5-BROMO-2-IODOBENZALDEHYDE
- CAS No.
- 689291-89-2
- Chemical Name:
- 5-BROMO-2-IODOBENZALDEHYDE
- Synonyms
- 5-BROMO-2-IODOBENZALDEHYDE;Benzaldehyde, 5-bromo-2-iodo-
- CBNumber:
- CB8289359
- Molecular Formula:
- C7H4BrIO
- Molecular Weight:
- 310.91
- MDL Number:
- MFCD07779026
- MOL File:
- 689291-89-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-2-iodobenzaldehyde | OR40680 | 1g | $66 |
| 5-Bromo-2-iodobenzaldehyde | 2615-S-01 | 1g | $72 |
| 5-Bromo-2-iodobenzaldehyde | FB30961 | 1g | $120.8 |
| 5-Bromo-2-iodobenzaldehyde | FB30961 | 2g | $189 |
| 5-Bromo-2-iodobenzaldehyde | OR40680 | 5g | $195 |
| More product size | |||
| Melting point | 89-90 ºC |
|---|---|
| Boiling point | 312.2±27.0 °C(Predicted) |
| Density | 2.231 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | crystalline powder |
| color | Light gold (hint of orange) |
| InChI | InChI=1S/C7H4BrIO/c8-6-1-2-7(9)5(3-6)4-10/h1-4H |
| InChIKey | MOELYMOGQIDKNW-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC(Br)=CC=C1I |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H413 |
| Precautionary statements | P261-P273-P305+P351+P338 |
| HS Code | 2913000090 |
5-BROMO-2-IODOBENZALDEHYDE price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR40680 | 5-Bromo-2-iodobenzaldehyde | 689291-89-2 | 1g | $66 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2615-S-01 | 5-Bromo-2-iodobenzaldehyde | 689291-89-2 | 1g | $72 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB30961 | 5-Bromo-2-iodobenzaldehyde | 689291-89-2 | 1g | $120.8 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB30961 | 5-Bromo-2-iodobenzaldehyde | 689291-89-2 | 2g | $189 | 2021-12-16 | Buy |
| Apolloscientific | OR40680 | 5-Bromo-2-iodobenzaldehyde | 689291-89-2 | 5g | $195 | 2021-12-16 | Buy |
5-BROMO-2-IODOBENZALDEHYDE Chemical Properties,Uses,Production
Uses
5-Bromo-2-iodobenzaldehyde is a useful synthetic intermediate. It is used to prepare aza-fused polycyclic quinolines via copper-catalyzed cascade intermolecular condensation. It is also used in the synthesis of oxoindenopyrroles via copper-catalyzed tandem cycloaddition and coupling of iodoarylynones with isocyanides.
Synthesis
199786-58-8
689291-89-2
General procedure for the synthesis of 5-bromo-2-iodobenzaldehyde from (5-bromo-2-iodophenyl)methanol: Oxalyl chloride (1.99 mL, 23.04 mmol, 1.6 eq.) was dissolved in dichloromethane (DCM, 25 mL) under drying conditions and cooled to -70°C. In another vessel, DMSO (2.44 mL, 34.5 mmol, 2.4 eq.) was dissolved in DCM (25 mL) and similarly cooled to -65°C to -70°C. The DMSO solution was slowly added to the oxalyl chloride solution under nitrogen protection, keeping the temperature at -70 °C and stirring for 10 min. Subsequently, a solution of (5-bromo-2-iodophenyl)methanol (4.55 g, 14.4 mmol, 1.0 eq.) in DCM (100 mL) was added and the reaction mixture was continued to be stirred at -65 °C for 15 min. Next, triethylamine (10 mL, 72 mmol, 5.0 eq.) was added and the reaction mixture was gradually warmed to -10 °C and stirred at this temperature for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water (40 mL) and the mixture was gradually warmed to room temperature. The organic layer was separated and concentrated by evaporation to give 5-bromo-2-iodobenzaldehyde (4.2 g, 93% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.45 (d, J = 7.6 Hz, 1H), 7.81 (d, J = 11.6 Hz, 1H), 7.98 (d, J = 1.6 Hz, 1H), 9.97 (s, 1H).
References
[1] Organic Letters, 2008, vol. 10, # 14, p. 3001 - 3004
[2] Tetrahedron, 2011, vol. 67, # 1, p. 125 - 143
[3] Organic Letters, 2016, vol. 18, # 9, p. 2126 - 2129
[4] Patent: WO2018/15879, 2018, A1. Location in patent: Page/Page column 81-82
[5] Patent: US2004/92521, 2004, A1. Location in patent: Page/Page column 19-20; 46
5-BROMO-2-IODOBENZALDEHYDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29820 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4327 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
View Lastest Price from 5-BROMO-2-IODOBENZALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-14 | 5-BROMO-2-IODOBENZALDEHYDE
689291-89-2
|
US $1.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 5-BROMO-2-IODOBENZALDEHYDE
689291-89-2
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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