5-bromo-2,3-dihydro-3,3-dimethylinden-1-one
- CAS No.
- 67159-85-7
- Chemical Name:
- 5-bromo-2,3-dihydro-3,3-dimethylinden-1-one
- Synonyms
- 5-bromo-3,3-dimethyl-1-indanone;5-bromo-2,3-dihydro-3,3-dimethylinden-1-one;5-Bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one;5-Bromo-2,3-dihydro-3,3-dimethyl-1H-inden-1-one;1H-Inden-1-one, 5-bromo-2,3-dihydro-3,3-dimethyl-
- CBNumber:
- CB83038879
- Molecular Formula:
- C11H11BrO
- Molecular Weight:
- 239.11
- MDL Number:
- MFCD27927273
- MOL File:
- 67159-85-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P261-P305+P351+P338 |
5-bromo-2,3-dihydro-3,3-dimethylinden-1-one price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 307293 | 5-Bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one | 67159-85-7 | 250.00mg | $65 | 2026-05-19 | Buy |
| Matrix Scientific | 307293 | 5-Bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one | 67159-85-7 | 1.00g | $184 | 2026-05-19 | Buy |
| Matrix Scientific | 307293 | 5-Bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one | 67159-85-7 | 5.00g | $911 | 2026-05-19 | Buy |
| Synthonix | B54474 | 5-Bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one 95% | 67159-85-7 | 100mg | $60 | 2026-05-06 | Buy |
| Synthonix | B54474 | 5-Bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one 95% | 67159-85-7 | 1g | $200 | 2026-05-06 | Buy |
5-bromo-2,3-dihydro-3,3-dimethylinden-1-one Chemical Properties, Uses, Production
Chemical Properties
Colorless liquid
Synthesis
67159-88-0
67159-85-7
6-Bromo-1,1-dimethyl-2,3-dihydro-1H-indene (3.6 g, 16 mmol) was used as a raw material and dissolved in acetic acid (50 mL). Subsequently, an oxidizer solution prepared from CrO3 (9.6 g, 96.0 mmol) dissolved in 50% aqueous acetic acid (50 mL) was added to this solution. The reaction mixture was heated and stirred at 60 °C for 3 hours. Upon completion of the reaction, the reaction was quenched by addition of isopropanol (20 mL). The quenched reaction mixture was partitioned between EtOAc (200 mL) and 0.25 M NaOH aqueous solution (100 mL). The organic layer was separated and the aqueous phase was further extracted with EtOAc (2 × 100 mL). All organic phases were combined, washed with brine, dried over anhydrous Na2SO4, filtered and concentrated. Purification by rapid chromatography on silica gel (with 50% EtOAc/hexane as eluent) afforded the target product 5-bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one (2.91 g, 76% yield) as a white solid. The product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 7.65 (s, 1H), 7.47-7.58 (m, 2H), 2.58 (s, 2H), 1.42 (s, 6H); mass spectrum (EI) m/z = 240.1 [M + 1]+.
References
[1] Patent: EP2236500, 2010, A1. Location in patent: Page/Page column 39-40
[2] Patent: US2012/225857, 2012, A1. Location in patent: Page/Page column 24
[3] Patent: US2006/173183, 2006, A1. Location in patent: Page/Page column 123
5-bromo-2,3-dihydro-3,3-dimethylinden-1-one Preparation Products And Raw materials
5-bromo-2,3-dihydro-3,3-dimethylinden-1-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LABTER PHARMATECH(BEIJING) CO.,LTD | 010-56330744 18310155299 | sales@labter.com.cn | China | 19999 | 55 |
| ShangHai Wisacheam Pharmaceutical Co., Ltd. | 13817485796 | tim@wisacheampharm.com | China | 3698 | 58 |
| skychemical Co.Ltd | 021-20960837,QQ1332204249 | sales@skychemical.com | China | 3338 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Bejing Famous Pharmaceutical Technology Co., Ltd. | 010-80339217; 13331045123 | 2559355526@qq.com | China | 14180 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Labnetwork lnc. | +86-27-50766799 +86-18062016861 | contact@labnetwork.com | China | 19981 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
