2-Chloro-5-iodobenzoic acid
- CAS No.
- 19094-56-5
- Chemical Name:
- 2-Chloro-5-iodobenzoic acid
- Synonyms
- SOTA-011;BUTTPARK 100\01-43;Englitin Impurity 13;Chloro-5-iodobenzoicA;3-Oxetanol,9-ethynyl-;Dagliar Net Impurity 69;2-Chloro-5-iodobenoicacid;2-Chloro-5-Iodbenzoic acid;2-CHLORO-5-IODOBENZOIC ACID;2-choloro-5-iodobenzoicacid
- CBNumber:
- CB8283498
- Molecular Formula:
- C7H4ClIO2
- Molecular Weight:
- 282.46
- MDL Number:
- MFCD00079731
- MOL File:
- 19094-56-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Chloro-5-iodobenzoic acid 97% | 631736 | 25g | $85 |
| 2-Chloro-5-iodobenzoic acid 97% | 631736 | 5g | $27 |
| 2-Chloro-5-iodobenzoic Acid >97.0%(GC)(T) | C2168 | 5g | $71 |
| 2-Chloro-5-iodobenzoic Acid >97.0%(GC)(T) | C2168 | 25g | $212 |
| 2-Chloro-5-iodobenzoic acid | C367570 | 25g | $95 |
| More product size | |||
| Melting point | 157-161 °C (lit.) |
|---|---|
| Boiling point | 353.1±27.0 °C(Predicted) |
| Density | 2.077±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 2.53±0.25(Predicted) |
| form | powder to crystal |
| color | Yellow to light brown crystals or crystalline powder (light sensitive) |
| Sensitive | Light Sensitive |
| BRN | 2254110 |
| InChI | InChI=1S/C7H4ClIO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11) |
| InChIKey | GEBYSTBEDVQOTK-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(I)=CC=C1Cl |
| CAS DataBase Reference | 19094-56-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H318-H400 | |||||||||
| Precautionary statements | P273-P280-P301+P310+P330-P305+P351+P338+P310 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,N,Xi | |||||||||
| Risk Statements | 25-41-50/53 | |||||||||
| Safety Statements | 26-39-45-60-61 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 Eye Dam. 1 |
|||||||||
| NFPA 704 |
|
2-Chloro-5-iodobenzoic acid price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 631736 | 2-Chloro-5-iodobenzoic acid 97% | 19094-56-5 | 25g | $85 | 2026-03-19 | Buy |
| Sigma-Aldrich | 631736 | 2-Chloro-5-iodobenzoic acid 97% | 19094-56-5 | 5g | $27 | 2023-06-20 | Buy |
| TCI Chemical | C2168 | 2-Chloro-5-iodobenzoic Acid >97.0%(GC)(T) | 19094-56-5 | 5g | $71 | 2026-03-19 | Buy |
| TCI Chemical | C2168 | 2-Chloro-5-iodobenzoic Acid >97.0%(GC)(T) | 19094-56-5 | 25g | $212 | 2026-03-19 | Buy |
| TRC | C367570 | 2-Chloro-5-iodobenzoic acid | 19094-56-5 | 25g | $95 | 2021-12-16 | Buy |
2-Chloro-5-iodobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
2-Chloro-5-iodobenzoic Acid is a useful synthetic intermediate. It is used to prepare metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM). It is also used to synthesize quinolone carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase.
Synthesis
89-54-3
19094-56-5
The general procedure for the synthesis of 2-chloro-5-iodobenzoic acid from 5-amino-2-chlorobenzoic acid was as follows: 123 g of 2-chloro-5-aminobenzoic acid was added to 2000 g of 20% aqueous sulfuric acid solution, and the temperature of the reaction was maintained at 0 to 10 °C. An aqueous sodium nitrite solution (51 g sodium nitrite dissolved in 200 g water) was prepared and added drop by drop to the reaction system, and the progress of the reaction was monitored by TLC (unfolding agent ratio of petroleum ether/ethyl acetate = 1:3) during the reaction. Upon completion of the reaction, 1.2 g of urea was added and cooled to 0 °C with stirring, potassium iodide solution (130 g KI dissolved in 500 g of water) was quickly added and stirring was continued until no bubbles were produced and then stirred for 30 min. The reaction mixture was filtered and washed with 200 g of water to give a brown solid. The solid was dissolved in 400 g of ethyl acetate and washed sequentially with 300 mL of 1N hydrochloric acid, 300 mL of 10% sodium bisulfite solution and 400 mL of saturated brine, and the organic phase was dried with magnesium sulfate. After drying, the crude product was obtained by concentration under reduced pressure at 50 °C. The crude product was dissolved in 400 mL of toluene and heated at 80 °C for 1 hour, then cooled to 0-5 °C for 1 hour for crystallization. Finally, it was dried under reduced pressure at 50 °C to give 191 g of 2-chloro-5-iodobenzoic acid as a pale yellow solid with 99.6% purity and 93.7% yield.
References
[1] Patent: CN106748721, 2017, A. Location in patent: Paragraph 0031; 0032
[2] RSC Advances, 2017, vol. 7, # 86, p. 54881 - 54891
2-Chloro-5-iodobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ANHUI CHICO CHEMICAL CO., LTD. | +8613057662806 | kirsten@chicopharm.com | China | 2393 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +8618627948422 | sale@hdimpurity.com | China | 3681 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
View Lastest Price from 2-Chloro-5-iodobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | 2-Chloro-5-iodobenzoic acid
19094-56-5
|
US $1000.00-400.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-03-20 | 2-Chloro-5-iodobenzoic acid
19094-56-5
|
US $10.00 / KG | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-03-12 | Dapagliflozin Impurity 69
19094-56-5
|
US $0.00 / mg | 10mg | 0.98 | 5g | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- 2-Chloro-5-iodobenzoic acid
19094-56-5
- US $1000.00-400.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 2-Chloro-5-iodobenzoic acid
19094-56-5
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Dapagliflozin Impurity 69
19094-56-5
- US $0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
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