Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>L-Hydroxyproline

L-Hydroxyproline

L-Hydroxyproline Structure
L-Hydroxyproline structure
CAS No.
51-35-4
Chemical Name:
L-Hydroxyproline
Synonyms
TRANS-4-HYDROXY-L-PROLINE;Hyp;HYDROXYPROLINE;(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;4-HYDROXY-L-PROLINE;H-HYP-OH;4-Hydroxyproline;4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;4R-4-hydroxyproline;5kg
CBNumber:
CB8357870
Molecular Formula:
C5H9NO3
Molecular Weight:
131.13
MDL Number:
MFCD00064320
MOL File:
51-35-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
Product description Number Pack Size Price
Hydroxyproline Pharmaceutical Secondary Standard; Certified Reference Material PHR1939 500MG $201
trans-4-Hydroxy-L-proline ≥99% H54409 2.5g $43
trans-4-Hydroxy-L-proline BioXtra, ≥99.0% (NT) 56250 5 g $58.7
trans-4-Hydroxy-L-proline BioXtra, ≥99.0% (NT) 56250 100 g $360
trans-4-Hydroxy-L-proline analytical standard 41875 100mg $80.5
More product size
Request For Quotation

L-Hydroxyproline Properties

Melting point 273 °C (dec.)(lit.)
alpha -75.5 º (c=5, H2O)
Boiling point 242.42°C (rough estimate)
bulk density 610kg/m3
Density 1.3121 (rough estimate)
vapor density 4.5 (vs air)
refractive index -75.5 ° (C=4, H2O)
storage temp. Store below +30°C.
solubility H2O: 50 mg/mL
pka 1.82, 9.66(at 25℃)
form Crystals or Crystalline Powder
color White
Odor Odorless
PH 5.5-6.5 (50g/l, H2O, 20℃)
optical activity [α]25/D 75.6°, c = 1 in H2O
Water Solubility 357.8 g/L (20 º C)
Merck 14,4840
BRN 471933
Cosmetics Ingredients Functions HAIR CONDITIONING
ANTISTATIC
SURFACTANT - CLEANSING
SKIN CONDITIONING
InChI 1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChIKey PMMYEEVYMWASQN-DMTCNVIQSA-N
SMILES O[C@H]1CN[C@@H](C1)C(O)=O
LogP -0.350 (est)
CAS DataBase Reference 51-35-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) L-HYDROXYPROLINE
EWG's Food Scores 1
FDA UNII RMB44WO89X
NIST Chemistry Reference Hydroxyproline(51-35-4)
EPA Substance Registry System trans-4-Hydroxy-L-proline (51-35-4)
UNSPSC Code 85151701
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  24/25-36/37/39-27-26
WGK Germany  3
RTECS  TW3586500
TSCA  TSCA listed
HazardClass  IRRITANT
HS Code  29339990
Storage Class 11 - Combustible Solids
NFPA 704
1
0 0

L-Hydroxyproline price More Price(89)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1939 Hydroxyproline Pharmaceutical Secondary Standard; Certified Reference Material 51-35-4 500MG $201 2026-03-19 Buy
Sigma-Aldrich H54409 trans-4-Hydroxy-L-proline ≥99% 51-35-4 2.5g $43 2026-03-19 Buy
Sigma-Aldrich 56250 trans-4-Hydroxy-L-proline BioXtra, ≥99.0% (NT) 51-35-4 5 g $58.7 2026-03-19 Buy
Sigma-Aldrich 56250 trans-4-Hydroxy-L-proline BioXtra, ≥99.0% (NT) 51-35-4 100 g $360 2026-03-19 Buy
Sigma-Aldrich 41875 trans-4-Hydroxy-L-proline analytical standard 51-35-4 100mg $80.5 2026-03-19 Buy
Product number Packaging Price Buy
PHR1939 500MG $201 Buy
H54409 2.5g $43 Buy
56250 5 g $58.7 Buy
56250 100 g $360 Buy
41875 100mg $80.5 Buy

L-Hydroxyproline Chemical Properties,Uses,Production

Description

A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.

Chemical Properties

White crystalline powder

Uses

A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

Uses

A versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins.

Uses

hydroxyproline is a skin-conditioning amino acid. It is a component of collagen.

Definition

ChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration.

Production Methods

In the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix.
Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients.
Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

reaction suitability

reaction type: solution phase peptide synthesis

Biochem/physiol Actions

Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.

Purification Methods

Crystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]

L-Hydroxyproline synthesis

147-85-3
51-35-4
Synthesis of L-Hydroxyproline from L-Proline

L-Hydroxyproline Preparation Products And Raw materials

Raw materials

Soy bean Isoflavone Isoflavone 10-40% Α-protein Bone glue Casein Gelatin

Preparation Products

N-Boc-cis-4-Hydroxy-L-proline methyl ester (R)-(-)-3-Pyrrolidinol hydrochloride (2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride N-Boc-4-oxo-L-Proline methyl ester
Fmoc-L-hydroxyproline 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-methyl-, 1,1-dimethylethyl ester, (2S,4S)- 2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- BETONICINE
TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE N-CBZ-CIS-4-HYDROXY-D-PROLINE METHYL ESTER 1-BENZYLPYRROLE 1-PHENYLPYRROLE

1of3

L-Hydroxyproline Suppliers

Global( 1095)Suppliers
Supplier Tel Email Country ProdList Advantage
BTC pharm India
+918790379245 banny.janga@btcpharm.com India 1262 58
Henan Rane Chemical Co., Ltd.
+8618738066252 info@ranechem.com China 2999 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-18192627656 1059@dideu.com China 3590 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5235 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Hebei Longbang Technology Co., LTD 		+86-18633929156 admin@hblongbang.com China 972 58
Shandong Deshang Chemical Co., Ltd. 		+86-0531-8875-2665 +8613153039501 info@deshangchem.com China 661 58
Supplier Advantage
BTC pharm India
58
Henan Rane Chemical Co., Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Hebei Longbang Technology Co., LTD 		58
Shandong Deshang Chemical Co., Ltd. 		58

Related articles

View Lastest Price from L-Hydroxyproline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-Hydroxyproline pictures 2026-04-30 L-Hydroxyproline
51-35-4
 US $0.00 / Kg/Drum 1KG 98.5%-101.0%; AJI92 10 TONS WUHAN FORTUNA CHEMICAL CO., LTD
L-Hydroxyproline pictures 2026-04-29 L-Hydroxyproline
51-35-4
 0.99 RongNa Biotechnology Co.,Ltd
L-Hydroxyproline pictures 2026-04-22 L-Hydroxyproline
51-35-4
 US $0.00 / removed 99.92% 10g TargetMol Chemicals Inc.
  • L-Hydroxyproline pictures
  • L-Hydroxyproline
    51-35-4
  • US $0.00 / Kg/Drum
  • 98.5%-101.0%; AJI92
  • WUHAN FORTUNA CHEMICAL CO., LTD

L-Hydroxyproline Spectrum

L-Hydroxyproline(51-35-4)MSL-Hydroxyproline(51-35-4)1HNMRL-Hydroxyproline(51-35-4)13CNMRL-Hydroxyproline(51-35-4)IR1L-Hydroxyproline(51-35-4)IR2L-Hydroxyproline(51-35-4)Raman

51-35-4(L-Hydroxyproline)Related Search:

trans,trans-2,4-Undecadienal trans-4-Hydroxy-D-proline D-Proline trans-4-Hydroxy-L-proline methyl ester hydrochloride CHLOROPHOSPHONAZO III
L-Proline N-Acetyl-L-Hydroxyproline L-PROLINE-(4-3H(N)) L-Leucine Methyl L-leucinate hydrochloride
L-(+)-Prolinol cis-4-Hydroxy-L-proline Boc-Hyp-OH cis-4-Hydroxy-D-proline BETONICINE
(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER BOC-HYP(BZL)-OH Fmoc-Hyp(tBu)-OH

1of4

H-HYP-OH (TRANS) H-L-HYDROXYPROLINE H-L-HYP-OH H-TRANS-HYP-OH HYDROXY-L-PROLINE HYDROXY-L-PROLINE, TRANS-4- HYDROXYPROLINE, L- L-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID L-4-TRANS-HYDROXYPROLINE L-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID L-4-HYDROXY-2-PYRROLIDINE-CARBOXYLIC ACID TRANS-ISOMER L4-4-HYDROXY-2-PYRROLIDINE-CARBOXYLIC ACID TRANS ISOMER L-TRANS-4-HYDROXYPROLINE L-HYDROXYPROLINE L-trans-4-Hydroxy-L-proline L-Hydroxyproline AJI92 -HydroxyproL (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acidHyp 4-hydroxy-L-proline (trans) TRANS-4-HYDROXY-L-PROLINE, 99+% L-HydroxyprolineForBiochemistry L-Hydroxyproline99+% L-HYDROXYPROLINE ( AKA ) TRANS 4 HYDROXY L PROLINE TRANS 4 HYDROXY L PROLINE (HYPRO) TRANS-L-HYDROXYPROLINE, (2S,4R)-(-)-4-HYDROXY-2-PYRROLINECARBOXYLIC ACID L-Proline, 4-hydroxy-, (4R)- L-HYDROXY PROLINE/TRANS-L-4-HYDROXYPROLINE L-HYDROXYPROLINE51-35-4 HYDROXY-L-PROLINE, trans-4-(RG) (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic TRANS-4-HYDROXY-L-PROLINE (MICROBIAL & L(-)-Hydroxy-4 proline 4-HYDROXY-L-PROLINE 99% L-HYDROXYPROLINE extrapure CHR trans-4-Hydroxy-L-proline, (4R)-4-Hydroxy-L-proline HPDR HPDR1 PHEX trans-4-Hydroxy-L-proline Vetec(TM) reagent grade, 99% L-Proline, 4-hydroxy-, trans- (9CI) L-threo-4-hydroxyproline Proline, 4-hydroxy- (VAN) allo-4-Hydroxyproline allo-L-Hydroxyproline D-Proline, 4-hydroxy-, cis- L-Proline, 4-hydro L-Proline, 4-hydroxy-, cis- L-Proline, allo-hydroxy- OH-pro oxyproline Proline, 4-allo-hydroxy-, L- Pyrrolidin-4-ol-2-carboxylic acid Trans-4-hydroxy-proline -L- (R)-4-Hydroxy-(S)-proline 4(R)-Hydroxy-2(S)-pyrrolidinecarboxylic Acid 4-trans-Hydroxy-L-proline NSC 46704 L-Hydroxyproline (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid