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(R)-(-)-3-Hydroxytetrahydrofuran

(R)-(-)-3-Hydroxytetrahydrofuran structure

CAS No.: 86087-24-3

Chemical Name:: (R)-(-)-3-Hydroxytetrahydrofuran

Synonyms: (R)-TETRAHYDROFURAN-3-OL;(3R)-Tetrahydrofuran-3-ol;(R)-3-HYDROXYTETRAHYDROFURAN;(3R)-oxolan-3-ol;Empagliflozin Impurity 67;(3R)-Tetrahydrofuran-3α-ol;Empagliflozin Impurity 149;3-FURANOL, TETRAHYDRO-, (R);(R)-(-)-TETRAHYDRO-3-FURANOL;3-Furanol, tetrahydro-,(3R)-

CBNumber:: CB8310051

Molecular Formula:: C4H8O2

Molecular Weight:: 88.11

MDL Number:: MFCD00067101

MOL File:: 86087-24-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:54:45

Product description	Number	Pack Size	Price
(R)-(?)-3-Hydroxytetrahydrofuran 98%	309753	1g	$36.75
(R)-3-Hydroxytetrahydrofuran >98.0%(GC)	H1332	1g	$63
(R)-3-Hydroxytetrahydrofuran >98.0%(GC)	H1332	5g	$214
(R)-(-)-3-Hydroxytetrahydrofuran	TRC-H957760-1G	1g	$105
(R)-TETRAHYDROFURAN-3-OL 97%	66692	5G	$38
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(R)-(-)-3-Hydroxytetrahydrofuran Properties

alpha	-18.5 º (c=2 MeOH)
Boiling point	181 °C (lit.)
Density	1.097 g/mL at 25 °C (lit.)
refractive index	n20/D 1.45(lit.)
Flash point	180 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Methanol (Slightly)
form	Liquid
pka	14.49±0.20(Predicted)
color	Clear colorless
Specific Gravity	1.097
optical activity	[α]20/D 18°, c = 2.4 in methanol
InChI	InChI=1S/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2/t4-/m1/s1
InChIKey	XDPCNPCKDGQBAN-SCSAIBSYSA-N
SMILES	O1CC[C@@H](O)C1
CAS DataBase Reference	86087-24-3(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

NA 1993 / PGIII

WGK Germany

HazardClass

CBL

HS Code

29321900

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Excepted Quantities

Non-Hazardous

NFPA 704

	2
2		0

(R)-(-)-3-Hydroxytetrahydrofuran price More Price(89)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	309753	(R)-(?)-3-Hydroxytetrahydrofuran 98%	86087-24-3	1g	$36.75	2026-04-30	Buy
TCI Chemical	H1332	(R)-3-Hydroxytetrahydrofuran >98.0%(GC)	86087-24-3	1g	$63	2026-04-30	Buy
TCI Chemical	H1332	(R)-3-Hydroxytetrahydrofuran >98.0%(GC)	86087-24-3	5g	$214	2026-04-30	Buy
TRC	TRC-H957760-1G	(R)-(-)-3-Hydroxytetrahydrofuran	86087-24-3	1g	$105	2026-06-03	Buy
AstaTech	66692	(R)-TETRAHYDROFURAN-3-OL 97%	86087-24-3	5G	$38	2026-04-30	Buy

Product number	Packaging	Price	Buy
309753	1g	$36.75	Buy
H1332	1g	$63	Buy
H1332	5g	$214	Buy
TRC-H957760-1G	1g	$105	Buy
66692	5G	$38	Buy

(R)-(-)-3-Hydroxytetrahydrofuran Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-(-)-3-Hydroxytetrahydrofuran is used as a chemical reactant in the synthesis of pharmaceutical agents. Empagliflozin is synthesized using this reactant

Uses

(R)-(-)-3-Hydroxytetrahydrofuran may be used as building block in the synthesis of potent HIV protease inhibitors.

Synthesis

125605-10-9

86087-24-3

Example 5 Preparation of (R)-3-hydroxytetrahydrofuran: 35 g (0.28 mol) of (R)-4-chloro-1,3-butanediol made in reference to Example 2 was dissolved in 70 mL of 0.5 N hydrochloric acid solution and the reaction was heated under reflux conditions for 2 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was neutralized with 50% aqueous sodium hydroxide solution, followed by evaporation under reduced pressure to remove water. To the residual crystals and oily mixture, 60 mL of methanol was added and mixed with thorough stirring. Insoluble crystals were removed by filtration and the filtrate was concentrated under reduced pressure. Finally, the concentrated residue was distilled under reduced pressure to give 16.6 g of (R)-(-)-3-hydroxytetrahydrofuran in the form of colorless liquid (purity: 99.1%; yield: 67%). Its rotundity was determined as [α]D23 = -15.91° (c = 2.45, methanol).

References

[1] Patent: US5780649, 1998, A
[2] Patent: WO2008/93955, 2008, A1. Location in patent: Paragraph 65-66
[3] Patent: WO2016/21192, 2016, A1. Location in patent: Paragraph 0085

(R)-(-)-3-Hydroxytetrahydrofuran synthesis

Synthesis of (R)-(-)-3-Hydroxytetrahydrofuran from (R)-(+)-1,2,4-BUTANETRIOL

(R)-(-)-3-Hydroxytetrahydrofuran Preparation Products And Raw materials

Raw materials

3-Furanol, tetrahydro-, 3-acetate Dihydrofuran-3(2H)-one 3-Hydroxytetrahydrofuran (R)-4-CHLORO-1,3-BUTANEDIOL (R)-(+)-1,2,4-BUTANETRIOL

but-3-en-1-yl 4-methylbenzene-1-sulfonate (S)-1,2,4-Butanetriol 2,3-Dihydrofuran n-Butane Hydrochloric acid

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Preparation Products

Furan, tetrahydro-3-iodo-, (3S)- (S)-3-P-MESYLOXYTETRAHYDROFURAN

(R)-(-)-3-Hydroxytetrahydrofuran Suppliers

Global( 389)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	505	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-17732866630	mina@chuanghaibio.com	China	18126	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	13343047651	admin@zlchemi.com	China	3692	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14026	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Klong Industrial Co., Ltd	0086-519-68231162	info@klongchem.com	CHINA	131	58

Supplier	Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Klong Industrial Co., Ltd	58

View Lastest Price from (R)-(-)-3-Hydroxytetrahydrofuran manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-30	(R)-(-)-3-Hydroxytetrahydrofuran 86087-24-3	1KG	99% GC	100kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-02-02	(R)-(-)-3-Hydroxytetrahydrofuran 86087-24-3	1g	99%	2000tons	Shaanxi Dideu Medichem Co. Ltd
2025-06-27	(R)-(-)-3-Hydroxytetrahydrofuran 86087-24-3	1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

(R)-(-)-3-Hydroxytetrahydrofuran
86087-24-3
$0.00
99% GC
WUHAN FORTUNA CHEMICAL CO., LTD

(R)-(-)-3-Hydroxytetrahydrofuran
86087-24-3
99%
Shaanxi Dideu Medichem Co. Ltd

(R)-(-)-3-Hydroxytetrahydrofuran
86087-24-3
99%
Hebei Chuanghai Biotechnology Co., Ltd

(R)-(-)-3-Hydroxytetrahydrofuran Spectrum

(R)-(-)-3-Hydroxytetrahydrofuran(86087-24-3)¹HNMR (R)-(-)-3-Hydroxytetrahydrofuran(86087-24-3)IR (R)-(-)-3-Hydroxytetrahydrofuran(86087-24-3)FT-IR

86087-24-3((R)-(-)-3-Hydroxytetrahydrofuran)Related Search:

Tetrahydrofuran 2-Methyltetrahydrofuran 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Acetoxy Empagliflozin (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

(R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran (3R,4S,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)-2-methoxyoxane-3,4,5-triol EMpagliflozin iMpurity 10 Butanoic acid, 4-chloro-3-hydroxy-, (3S)- Methanone, (5-chloro-2-iodophenyl)(2-fluorophenyl)-

(5-bromo-2-chlorophenyl)(4-fluorophenyl)methanone 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)benzyl]benzene Empagliflozin Impurity 32 4-(pyridine-2-yl) pyrimidin-2-amine (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

(S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone EMpagliflozin iMpurity 13 Empagliflozin Impurity

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(R)-(-)-TETRAHYDRO-3-FURANOL (R)-(-)-3-HYDROXYTETRAHYDROFURAN (R)-3-HYDROXYTETRAHYDROFURAN (R)-(-)-3-HYDROXYTETRAHYDROFURANE 3-FURANOL, TETRAHYDRO-, (R) (3R)-Tetrahydrofuran-3α-ol (R)-(-)-3-Hydoxy tetahydrotetrahydrofuran (3R)-3-Hydroxytetrahydrofuran 3-Furanol, tetrahydro-,(3R)- (3R)-oxolan-3-ol Empagliflozin Impurity 67 (R)-3-hydroxytetyrahydrofurane (R)-(-)-3-Hydroxytetrahydrofur (R)-(-)-3-Hydroxytetrahydrofuran 98% (R)-Tetrahydrofuran-3-ol(Rotation(-)) (R)-3-Hydroxytetrahydrofuran> Empagliflozin Impurity 149 (-)-3-Hydroxytetrahydrofuran (R)-(-)-3-Hydroxytetrahydrof (R)-(?)-3-Hydroxytetrahydrofuran (3R)-Tetrahydrofuran-3-ol (R)-TETRAHYDROFURAN-3-OL 86087-24-3 6087-24-3 Asymmetric Synthesis Chiral Building Blocks Furans Heterocyclic Building Blocks Furans Building Blocks for HIV Protease InhibitorsChiral Building Blocks Cell Signaling Enzymes Heterocyclic Building Blocks HIV Protease Reagents&Envelope Proteins Alcohols, Hydroxy Esters and Derivatives Chiral Compounds chiral Tetrahydrofuran Series ADVANCED INT.