3-(Trifluoromethyl)cinnamic acid
- CAS No.
- 779-89-5
- Chemical Name:
- 3-(Trifluoromethyl)cinnamic acid
- Synonyms
- 3-[3-(TRIFLUOROMETHYL)PHENYL]PROP-2-ENOIC ACID;MTF-CNA;Cinacalcet-27;TIMTEC-BB SBB000553;RARECHEM BK HW 0018;CINMIC ACID IMPURITY;Cinacalcet Impurity 40;3-[3-(Trifluoromethyl)Pheny;m-(Trifluoromethyl)Cinnamic;3-rifluoromethyl)CinnamicAcid
- CBNumber:
- CB8295905
- Molecular Formula:
- C10H7F3O2
- Molecular Weight:
- 216.16
- MDL Number:
- MFCD00004393
- MOL File:
- 779-89-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-(Trifluoromethyl)cinnamic Acid >99.0%(GC)(T) | T1547 | 5g | $116 |
| 3-(Trifluoromethyl)cinnamic Acid >99.0%(GC)(T) | T1547 | 25g | $350 |
| 3-(Trifluoromethyl)cinnamic Acid | T791225 | 1g | $45 |
| 3-(Trifluoromethyl)cinnamic Acid 99% | JK954997 | 5g | $48 |
| 3-(Trifluoromethyl)cinnamic Acid 98% | PC7663 | 100g | $63 |
| More product size | |||
| Melting point | 135-137 °C(lit.) |
|---|---|
| Boiling point | 224°C (rough estimate) |
| Density | 1.3275 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.25±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| BRN | 1963372 |
| InChI | InChI=1S/C10H7F3O2/c11-10(12,13)8-3-1-2-7(6-8)4-5-9(14)15/h1-6H,(H,14,15) |
| InChIKey | KSBWHDDGWSYETA-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C=CC1=CC=CC(C(F)(F)F)=C1 |
| CAS DataBase Reference | 779-89-5(CAS DataBase Reference) |
| FDA UNII | P9LJ9ON37W |
| EPA Substance Registry System | 3-[3-(Trifluoromethyl)phenyl]acrylic acid (779-89-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-37/38 | |||||||||
| Safety Statements | 26-37/39-37 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-(Trifluoromethyl)cinnamic acid price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T1547 | 3-(Trifluoromethyl)cinnamic Acid >99.0%(GC)(T) | 779-89-5 | 5g | $116 | 2026-04-30 | Buy |
| TCI Chemical | T1547 | 3-(Trifluoromethyl)cinnamic Acid >99.0%(GC)(T) | 779-89-5 | 25g | $350 | 2026-04-30 | Buy |
| TRC | T791225 | 3-(Trifluoromethyl)cinnamic Acid | 779-89-5 | 1g | $45 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK954997 | 3-(Trifluoromethyl)cinnamic Acid 99% | 779-89-5 | 5g | $48 | 2021-12-16 | Buy |
| Apolloscientific | PC7663 | 3-(Trifluoromethyl)cinnamic Acid 98% | 779-89-5 | 100g | $63 | 2021-12-16 | Buy |
3-(Trifluoromethyl)cinnamic acid Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Had sedative hypnotic activity in mice, showing potent inhibition of spontaneous motility.
Uses
3-(Trifluoromethyl)cinnamic acid is used in the synthesis of cinacalcet. Cinacalcet is a drug for the control and treatment of secondary hyperparathyroidism (in the dialysis population), primary hyperparathyroidism where the patient may not be a candidate for surgical treatment, and for the treatment of calciphylaxis in patients with end-stage renal disease or in patients on dialysis.
Definition
ChEBI: (E)-3-(trifluoromethyl)cinnamic acid is a member of the class of (trifluoromethyl)benzenes consisting of trans-cinnamic acid having a trifluoromethyl substituent at the meta-position. It is a member of cinnamic acids, a member of styrenes and a member of (trifluoromethyl)benzenes. It is functionally related to a trans-cinnamic acid.
Synthesis
To a suspension of m-trifluoromethyl-α-bromohydrocinnamic acid, isopropanol (1.42 1) and benzyltriethylammonium chloride (10.85g), aqueous sodium hydroxide (340 ml, 56%) was added slowly. The temperature was raised to 55-60℃, stirred for 7 hours, and isopropanol was removed in vacuo. Water (500ml) was added to the reaction mass, stirred, cooled to 0℃, and acidified with hydrochloric acid (450ml). The solid was filtered, washed with water, and dried in vacuo at 5O℃ to afford 204g of 3-(Trifluoromethyl)cinnamic acid.
3-(Trifluoromethyl)cinnamic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yangzhou Qinyuan Pharmatech Co.,ltd | +86-18752526868 +86-18752526868 | jennysun@yzqyyykj.com | China | 80 | 58 |
| Shandong Jihui Chemical Co., Ltd. | +8615053042019 | sales@jihuichem.com | China | 34 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
Related articles
- The synthesis of 3-(Trifluoromethyl)cinnamic acid
- 3-(Trifluoromethyl)cinnamic acid is a critical intermediate of cinnalcet hydrochloride which is a calcimimetic agent developed....
- Oct 10，2025
View Lastest Price from 3-(Trifluoromethyl)cinnamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | 3-(Trifluoromethyl)cinnamic acid
779-89-5
|
US $999.00-666.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-04-21 | 3-(Trifluoromethyl)cinnamic acid
779-89-5
|
US $29.00 / g | 99.98% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-02-28 | 3-(Trifluoromethyl)cinnamic acid
779-89-5
|
US $0.00-0.00 / kg | 1kg | Purity: 99% | 50tons | Shandong Jihui Chemical Co., Ltd. |
-
- 3-(Trifluoromethyl)cinnamic acid
779-89-5
- US $999.00-666.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 3-(Trifluoromethyl)cinnamic acid
779-89-5
- US $29.00 / g
- 99.98%
- TargetMol Chemicals Inc.
-
- 3-(Trifluoromethyl)cinnamic acid
779-89-5
- US $0.00-0.00 / kg
- Purity: 99%
- Shandong Jihui Chemical Co., Ltd.
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