1,1'-(Azodicarbonyl)-dipiperidine
- CAS No.
- 10465-81-3
- Chemical Name:
- 1,1'-(Azodicarbonyl)-dipiperidine
- Synonyms
- ADDP;Diazene-1,2-diylbis(piperidin-1-ylMethanone);sr4077;NSC 356027;Azodicarboxylic;1,1'-(Azodicarbo;1,1'-(Azodicarbonyl);Diphenylpiperidylcarboxylate;AZODICARBOXYLIC DIPIPERIDIDE;1,1'-(azodicarbonyl)piperidine
- CBNumber:
- CB8352693
- Molecular Formula:
- C12H20N4O2
- Molecular Weight:
- 252.31
- MDL Number:
- MFCD00010111
- MOL File:
- 10465-81-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1,1′-(Azodicarbonyl)dipiperidine 99% | 255920 | 5g | $109 |
| 1,1′-(Azodicarbonyl)dipiperidine 99% | 255920 | 25g | $246 |
| 1,1'-(Azodicarbonyl)dipiperidine >98.0%(N) | A1051 | 5g | $78 |
| 1,1'-(Azodicarbonyl)dipiperidine >98.0%(N) | A1051 | 25g | $309 |
| 1,1''-(Azodicarbonyl)dipiperidine | 30486 | 1g | $32 |
| More product size | |||
| Melting point | 132-136 °C(lit.) |
|---|---|
| Boiling point | 366.4±25.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), insol petroleum ether; sol ethanol, ether, THF |
| pka | -0+-.0.20(Predicted) |
| form | solid |
| color | yellow |
| Water Solubility | Slightly soluble in water. |
| BRN | 261917 |
| InChI | InChI=1S/C12H20N4O2/c17-11(15-7-3-1-4-8-15)13-14-12(18)16-9-5-2-6-10-16/h1-10H2 |
| InChIKey | OQJBFFCUFALWQL-UHFFFAOYSA-N |
| SMILES | N(C(N1CCCCC1)=O)=NC(N1CCCCC1)=O |
| CAS DataBase Reference | 10465-81-3(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3234 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | No | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1,1'-(Azodicarbonyl)-dipiperidine price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 255920 | 1,1′-(Azodicarbonyl)dipiperidine 99% | 10465-81-3 | 5g | $109 | 2026-03-19 | Buy |
| Sigma-Aldrich | 255920 | 1,1′-(Azodicarbonyl)dipiperidine 99% | 10465-81-3 | 25g | $246 | 2026-03-19 | Buy |
| TCI Chemical | A1051 | 1,1'-(Azodicarbonyl)dipiperidine >98.0%(N) | 10465-81-3 | 5g | $78 | 2026-03-19 | Buy |
| TCI Chemical | A1051 | 1,1'-(Azodicarbonyl)dipiperidine >98.0%(N) | 10465-81-3 | 25g | $309 | 2026-03-19 | Buy |
| Cayman Chemical | 30486 | 1,1''-(Azodicarbonyl)dipiperidine | 10465-81-3 | 1g | $32 | 2024-03-01 | Buy |
1,1'-(Azodicarbonyl)-dipiperidine Chemical Properties,Uses,Production
Description
1,1''-(Azodicarbonyl)dipiperidine (ADDP) is a reagent commonly used in the Mitsunobu reaction for the condensation of an alcohol and an acidic compound. It has been used as a reagent in the synthesis of G protein-coupled receptor 120 (GPR120) agonists with antidiabetic activity and peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ triple agonists.
Chemical Properties
yellow crystalline powder
Uses
It is used in a study of the copper-catalyzed addition of aryboronic acids to azodicarboxyl derivatives providing aryl-substituted hydrazides. It is widely used reagent for the Mitsunobu reaction. It is reactant for preparation of polyfluoroalkylated tripyrazolylmethane ligands, (-)-Hygromycin A via Mitsunobu glycosylation, optically active α,α-disubstituted amino acids via Mitsunobu reaction, aza-β-lactams through [2+2] cycloaddition reactions, glycosyl disulfides, pyridine ether PPAR agonists, S-glycosyl amino acid, building blocks for combinatorial neoglycopeptide synthesis and is a histamine H3 receptor antagonists. It is a reactant for Mitsunobu inversion reactions.
Reactions
1,1'-(Azodicarbonyl)-dipiperidine can selectively oxidizes a variety of alcohols to the corresponding aldehydes or ketones under basic conditions.
IC 50
PPARα; PPAR-γ; PPARδ
References
[1] TETSUTO TSUNODA Sh I Yoshiko Yamamiya. 1,1′-(azodicarbonyl)dipiperidine-tributylphosphine, a new reagent system for mitsunobu reaction[J]. Tetrahedron Letters, 1993, 34 10: Pages 1639-1642. DOI: 10.1016/0040-4039(93)85029-v
[2] DAISUKE HIROSE. Systematic Evaluation of 2-Arylazocarboxylates and 2-Arylazocarboxamides as Mitsunobu Reagents[J]. The Journal of Organic Chemistry, 2018, 83 8: 4712-4729. DOI: 10.1021/acs.joc.8b00486
[3] XUQING ZHANG . Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists[J]. Bioorganic & Medicinal Chemistry Letters, 2017, 27 15: Pages 3272-3278. DOI: 10.1016/j.bmcl.2017.06.028
[4] JOHN P MOGENSEN. Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural template[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13 2: Pages 257-260. DOI: 10.1016/s0960-894x(02)00881-8
1,1'-(Azodicarbonyl)-dipiperidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 489 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| Suzhou BEC Biological Technology Co., Ltd. | +undefined13771885869 | all@bek.com.cn | China | 62 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 671 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29822 | 58 |
View Lastest Price from 1,1'-(Azodicarbonyl)-dipiperidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | 1,1'-(Azodicarbonyl)-dipiperidine
10465-81-3
|
US $0.00 / kg | 1kg | 98% | Customise | Hefei Lbao Physical & Chemical Science Co.,Ltd | |
 |
2026-01-04 | 1,1'-(Azodicarbonyl)-dipiperidine
10465-81-3
|
US $0.00-0.00 / kg | 0.1kg | 99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd | |
 |
2025-12-01 | 1,1'-(Azodicarbonyl)-dipiperidine
10465-81-3
|
US $0.00 / kg | 1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 1,1'-(Azodicarbonyl)-dipiperidine
10465-81-3
- US $0.00 / kg
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 1,1'-(Azodicarbonyl)-dipiperidine
10465-81-3
- US $0.00-0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- 1,1'-(Azodicarbonyl)-dipiperidine
10465-81-3
- US $0.00 / kg
- 99%
- Shaanxi Dideu New Materials Co. Ltd
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