Guaiazulene
- CAS No.
- 489-84-9
- Chemical Name:
- Guaiazulene
- Synonyms
- Azulene, 1,4-dimethyl-7-(1-methylethyl)-;Azulol;Guaiazulenum;Azunol;Guiazulene;7-ISOPROPYL-1,4-DIMETHYLAZULENE;AZ-8;AZULON;uaiazuL;Cuteazul
- CBNumber:
- CB8298946
- Molecular Formula:
- C15H18
- Molecular Weight:
- 198.3
- MDL Number:
- MFCD00003811
- MOL File:
- 489-84-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Guaiazulene 99% | G11004 | 10g | $91.5 |
| Guaiazulene 99% | G11004 | 25g | $149 |
| Guaiazulene >99.0%(GC) | G0228 | 10g | $89 |
| Guaiazulene phyproof Reference Substance | PHL89697 | 100mg | $287 |
| Guaiazulene | 451501 | 2.5g | $403 |
| More product size | |||
| Melting point | 27-29 °C (lit.) |
|---|---|
| Boiling point | 153 °C/7 mmHg (lit.) |
| Density | 0.976 g/mL at 25 °C (lit.) |
| refractive index | 1.3166 (estimate) |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Sparingly) |
| form | Low Melting Crystalline Solid |
| color | Dark blue |
| Water Solubility | Soluble in alcohol, water, 0.1115 mg/L @ 25°C (est). |
| Merck | 14,4554 |
| BRN | 1365001 |
| Cosmetics Ingredients Functions |
ANTIMICROBIAL PERFUMING |
| InChI | 1S/C15H18/c1-10(2)13-7-5-11(3)14-8-6-12(4)15(14)9-13/h5-10H,1-4H3 |
| InChIKey | FWKQNCXZGNBPFD-UHFFFAOYSA-N |
| SMILES | CC(C)c1ccc(C)c2ccc(C)c2c1 |
| LogP | 5.590 (est) |
| CAS DataBase Reference | 489-84-9(CAS DataBase Reference) |
| FDA 21 CFR | 73.2180 |
| EWG's Food Scores | 1-4 |
| FDA UNII | 2OZ1K9JKQC |
| NIST Chemistry Reference | Azulene, 1,4-dimethyl-7-(1-methylethyl)-(489-84-9) |
| EPA Substance Registry System | Azulene, 1,4-dimethyl-7-(1-methylethyl)- (489-84-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-20/21/22 | |||||||||
| Safety Statements | 36/37/39-26-22-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CO4790000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2902190000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
Guaiazulene price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G11004 | Guaiazulene 99% | 489-84-9 | 10g | $91.5 | 2026-03-19 | Buy |
| Sigma-Aldrich | G11004 | Guaiazulene 99% | 489-84-9 | 25g | $149 | 2026-03-19 | Buy |
| TCI Chemical | G0228 | Guaiazulene >99.0%(GC) | 489-84-9 | 10g | $89 | 2026-03-19 | Buy |
| Sigma-Aldrich | PHL89697 | Guaiazulene phyproof Reference Substance | 489-84-9 | 100mg | $287 | 2026-03-19 | Buy |
| Usbiological | 451501 | Guaiazulene | 489-84-9 | 2.5g | $403 | 2021-12-16 | Buy |
Guaiazulene Chemical Properties,Uses,Production
Chemical Properties
DARK BLUE LOW MELTING CRYSTALLINE SOLID
Originator
AZ 8,Millet Roux
Uses
antioxidant, inhibits lipid peroxidation inhibitor, antiinflammatory, hepatoprotectant; LD50(rat) 1550 mg/kg po
Uses
Guaiazulene can be used as a starting material for the synthesis of:
- Azulene-based dye molecules such as 3-(7-isopropyl-1,4-dimethylazulen-3-yl)-2-cyanoacrylic acid and 5-(7-isopropyl-1,4-dimethylazulen-3-yl)-2-cyanopenta-2,4-dienoic acid.
- Stilbazulenyl nitrone, a second-generation azulenyl nitrone which can be used as a chain-breaking antioxidant.
- Bis-azulenyl based near-infrared fluorescence quencher.
Definition
ChEBI: Guaiazulene is a sesquiterpene. It derives from a hydride of a guaiane.
Manufacturing Process
10 kg a gum of Guacum officinale was heated with 3-4 kg of sulfur to 130°C.
The heating was slowly continued for 220°C under the nitrogen. The formed
water steam was removed with the nitrogen current. The temperature should
be higher 100°C in order to the water didnt fall into reaction mixture. H2S was
obtained simultaneously the dehydrogenation and removed with water steam.
Hydrogen sulfide was connected in an alkaline trap.
When a H2S discharge stopped, the temperature was decreased to 120°C and
the reaction mixture was distilled in vacuum 1-20 mm. The distillate had deep
blue color and contained 6-7 kg oil with 20% of 7-isopropyl-1,4-
dimethylazulene. It was dissolved in the 5-10 volumes of light petroleum,
shook with sodium hydroxide for removing the sulfur containing substaneces,
washed to neutral. Then petrolem layer was mixed with 10-15 L 62% H2SO4
for removing the by-products, the petroleum layer lost the blue color and the
desired substance was in sulphuric acid layer. The last one was shook with ice
and NaOH. As a result about 7% NaSO4 solution in sulfuric acid was obtained.
It was diluted and azulene gave an emulsion, which was extracted with 10 L
of petrolem and distilled. The 7-isopropyl-1,4-dimethylazulene is distilled at
167°-168°C/12 mm. Yield 10-15%.
Therapeutic Function
Antiinflammatory
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Purification Methods
It forms blue-violet plates from EtOH. Also redistil it in vacuo until distillate solidifies. UV has max at 284nm (log 4.6, heptane). The picrate has m 122o(EtOH). [Beilstein 5 III 1677, 5 IV 1751.]
Guaiazulene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Sinoway Industrial co., ltd. | +86-0592-5800732 +86-13806035118 | xie@china-sinoway.com | China | 1369 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| RongNa Biotechnology Co.,Ltd | +86-86-13583358881 +8618560316533 | Brad@rongnabiotech.com | China | 3364 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13815 | 58 |
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View Lastest Price from Guaiazulene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-17 | Guaiazulene
489-84-9
|
US $10.00 / ASSAYS | 1ASSAYS | 99% | 1 ton | RongNa Biotechnology Co.,Ltd | |
 |
2026-04-17 | Guaiazulene
489-84-9
|
US $0.00-0.00 / KG | 0.0001KG | 99.99% | 2000000T | Anhuyan (Hainan) Biotechnology Co., LTD | |
 |
2026-04-17 | Guaiazulene
489-84-9
|
US $500.00-300.00 / kg | 0.0010000000474974513kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD |
-
- Guaiazulene
489-84-9
- US $10.00 / ASSAYS
- 99%
- RongNa Biotechnology Co.,Ltd
-
- Guaiazulene
489-84-9
- US $0.00-0.00 / KG
- 99.99%
- Anhuyan (Hainan) Biotechnology Co., LTD
-
- Guaiazulene
489-84-9
- US $500.00-300.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
