ACETAZOLAMIDE SODIUM
- CAS No.
- 1424-27-7
- Chemical Name:
- ACETAZOLAMIDE SODIUM
- Synonyms
- diamoxsodium;SODIUMACETAZOLAMIDE;ACETAZOLAMIDE SODIUM;acetazolamidesodiumsalt;n-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt;n-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt
- CBNumber:
- CB8313562
- Molecular Formula:
- C4H7N4NaO3S2
- Molecular Weight:
- 246.23
- MDL Number:
- MFCD01671159
- MOL File:
- 1424-27-7.mol
| storage temp. | 4°C, away from moisture |
|---|---|
| solubility | DMSO : 100 mg/mL (407.76 mM; Need ultrasonic) |
| form | Solid |
| color | Powder fine white |
| FDA UNII | 429ZT169UH |
| NCI Drug Dictionary | acetazolamide sodium |
ACETAZOLAMIDE SODIUM Chemical Properties,Uses,Production
Uses
Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities[1][4][5][6].
Definition
ChEBI: Acetazolamide sodium is an organic sodium salt. It contains an acetazolamide and an acetazolamide(1-).
brand name
Diamox (Duramed).
Safety Profile
ACETAZOLAMIDE SODIUM SALT ?? SODIUMACETAZOLAMIDE
in vivo
Acetazolamide (40 mg/kg) significantly potentiates the inhibitory effect of MS-275 on tumorigenesis in neuroblastoma (NB) SH-SY5Y xenografts[3].
?
Acetazolamide (40 mg/kg) and/or MS-275 treatment reduce expression of HIF1-α and CAIX in NB SH-SY5Y xenograft[3].
?
Acetazolamide (40 mg/kg), MS-275 and Acetazolamide+MS-275 reduce expression of mitotic and proliferative markers in NB SH-SY5Y xenografts[3].?
Acetazolamide (50 mg/kg; PO, for 3 days) significantly reduces the gonococcal load in the vagina of infected mice by 90%[6].
IC 50
CA Ⅸ
References
[1] Bayat Mokhtari R, et al. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 Feb 24;17(1):156. DOI:10.1186/s12885-017-3126-7
[2] Hou Z, et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26;132:1-10. DOI:10.1016/j.ejmech.2017.03.023
[3] Gao H, et al. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncol Lett. 2018 Jun;15(6):9299-9306. DOI:10.3892/ol.2018.8529
[4] Kassamali R, et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8. DOI:10.1097/CRD.0b013e31822b4939
[5] Jabeen E, et al. Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. J Photochem Photobiol B. 2013 Aug 5;125:155-63. DOI:10.1016/j.jphotobiol.2013.06.002
[6] Abutaleb NS, et al. In vivo efficacy of acetazolamide in a mouse model of Neisseria gonorrhoeae infection. Microb Pathog. 2022 Mar;164:105454. DOI:10.1016/j.micpath.2022.105454
ACETAZOLAMIDE SODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
ACETAZOLAMIDE SODIUM Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32431 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15146 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988968278 | YN_research@163.com | China | 3002 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5003 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
| Hubei YoungXin Pharmaceutical Tech Co.,Ltd. | 0714-3999001 18696290611 | 3003339751@qq.com | China | 8443 | 58 |
View Lastest Price from ACETAZOLAMIDE SODIUM manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-18 | Acetazolamide sodium
1424-27-7
|
US $40.00 / mg | 99.87% | 10g | TargetMol Chemicals Inc. |
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- Acetazolamide sodium
1424-27-7
- US $40.00 / mg
- 99.87%
- TargetMol Chemicals Inc.
