluorophenyl)pyrrolidine (5.06 g, 92% yield) as a slightly reddish oil.1H-NMR (CDCl3, Varian, 400 MHz): δ 1.56-1.65 (1H, m), 1.78-1.93 (3H m), 2.21-2.30 (1H, m), 3.01-3.08 (1H, m), 3.13-3.18 (1H, m), 4.39 (1H, t, J = 7.6 Hz), 6.82-6.88 (1H, m), 6.91-6.97 (1H, m), 7.22-7.26 (1H, m).

References

[1] Patent: CN107286070, 2017, A. Location in patent: Paragraph 0079; 0080; 0081
[2] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0207; 0215; 0216
[3] Patent: CN109053525, 2018, A. Location in patent: Paragraph 0021; 0031; 0032; 0033
[4] Patent: CN108003161, 2018, A. Location in patent: Paragraph 0324; 0325; 0345-0347

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE synthesis

Synthesis of (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE from 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE Preparation Products And Raw materials

Raw materials

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole Pyrrolidine, 2-(2,5-difluorophenyl)-1-[(S)-(1,1-dimethylethyl)sulfinyl]-, (2R)- (R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE (R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate Methanol

Hydrochloric acid 1,4-Dioxane

1of2

Preparation Products

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine Larotrectinib Sulfate

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE Suppliers

Global( 170)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	sales01@jndxj.com	China	298	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2949	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
PharmOrgSyn Laboratories Co., Ltd.	+86-021-38228826 +86-13916602830	sales@pharmorgsyn.cn	China	139	58

Supplier	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	55
ATK CHEMICAL COMPANY LIMITED	60
Anhui Dexinjia Biopharm Co., Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58
Standardpharm Co. Ltd.	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
PharmOrgSyn Laboratories Co., Ltd.	58

View Lastest Price from (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-20	(2R)-2-(2,5-Difluorophenyl)pyrrolidine 1218935-59-1	US $0.00 / KG	1KG	0.99	200kg	Hebei Yanxi Chemical Co., Ltd.
2025-04-04	(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE 1218935-59-1	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-11-26	(2R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride 1218935-59-1	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd

(2R)-2-(2,5-Difluorophenyl)pyrrolidine
1218935-59-1
US $0.00 / KG
0.99
Hebei Yanxi Chemical Co., Ltd.

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE
1218935-59-1
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

(2R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride
1218935-59-1
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE Spectrum

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE(1218935-59-1)¹HNMR

1218935-59-1((2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE)Related Search:

TRIS(PENTAFLUOROPHENYL)PHOSPHINE 1-Methylpyrrolidine (R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE (2R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE-HCL (R)-2-(2,5-difluorophenyl)pyrrolidine Pyrrolidine, 2-(2,5-difluorophenyl)-, (2R)- Larotrectinib Impurity 7（Larotrectinib Pyrrolidine Impurity） Larotrectinib Pyrrolidine Impurity (2R)-2-(2,5-difluorophenyl)pyrrolidine, (2R,3R)-2,3-bis[(4-methoxybenzoyl)oxy]butanedioic acid 1218935-59-1