1,2,4-Benzenetriol
- CAS No.
- 533-73-3
- Chemical Name:
- 1,2,4-Benzenetriol
- Synonyms
- 1,2,4-TRIHYDROXYBENZENE;Benzene-1,2,4-triol;HYDROXYHYDROQUINONE;1,2,4-Benzentril;Phloroglucinol Impurity 5;HHQ;NSC 2818;Oxyhydrochinon;OXYHYDROQUINONE;4-Hydroxycatechol
- CBNumber:
- CB8356419
- Molecular Formula:
- C6H6O3
- Molecular Weight:
- 126.11
- MDL Number:
- MFCD00002198
- MOL File:
- 533-73-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1,2,4-Trihydroxybenzene for synthesis | 8.43791 | 5G | $201 |
| 1,2,4-Trihydroxybenzene for synthesis | 8.43791 | 25g | $451 |
| 1,2,4-Benzenetriol ReagentPlus , 99% | 173401 | 1g | $92.1 |
| 1,2,4-Benzenetriol ReagentPlus , 99% | 173401 | 5g | $316 |
| 1,2,4-Trihydroxybenzene >98.0%(GC) | H0249 | 10g | $138 |
| More product size | |||
| Melting point | 140 °C (subl.) (lit.) |
|---|---|
| Boiling point | 194.21°C (rough estimate) |
| Density | 1.45 g/cm3 (20℃) |
| refractive index | 1.5627 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| pka | 9.58±0.10(Predicted) |
| form | Solid |
| color | Plates from Et2O |
| Water Solubility | freely soluble |
| Sensitive | Air Sensitive |
| Merck | 14,1073 |
| BRN | 2042863 |
| Stability | Light Sensitive, Moisture Sensitive |
| Cosmetics Ingredients Functions | HAIR DYEING |
| Cosmetic Ingredient Review (CIR) | 1,2,4-Benzenetriol (533-73-3) |
| InChI | 1S/C6H6O3/c7-4-1-2-5(8)6(9)3-4/h1-3,7-9H |
| InChIKey | GGNQRNBDZQJCCN-UHFFFAOYSA-N |
| SMILES | Oc1ccc(O)c(O)c1 |
| CAS DataBase Reference | 533-73-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 173O8B04RD |
| NIST Chemistry Reference | 1,2,4-Benzenetriol(533-73-3) |
| EPA Substance Registry System | 1,2,4-Benzenetriol (533-73-3) |
| UNSPSC Code | 12352104 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-37/38-41-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-39-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DC4200000 | |||||||||
| Hazard Note | Irritant/Keep Cold/Air Sensitive | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2907 29 00 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | oms-hmn:lym 50 mmol/L CNREA8 45,2471,85 | |||||||||
| NFPA 704 |
|
1,2,4-Benzenetriol price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.43791 | 1,2,4-Trihydroxybenzene for synthesis | 533-73-3 | 5G | $201 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.43791 | 1,2,4-Trihydroxybenzene for synthesis | 533-73-3 | 25g | $451 | 2025-07-31 | Buy |
| Sigma-Aldrich | 173401 | 1,2,4-Benzenetriol ReagentPlus , 99% | 533-73-3 | 1g | $92.1 | 2025-07-31 | Buy |
| Sigma-Aldrich | 173401 | 1,2,4-Benzenetriol ReagentPlus , 99% | 533-73-3 | 5g | $316 | 2025-07-31 | Buy |
| TCI Chemical | H0249 | 1,2,4-Trihydroxybenzene >98.0%(GC) | 533-73-3 | 10g | $138 | 2025-07-31 | Buy |
1,2,4-Benzenetriol Chemical Properties,Uses,Production
Chemical Properties
Gray powder
Physical properties
1,2,4-Benzenetriol forms colorless platelets or prisms that quickly colorize in air. It is soluble in water and polar solvents, and slightly soluble in chloroform and carbon disulfide.
Uses
1,2,4-Trihydroxybenzene is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.It is used as a metabolite of benzene.
Definition
ChEBI: Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
Production Methods
1,2,4-Benzenetriol is synthesized by hydrolysis of 1,2,4-triacetoxybenzene, which is prepared by the acid-catalyzed
reaction of p-benzoquinone with acetic anhydride.
Other production methods for 1,2,4-Benzenetriol are oxidation of resorcinol with hydrogen peroxide and Dakin oxidation of 2,4- or
3,4-dihydroxybenzaldehydes or 2,4- or 3,4-dihydroxyacetophenones with alkaline hydrogen peroxide solution.
General Description
1,2,4-Benzenetriol is also known as hydroxyhydroquinone. It is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
Chemical Reactivity
1,2,4-Benzenetriol is, like other phenols, a strong reducing agent. Its basic aqueous solution absorbs gaseous oxygen to produce black precipitates of the humic acid type. 1,2,4-Benzenetriol shows typical reactions of phenols. Derivatives of the tautomeric keto form are also known: halogenation of hydroxyhydroquinone, for example, gives 1,2,5,5-tetrahalocyclohexene-3,4,6-trione. Condensation with ethylacetoacetate produces dihydroxycoumarin; reaction with phthalic anhydride yields hydroxyhydroquinonephthalein. Monosubstitution of a hydroxy group by an amino group occurs easily at room temperature and gives 2,4-dihydroxyaniline.
Safety Profile
Poison by subcutaneous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Crystallise the triol from Et2O or Et2O/EtOH, and dry it in a vacuum. The picrate forms orange-red needles m 96o. [Beilstein 6 H 1087, 6 I 541, 6 II 1071, 6 III 6276.]
1,2,4-Benzenetriol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 | admin@hblongbang.com | China | 972 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3589 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5241 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 | L18532138899@163.com | China | 939 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21596 | 55 |
Related articles
- The Application of 1,2,4-Benzenetriol
- 1,2,4-Benzenetriol is a benzene ring compound bearing three hydroxyl functional groups and used in the synthesis of derivative....
- Oct 9，2025
View Lastest Price from 1,2,4-Benzenetriol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-26 | 1,2,4-Trihydroxybenzene
533-73-3
|
US $29.00 / mL | 99.69% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-02-26 | 1,2,4-Benzenetriol
533-73-3
|
US $0.00 / kg | 1kg | 98%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-12-12 | 1,2,4-Benzenetriol
533-73-3
|
US $300.00-210.00 / KG | 1KG | 99% | 2000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- 1,2,4-Trihydroxybenzene
533-73-3
- US $29.00 / mL
- 99.69%
- TargetMol Chemicals Inc.
-
- 1,2,4-Benzenetriol
533-73-3
- US $0.00 / kg
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 1,2,4-Benzenetriol
533-73-3
- US $300.00-210.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
