CH-275
- CAS No.
- 174688-78-9
- Chemical Name:
- CH-275
- Synonyms
- CH-275;CYS-LYS-PHE-PHE-D-TRP-IAMP-THR-PHE-THR-SER-CYS;[DES-ALA1, DES-GLY2, DES-ASN5, D-TRP8, IAMP9]SOMATOSTATIN-14;Cys-Lys-Phe-Phe-D-Trp-IAMp-Thr-Phe-Thr-Ser-Cys (Disulfide bridge Cys3-Cys14);CKFF-{d-Trp}-XTFTSC (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe);L-Cysteine, L-cysteinyl-L-lysyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-4-[[(1-methylethyl)amino]methyl]-L-phenylalanyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-, cyclic (1→11)-disulfide
- CBNumber:
- CB8347170
- Molecular Formula:
- C74H96N14O15S2
- Molecular Weight:
- 1485.79
- MDL Number:
- MFCD22683792
- MOL File:
- 174688-78-9.mol
| Product description | Number | Pack Size | Price |
| CH275 | 2454 | 500U | $292 |
| CH275 | B5307 | 500ug | $423 |
| CH-275 95.00% | INB0001458 | 5MG | $505.26 |
| Boiling point | 1732.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.235±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| form | Powder |
| pka | 2.93±0.70(Predicted) |
| color | White to off-white |
| Water Solubility | Soluble to 0.30 mg/ml in water |
| Sequence | Cys-Lys-Phe-Phe-{d-Trp}-Phe-Thr-Phe-Thr-Ser-Cys (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe) |
CH-275 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2454 | CH275 | 174688-78-9 | 500U | $292 | 2021-12-16 | Buy |
| ApexBio Technology | B5307 | CH275 | 174688-78-9 | 500ug | $423 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001458 | CH-275 95.00% | 174688-78-9 | 5MG | $505.26 | 2021-12-16 | Buy |
CH-275 Chemical Properties,Uses,Production
Uses
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM[1]. CH 275 acts as a potent and selective sst1?agonist (IC50=30.9 nM) and also displays?IC50?values of 345 nM, >1?μM, >10?μM, >10?μM for human sst3, sst4, sst2?and sst5,?respectively[2]. CH 275 can be used for the research of alzheimer’s disease[3].
in vivo
CH275 (osmotic pump administration; 56 μM; two weeks) decreases the?level of neprilysin/SRIF in the?App?knock-in mice[3].CH275 directly injects into the Lacunosum molecular layer (Lmol) layer of 2-month-old AppNL-G-F mice for four months. AppNL-G-F mice begin to exhibit Aβ plaques at two months of age, but CH275 leads to robustly increased the expression of neprilysin in hippocampus which is paralleled by a clear reduction in Aβ plaque load in the same region, and without causing any toxic side effects[3].
IC 50
SSTR1
References
[1] L Chen, et al. Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem Biophys Res Commun. 1999 May 19;258(3):689-94. DOI:10.1006/bbrc.1999.0699
[2] J E Rivier, et al. Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J Med Chem. 2001 Jun 21;44(13):2238-46. DOI:10.1021/jm010037+
[3] Per?Nilsson,?et al. Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid β-degrading enzyme, in brain.
CH-275 Preparation Products And Raw materials
Raw materials
Preparation Products
CH-275 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13913916777; | info@chemlin.com.cn | China | 15778 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9497 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4802 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7408 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2395 | 58 |
| Hangzhou Go Top Peptide Biotech | 15397062932 | sales1@gotopbio.com | China | 3059 | 58 |
