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(R)-2-Flurbiprofen

(R)-2-Flurbiprofen Structure
(R)-2-Flurbiprofen structure
CAS No.
51543-40-9
Chemical Name:
(R)-2-Flurbiprofen
Synonyms
Tarenflurbil;(R)-FLURBIPROFEN;Flurizan;Furbiprofen;2-Flurbiprofen;E-7869;(R)-FL;MPC 7869;Flurbiprofene;l-Flurbiprofen
CBNumber:
CB8302496
Molecular Formula:
C15H13FO2
Molecular Weight:
244.26
MDL Number:
MFCD00869714
MOL File:
51543-40-9.mol
MSDS File:
SDS
Last updated:2025-08-20 16:56:25
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(R)-2-Flurbiprofen Properties

Melting point 110-113 °C(lit.)
Boiling point 376.2±30.0 °C(Predicted)
Density 1.199±0.06 g/cm3(Predicted)
storage temp. Store at RT
solubility DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml
form Crystalline Powder
pka 4.14±0.10(Predicted)
color White to off-white
InChI InChI=1/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/s3
InChIKey SYTBZMRGLBWNTM-JQHDBZEONA-N
SMILES C1(C=CC([C@@H](C)C(=O)O)=CC=1F)C1=CC=CC=C1 |&1:4,r|
NCI Dictionary of Cancer Terms R-flurbiprofen
FDA UNII 501W00OOWA
NCI Drug Dictionary Flurizan
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  26-36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
HS Code  29163900
NFPA 704
0
2 0

(R)-2-Flurbiprofen price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 70255 (R)-Flurbiprofen ≥99% 51543-40-9 100mg $32 2024-03-01 Buy
Cayman Chemical 70255 (R)-Flurbiprofen ≥99% 51543-40-9 1g $133 2024-03-01 Buy
Cayman Chemical 70255 (R)-Flurbiprofen ≥99% 51543-40-9 250mg $73 2024-03-01 Buy
Cayman Chemical 70255 (R)-Flurbiprofen ≥99% 51543-40-9 500mg $116 2024-03-01 Buy
TRC F598730 (R)-Flurbiprofen 51543-40-9 250mg $140 2021-12-16 Buy
Product number Packaging Price Buy
70255 100mg $32 Buy
70255 1g $133 Buy
70255 250mg $73 Buy
70255 500mg $116 Buy
F598730 250mg $140 Buy

(R)-2-Flurbiprofen Chemical Properties,Uses,Production

Description

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.

Uses

(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

Definition

ChEBI: (R)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (S)-flurbiprofen.

Biochem/physiol Actions

gamma secretase inhibitor; amyloid Abeta 42 lowering agent

in vivo

Effects of the early and late onset of treatment with Tarenflurbil ((R)-Flurbiprofen) are assessed in C57BL6/J mice that develop a non-remitting form of the disease, and in SJL mice that develop a relapsing-remitting (RR)-EAE. Tarenflurbil ((R)-Flurbiprofen) completely prevents the development of clinical EAE scores in C57BL6/J mice when the treatment is started within 3 days after immunization. This regimen is referred to as preventive treatment. The effect is dose-dependent, and the minimum daily dose for complete prevention is 5 mg/kg/day. Effects of Tarenflurbil ((R)-Flurbiprofen) are comparable to those of Fingolimod (FTY720, 0.5 mg/kg/day), which is used as the positive control. Tarenflurbil ((R)-Flurbiprofen) also significantly reduces clinical EAE scores in C57BL6/J mice when treatment is started shortly before onset of clinical manifestations, referred to as semi-therapeutic (10 mg/kg/day) and reduces clinical scores when the treatment is initiated after full development of the disease on day 13 (5 mg/g/day)[3].

References

[1] THOMAS L. KUKAR. Substrate-targeting γ-secretase modulators[J]. Nature, 2008, 453 7197: 925-929. DOI: 10.1038/nature07055
[2] IRMGARD TEGEDER. Inhibition of NF-KB and AP-1 activation by R- and S-flurbiprofen?,?[J]. FASEB Journal, 2001, 15 1: 2-4. DOI: 10.1096/fasebj.15.1.2
[3] EMILY J QUANN. The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells.[J]. Cancer research, 2007, 67 7: 3254-3262. DOI: 10.1158/0008-5472.can-06-3657
[4] KAREN D. B. SMITH  Robia G P  Richard Paylor. R-flurbiprofen improves axonal transport in the Tg2576 mouse model of Alzheimer’s Disease as determined by MEMRI[J]. Magnetic Resonance in Medicine, 2010, 65 5: 1423-1429. DOI: 10.1002/mrm.22733

(R)-2-Flurbiprofen Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-2-Flurbiprofen Suppliers

Global( 219)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8617732866630 abby@chuanghaibio.com China 8773 58
Hebei Mujin Biotechnology Co.,Ltd 		+8613288715578 sales@hbmojin.com China 12317 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +8618949832763 info@tnjchem.com China 2988 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8619521488211 info@longyupharma.com China 2557 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10242 58
Longyan Tianhua Biological Technology Co., Ltd 		0086 18039857276 18039857276 CHINA 2783 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58
Shanghai Longyu Biotechnology Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
Hubei Ipure Biology Co., Ltd 		58
Longyan Tianhua Biological Technology Co., Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from (R)-2-Flurbiprofen manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-2-Flurbiprofen pictures 2025-08-08 (R)-2-Flurbiprofen
51543-40-9
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
(R)-2-Flurbiprofen pictures 2025-06-24 (R)-2-Flurbiprofen
51543-40-9
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
(R)-2-Flurbiprofen pictures 2021-11-15 (R)-2-Flurbiprofen
51543-40-9
 US $90.00 / KG 10KG 99.9% 100tons Qiuxian Baitai New Material Co., LTD

(R)-2-Flurbiprofen Spectrum

(R)-2-Flurbiprofen(51543-40-9)1HNMR

51543-40-9((R)-2-Flurbiprofen)Related Search:

Kresoxim-methyl Methylparaben Ethyl 2-(Chlorosulfonyl)acetate Biphenyl (Trifluoromethyl)trimethylsilane
2-Fluorophenylacetic acid 2-Phenylisobutyric acid Phenylmethylsulfonyl fluoride α-Lipoic Acid 4-Biphenylacetic acid
Flurbiprofen 2-Methylbenzotrifluoride Bensulfuron methyl Methyl acrylate Trifluoromethanesulfonic anhydride
3-(Trifluoromethyl)benzaldehyde 3-（trifluoromethyl) Cinnamaldehyde Methyl

1of4

(R)-2-Fluoro-α-methyl-1,1'-biphenyl-4-acetic acid (R)-α-Methyl-2-fluoro-1,1'-biphenyl-4-acetic acid (R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid (Flurbiprofe [1,1'-Biphenyl]-4-aceticacid, 2-fluoro-a-Methyl-,(aR)- Flurizan MPC 7869 (R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid 97% (R)-Flurbiprofen, >=99% (R)-2-Flurbiprofenr (R)-2-FLUBIPROFEN (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID (R)-(-)-FLURBIPROFEN (R)-FLURBIPROFEN E-7869 (R)-2-fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic acid Flurbiprofene (R)-(-)-2-Fluoro-α-methyl-4-biphenylacetic acid (R)-2-Flurbiprofen Furbiprofen [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (R)- [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (αR)-　 l-Flurbiprofen (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID (FLURBIPROFEN) E7869,Tarenflurbil,MPC7869 (R)-2-Flurbiprofen, Tarenflurbil 2-Flurbiprofen Tarenflurbil (R)-2-(2-Fluoro-1,1'-biphenyl-4-yl)propionic acid (R)-Flurbiprofen (E7869 Flurbiprofen CRS (R)-FL Flurbiprofen (R)-Isomer (R)-(?)-2-Fluoro-α-methyl-4-biphenylacetic acid (R)-2-Flurbiprofen USP/EP/BP (2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic aci R- Flurbiprofen-d4 (R)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoic acid (-)-Flurbiprofen (R)-Flurbiprofen (Tarenflurbil), gamma-secretase inhibitor Tarenflurbil, 10 mM in DMSO (R)-(?)-2-Fluoro-α-methyl-4-biphenylacetic acid 51543-40-9 1543-40-9 Organic Building Blocks Chiral Building Blocks Asymmetric Synthesis Carboxylic Acids API Pharmaceutical ingredients