s38093
- CAS No.
- 1222097-72-4
- Chemical Name:
- s38093
- Synonyms
- s38093;S38093 HCl;S 38093 HydrochL;S 38093 Hydrochloride;S 38093 HCl, 10 mM in DMSO;S 38093; S38093; S-38093; S38093 HCL;4-(3-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)benzamide hydrochloride
- CBNumber:
- CB83350593
- Molecular Formula:
- C17H25ClN2O2
- Molecular Weight:
- 324.85
- MDL Number:
- MFCD31729284
- MOL File:
- 1222097-72-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
s38093 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XYB09772 | S38093 HCl | 1222097-72-4 | 50mg | $828.5 | 2026-06-05 | Buy |
| Biosynth | XYB09772 | S38093 HCl | 1222097-72-4 | 100mg | $1325 | 2026-06-05 | Buy |
| Biorbyt Ltd | orb1303175 | S 38093 HCl 99.16%(Mayvarybetweenbatches) | 1222097-72-4 | 1mg | $80 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1303175 | S 38093 HCl 99.16%(Mayvarybetweenbatches) | 1222097-72-4 | 1mlx10mM(inDMSO) | $110 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1303175 | S 38093 HCl 99.16%(Mayvarybetweenbatches) | 1222097-72-4 | 5mg | $110 | 2026-05-06 | Buy |
s38093 Chemical Properties, Uses, Production
Description
S38093 is an inverse agonist at histamine H3 receptors. S 38093 displays a moderate affinity for rat, mouse and human H3 receptors (Ki=8.8, 1.44 and 1.2μM, respectively) with no affinity for other histaminergic receptors. In cellular models, the compound was able to antagonize mice H3 receptors (KB=0.65μM) and to suppress cAMP decrease induced by an H3 agonist via human H3 receptors (KB=0.11μM).
Uses
S 38093 hydrochloride is a brain-penetrant, orally active antagonist of H3 receptor, with Kis of 8.8, 1.44 and 1.2 μM for rat, mouse and human H3 receptors, respectively.
in vivo
S 38093 (0.3 and 3mg/kg/d p.o., 28 days) significantly increases proliferation of progenitors in the DG of hippocampus in young adult mice. S 38093 (0.3mg/kg/d) treatment significantly increases the number of DCX+ cells with tertiary dendrites. S 38093 (0.3, 1 and/or 3mg/kg) significantly increases cell proliferation, survival, and maturation in the DG of hippocampus in aged mice relative to vehicle. S 38093 (3mg/kg/d p.o., 28 days) increases cell proliferation and has a strong effect on cell survival, also increases the dendritic intersections in both genotypes (one-way ANOVA with repeated measure, p<0.01), with a significant effect from 50 to 80 in APPSWETG mice only. In aged mice, chronic administration of S 38093 (1 and/or 3mg/kg/day p.o., 28 days) reverses this age-dependent decrease in BDNF-IX, BDNF-IV and BDNF-I transcripts. In addition, S 38093 at three tested doses (0.3, 1 and 3mg/kg/d) increases VEGF transcripts compared to vehicle-aged group[1]. In mice, S 38093 significantly increases ex vivo N-tele-Methylhistamine cerebral levels from 3 mg/kg p.o. and antagonized R-α-Methylhistamine-induced dipsogenia from 10 mg/kg i.p[2].
References
[1] Guilloux JP, et al. S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci Rep. 2017 Feb 20;7:42946. DOI:10.1038/srep42946
[2] Sors A, et al. Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol. 2017 May 15;803:11-23 DOI:10.1016/j.ejphar.2017.03.013
s38093 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1838 | 58 | |
| Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1883 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
View Latest Price from s38093 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-08 | S 38093 HCl
1222097-72-4
|
$41.00-106.00 | 99.16% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-24 | s38093
1222097-72-4
|
$1.00 | 1g | 99% | 20kg | Career Henan Chemical Co |
-
- S 38093 HCl
1222097-72-4
- $41.00-106.00
- 99.16%
- TargetMol Chemicals Inc.
-
- s38093
1222097-72-4
- $1.00
- 99%
- Career Henan Chemical Co
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