2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate
- CAS No.
- 1224964-36-6
- Chemical Name:
- 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate
- Synonyms
- XL-784;XL 784,XL784;2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate
- CBNumber:
- CB83361487
- Molecular Formula:
- C21H22ClF2N3O8S
- Molecular Weight:
- 549.9294864
- MDL Number:
- MFCD30532589
- MOL File:
- 1224964-36-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| XL-784 | ZYB96436 | 5mg | $1067.3 |
| XL-784 | ZYB96436 | 10mg | $1477.8 |
| XL-784 | ZYB96436 | 25mg | $2141.75 |
| XL-784 98.25% | CS-0015584 | 5mg | $379 |
| XL-784 98.25% | CS-0015584 | 10mg | $596 |
2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate Properties
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO: ≥ 110 mg/mL (200.39 mM) |
| form | Solid |
| color | White to off-white |
| FDA UNII | 70N8WTD318 |
2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | ZYB96436 | XL-784 | 1224964-36-6 | 5mg | $1067.3 | 2026-06-05 | Buy |
| Biosynth | ZYB96436 | XL-784 | 1224964-36-6 | 10mg | $1477.8 | 2026-06-05 | Buy |
| Biosynth | ZYB96436 | XL-784 | 1224964-36-6 | 25mg | $2141.75 | 2026-06-05 | Buy |
| ChemScene | CS-0015584 | XL-784 98.25% | 1224964-36-6 | 5mg | $379 | 2026-06-04 | Buy |
| ChemScene | CS-0015584 | XL-784 98.25% | 1224964-36-6 | 10mg | $596 | 2026-06-04 | Buy |
2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate Chemical Properties,Uses,Production
Uses
XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, respectively.
in vivo
All mice tolerate the treatments similarly. Control mice all developed aneurysms with a mean %△AD of 158.5%±4.3%. Treatment with all doses of XL-784 and doxycycline are effective in inhibiting aortic dilatation. There is a clear dose-response relationship between XL-784 and reductions in aortic dilatation at harvest (50 mg/kg 140.4% ±3.2%; 125 mg/kg 129.3% ±5.1%; 250 mg/kg 119.2%±3.5%; all Ps<0.01 compared to control). This continues with the higher doses (375 mg/kg 88.6%±4.4%; 500 mg/kg 76.0%±3.5%). The highest 2 doses of XL-784 tested are more effective than doxycycline (112.2%±2.0%, P<0.05) in inhibiting maximal dilatation of the aorta after elastase perfusion[2].
IC 50
MMP-2: 0.81 nM (IC50); MMP13: 0.56 nM (IC50); MMP-8: 10.8 nM (IC50); MMP-9: 18 nM (IC50); MMP-3: 120 nM (IC50); MMP-1: 1900 nM (IC50)
References
[1] Williams JM, et al. Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy. Am J Physiol Renal Physiol. 2011 Apr;300(4):F983-98. DOI:10.1152/ajprenal.00262.2010
[2] Ennis T, et al. Effect of novel limited-spectrum MMP inhibitor XL784 in abdominal aortic aneurysms. J Cardiovasc Pharmacol Ther. 2012 Dec;17(4):417-26. DOI:10.1177/1074248412455695
2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9333 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Suzhou Chukai Pharma Tech Co.,Ltd | +86-15151706780; +8615062531973 | 2279973922@qq.com | China | 404 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| Suzhou Chukai PharmaTech | 0512-88812066 15062531973; | wenlongfcb@qq.com | China | 110 | 62 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10336 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
