GINKGETIN
- CAS No.
- 481-46-9
- Chemical Name:
- GINKGETIN
- Synonyms
- GINKGETIN;ginkgotin;Ginkgetin-RM;Ginkgetin, >98%;GINKGETIN USP/EP/BP;Ginkgetin, 10 mM in DMSO;GINKGETIN(RG)(PLEASE CALL);Ginkgetin, 98%, from Ginkgo biloba L.;4',5,5'',7-Tetrahydroxy-4''',7''-dimethoxy-8,3'''-biflavone;5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)chromen-4-one
- CBNumber:
- CB8350301
- Molecular Formula:
- C32H22O10
- Molecular Weight:
- 566.51
- MDL Number:
- MFCD09970948
- MOL File:
- 481-46-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ginkgetin ≥98% | 25103 | 1mg | $40 |
| Ginkgetin ≥98% | 25103 | 5mg | $160 |
| Ginkgetin ≥98% | 25103 | 10mg | $263 |
| Ginkgetin ≥98% | 25103 | 1mg | $36 |
| Ginkgetin ≥98% | 25103 | 5mg | $145 |
| More product size | |||
| Melting point | 297 °C(Solv: acetone (67-64-1)) |
|---|---|
| Boiling point | 863.7±65.0 °C(Predicted) |
| Density | 1.506±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:64.0(Max Conc. mg/mL);112.97(Max Conc. mM) DMSO:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.21(Max Conc. mM) |
| pka | 6.18±0.40(Predicted) |
| form | powder |
| color | Light yellow |
| InChIKey | AIFCFBUSLAEIBR-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(O)C=C2)OC2=C(C3=CC(C4OC5=CC(OC)=CC(O)=C5C(=O)C=4)=CC=C3OC)C(O)=CC(O)=C2C(=O)C=1 |
| LogP | 4.450 (est) |
| FDA UNII | HY5EZW8269 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
GINKGETIN price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25103 | Ginkgetin ≥98% | 481-46-9 | 1mg | $40 | 2026-04-30 | Buy |
| Cayman Chemical | 25103 | Ginkgetin ≥98% | 481-46-9 | 5mg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 25103 | Ginkgetin ≥98% | 481-46-9 | 10mg | $263 | 2026-04-30 | Buy |
| Cayman Chemical | 25103 | Ginkgetin ≥98% | 481-46-9 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 25103 | Ginkgetin ≥98% | 481-46-9 | 5mg | $145 | 2024-03-01 | Buy |
GINKGETIN Chemical Properties,Uses,Production
Chemical Properties
It is soluble in organic solvents such as methanol, ethanol, and DMSO, and is derived from Ginkgo biloba.
Uses
Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ[1][2][3][4][5].
Definition
ChEBI: A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxyge ase 2.
in vivo
Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway[4].
Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice[5].
| Animal Model: | Male Sprague-Dawley rats (200-220 g)[4] |
| Dosage: | 25, 50, 100 mg/kg |
| Administration: | I.p. 2 hours after the onset of ischemia |
| Result: | Reduced the neurological decit score. Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα. Decreased the expressions of ICAM-1, COX-2, and iNOS. Downregulated downstream inammatory factor PGE2 and TNF-α expression. Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression. |
References
[1] Hu WH, et, al. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 2019 Nov 20;11(12):1828. DOI:10.3390/cancers11121828
[2] Ye ZN, et, al. Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. Nat Prod Bioprospect. 2015 Mar 29;5(2):91-97. DOI:10.1007/s13659-015-0056-4
[3] Xiong M, et, al. Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9. Oncol Rep. 2016 Feb;35(2):1034-40. DOI:10.3892/or.2015.4427
[4] Li Q, et, al. Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Biosci Biotechnol Biochem. 2019 Apr;83(4):675-683. DOI:10.1080/09168451.2018.1553608
[5] Lou J, et, al. Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget. 2017 Oct 16;8(54):93131-93148. DOI:10.18632/oncotarget.21862
GINKGETIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1001 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 | CHINA | 964 | 58 | |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
View Lastest Price from GINKGETIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | Ginkgetin
481-46-9
|
US $98.00 / mg | 99.78% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Ginkgetin
481-46-9
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2022-02-25 | GINKGETIN
481-46-9
|
US $10.00 / KG | 1KG | 99% | 5000kg/month | Shanxi Naipu Import and Export Co.,Ltd |
