R162
- CAS No.
- 64302-87-0
- Chemical Name:
- R162
- Synonyms
- R162, >98%;R162;R-162;R 162;R162, 10 mM in DMSO;GDH1 Inhibitor, R162;2-ALLYL-1-HYDROXY-ANTHRAQUINONE;R162,inhibit,R-162,Inhibitor,R 162;2-Allyl-1-hydroxy-9,10-anthraquinone;2-allyl-1-hydroxyanthracene-9,10-dione;9,10-Anthracenedione, 1-hydroxy-2-(2-propenyl)-;9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)-
- CBNumber:
- CB83334050
- Molecular Formula:
- C17H12O3
- Molecular Weight:
- 264.28
- MDL Number:
- MFCD00666806
- MOL File:
- 64302-87-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| GDH1 Inhibitor, R162 | 5.38098 | 25 mg | $221 |
| R162 ≥98% | 30922 | 5mg | $57 |
| R162 ≥98% | 30922 | 10mg | $102 |
| R162 ≥98% | 30922 | 25mg | $209 |
| R162 ≥98% | 30922 | 50mg | $363 |
| More product size | |||
| Melting point | 120-120.5 °C(Solv: acetone (67-64-1)) |
|---|---|
| Boiling point | 459.0±34.0 °C(Predicted) |
| Density | 1.308±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml or in Ethanol (up to 5 mg/ml) |
| form | solid |
| pka | 7.43±0.20(Predicted) |
| color | Orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
R162 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.38098 | GDH1 Inhibitor, R162 | 64302-87-0 | 25 mg | $221 | 2026-04-30 | Buy |
| Cayman Chemical | 30922 | R162 ≥98% | 64302-87-0 | 5mg | $57 | 2026-04-30 | Buy |
| Cayman Chemical | 30922 | R162 ≥98% | 64302-87-0 | 10mg | $102 | 2026-04-30 | Buy |
| Cayman Chemical | 30922 | R162 ≥98% | 64302-87-0 | 25mg | $209 | 2026-04-30 | Buy |
| Cayman Chemical | 30922 | R162 ≥98% | 64302-87-0 | 50mg | $363 | 2026-04-30 | Buy |
R162 Chemical Properties,Uses,Production
Description
R162 (64302-87-0) is a selective inhibitor of glutamate dehydrogenase 1 (GDH1), a commonly upregulated enzyme in human cancers (Ki= 28.6 μM). It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. R162 treatment leads to decreased fumarate levels, lower glutathione peroxidase activity, increased ROS levels and reduced cell proliferation in H1299 and MDA-MB231 cells. R162 sensitizes LKB-1 deficient tumor cells to anoikis induction. R162 treatment (at 20 mg/kg/day) significantly attenuates metastatic potential in a xenograft mouse model.2 GDH1 is a promising antimetastasis target and R162 is a useful tool for proof of principal studies.
Uses
R162 is a glutamate dehydrogenase 1 inhibitor for the treatment of cancer. A useful bioactive chemical compound.
Definition
ChEBI: 2-allyl-1-hydroxy-9,10-anthraquinone is a monohydroxyanthraquinone that is 9,10-anthraquinone in which the hydrogens at positions 1 and 2 are replaced by a hydroxy and an allyl group, respectively. It has a role as an EC 1.4.1.3 {glutamate dehydrogenase [NAD(P)(+)]} inhibitor.
in vivo
R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice[1].
References
[1] LINGTAO JIN. Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.[J]. Cancer Cell, 2015, 27 2: 257-270. DOI:10.1016/j.ccell.2014.12.006
[2] LINGTAO JIN. The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.[J]. Molecular Cell, 2018, 69 1: 87-99.e7. DOI:10.1016/j.molcel.2017.11.025
R162 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9951 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301593;18013301590 | njduly@126.com | China | 3293 | 55 |
