Methyl 1H-indazole-4-carboxylate
- CAS No.
- 192945-49-6
- Chemical Name:
- Methyl 1H-indazole-4-carboxylate
- Synonyms
- Methyl indazole-4-carboxy...;Methyl indazole-4-carboxylate;4-(Methoxycarbonyl)-1H-indazole;METHYL 1H-INDAZOLE-4-CARBOXYLATE;Methyl 1H-indazole-4-carboxylate;INDAZOLE-4-CARBOXYLIC ACID METHYL ESTER;4-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER;1H-Indazole-4-carboxylic acid, Methyl ester;1(2)H-Indazole-4-Carboxylic Acid Methyl Ester
- CBNumber:
- CB8308377
- Molecular Formula:
- C9H8N2O2
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD07371610
- MOL File:
- 192945-49-6.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P280-P301+P312 |
| WGK Germany | 3 |
| HS Code | 2933998090 |
Methyl 1H-indazole-4-carboxylate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 729744 | Methyl 1H-indazole-4-carboxylate 97% | 192945-49-6 | 1g | $97.5 | 2023-06-20 | Buy |
| TRC | M321298 | Methyl 1H-indazole-4-carboxylate | 192945-49-6 | 100mg | $60 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H23-1-12 | Methyl 1H-indazole-4-carboxylate 98% | 192945-49-6 | 5G | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 069833 | 1H-Indazole-4-carboxylic acid methyl ester 97% | 192945-49-6 | 500mg | $13 | 2021-12-16 | Buy |
| Matrix Scientific | 069833 | 1H-Indazole-4-carboxylic acid methyl ester 97% | 192945-49-6 | 1g | $19 | 2021-12-16 | Buy |
Methyl 1H-indazole-4-carboxylate Chemical Properties,Uses,Production
Synthesis
18583-89-6
192945-49-6
The general procedure for the synthesis of methyl indazole-4-carboxylate from methyl 3-amino-2-methylbenzoate was as follows: methyl 3-amino-2-methylbenzoate (0.3 g, 1.96 mmol) was dissolved in aqueous NaNO2 (0.62 g, 2 mmol), followed by the slow addition of dilute aqueous glacial acetic acid (7 mL, 3 mmol, the volume ratio of glacial acetic acid to water was 0.2:10). The reaction mixture was stirred at room temperature for 4-6 hours. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (EtOAc) and the organic layer was washed with deionized water (2 x 10 mL). The organic layer was dried over anhydrous sodium sulfate (Na2SO4), concentrated under reduced pressure and purified by column chromatography to give the yellow powdery product indazole-4-carboxylic acid methyl ester. The yield was 0.22 g in 69%; the melting point was 153-155 °C. The product was purified by column chromatography. The 1H NMR (400 MHz, CDCl3, TMS as internal standard, δ in ppm) data of the product were as follows: δ2.55 (s, 3H), 7.37 (t, 1H, J=14.32 Hz), 7.53 (s, 1H), 7.67 (d, 1H, J=8.12 Hz), 7.82 (d, 1H, J=8.16 Hz), 9.79 (s, 1H).
References
[1] Patent: US2012/130078, 2012, A1. Location in patent: Page/Page column 4-5
[2] Patent: EP2141150, 2010, A1. Location in patent: Page/Page column 48
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 1, p. 41 - 58
[4] Asian Journal of Chemistry, 2014, vol. 26, # 7, p. 1921 - 1930
[5] Patent: WO2009/108838, 2009, A1. Location in patent: Page/Page column 104
Methyl 1H-indazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8829 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9647 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
View Lastest Price from Methyl 1H-indazole-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-06 | 4-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER
192945-49-6
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 4-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER
192945-49-6
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
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