Cuspin-1
- CAS No.
- 337932-29-3
- Chemical Name:
- Cuspin-1
- Synonyms
- Cuspin-1;Cuspin 1,Cuspin1;Cuspin-1 >=98% (HPLC);(5-Bromo-3-pyridinyl)(4-methylphenyl)methanone;Methanone, (5-bromo-3-pyridinyl)(4-methylphenyl)-
- CBNumber:
- CB83067543
- Molecular Formula:
- C13H10BrNO
- Molecular Weight:
- 276.1286
- MDL Number:
- MFCD00452965
- MOL File:
- 337932-29-3.mol
| Product description | Number | Pack Size | Price |
| Cuspin-1 ≥98% | 18526 | 5mg | $57 |
| Cuspin-1 ≥98% | 18526 | 10mg | $95 |
| Cuspin-1 ≥98% | 18526 | 25mg | $208 |
| Cuspin-1 ≥98% | 18526 | 50mg | $384 |
| Cuspin1 | C845005 | 10mg | $85 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
|
Cuspin-1 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18526 | Cuspin-1 ≥98% | 337932-29-3 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 18526 | Cuspin-1 ≥98% | 337932-29-3 | 10mg | $95 | 2024-03-01 | Buy |
| Cayman Chemical | 18526 | Cuspin-1 ≥98% | 337932-29-3 | 25mg | $208 | 2024-03-01 | Buy |
| Cayman Chemical | 18526 | Cuspin-1 ≥98% | 337932-29-3 | 50mg | $384 | 2024-03-01 | Buy |
| TRC | C845005 | Cuspin1 | 337932-29-3 | 10mg | $85 | 2021-12-16 | Buy |
Cuspin-1 Chemical Properties,Uses,Production
Description
The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.
Uses
Cuspin 1 is used in cuspin-1 characterization and regulation of SMN protein via Ras signaling in spinal muscular atropy.
References
[1] REKA R. LETSO. Small Molecule Screen Reveals Regulation of Survival Motor Neuron Protein Abundance by Ras Proteins[J]. ACS Chemical Biology, 2013, 8 5: 914-922. DOI: 10.1021/cb300374h
Cuspin-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Cuspin-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
