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Pterostilbene

Pterostilbene Structure
Pterostilbene structure
CAS No.
537-42-8
Chemical Name:
Pterostilbene
Synonyms
pterostibene;hydroxystilbene;PTEROCARPUS MARSUPIUM;nootropic blueberry extract Pterostilbene;AKOS 236-80;PTEROSTILBENE;(Z)-3,4’-aminostilbene;(E/Z)-3,4’POVIDONE USP(RG)
CBNumber:
CB8373368
Molecular Formula:
C16H16O3
Molecular Weight:
256.3
MDL Number:
MFCD00238710
MOL File:
537-42-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 18:53:57
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Pterostilbene Properties

Melting point 89-92 ºC
Boiling point 420.4±35.0 °C(Predicted)
Density 1.169±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
pka 9.96±0.26(Predicted)
form solid
color White or off-white
Odor Characteristic
λmax 321nm(MeOH)(lit.)
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Cosmetics Ingredients Functions SKIN CONDITIONING
ANTIOXIDANT
InChI InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
InChIKey VLEUZFDZJKSGMX-ONEGZZNKSA-N
SMILES C1(O)=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1
LogP 4.056 (est)
EWG's Food Scores 1
FDA UNII 26R60S6A5I
NCI Drug Dictionary pterostilbene
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Environment (GHS09)
GHS05,GHS09
Signal word  Danger
Hazard statements  H318-H411
Precautionary statements  P273-P280-P305+P351+P338-P391-P501
Hazard Codes  Xi,N
Risk Statements  41-51/53
Safety Statements  26-39-61
RIDADR  3077
WGK Germany  3
HazardClass  IRRITANT
PackingGroup  Ⅲ
HS Code  29095000
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Chronic 2
Eye Dam. 1
NFPA 704
0
3 0

Pterostilbene price More Price(93)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL83261 trans-Pterostilbene phyproof® Reference Substance 537-42-8 10 mg $343 2026-04-30 Buy
Sigma-Aldrich P1499 Pterostilbene ≥97% (HPLC), solid 537-42-8 10mg $340 2026-04-30 Buy
Sigma-Aldrich 523310 Pterostilbene 537-42-8 10mg $242 2026-04-30 Buy
TCI Chemical P1924 Pterostilbene >98.0%(HPLC) 537-42-8 100mg $21 2026-04-30 Buy
TCI Chemical P1924 Pterostilbene >98.0%(HPLC) 537-42-8 1g $31 2026-04-30 Buy
Product number Packaging Price Buy
PHL83261 10 mg $343 Buy
P1499 10mg $340 Buy
523310 10mg $242 Buy
P1924 100mg $21 Buy
P1924 1g $31 Buy

Pterostilbene Chemical Properties,Uses,Production

Description

Pterostilbene (PTS) is a fragrant-smelling hydrocarbon called "styrene", which is a derivative of resveratrol. It is found in blueberries and Pterocarpus marsupium (PM) heartwood. Similar to resveratrol, PTS has anti-inflammatory, anti-thrombotic, anti-cancer, anti-cancer, anti-hyperlipidemia and antibacterial effects.

Chemical Properties

Pterostilbene is a white crystalline powder, sensitive to air, soluble in hot methanol, DMSO, insoluble in water. It is a stilbenoid chemically similar to resveratrol and from the leguminous plant Pterocarpus indicus.

Occurrence

Pterostilbene is a natural molecule found in fruits, vegetables and nuts. Blueberries are often quoted as one of the richest sources of pterostilbene. It is also found in almonds,various Vaccinium berries (including blueberries), grape leaves and vines,and Pterocarpus marsupium heartwood.

Uses

Substantial studies demonstrate that pterostilbene has diverse pharmacological activities for the prevention and treatment of diseases including inflammation, cancer, diabetes, and dyslipidemia.
Pterostilbene has been used:
to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway
to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)

Definition

ChEBI: Pterostilbene is a stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'. It has a role as an antioxidant, an antineoplastic agent, a neurotransmitter, a plant metabolite, an apoptosis inducer, a neuroprotective agent, an anti-inflammatory agent, a radical scavenger and a hypoglycemic agent. It is a stilbenol, a member of methoxybenzenes and a diether. It derives from a hydride of a trans-stilbene.

Preparation

Pterostilbene was synthesized from 3,5-dimethoxybenzyl bromide and p-nitrobenzaldehyde by Witting-Hornor reaction, reduction, diazotization and hydrolysis, with a total yield of 53.9%.
synthesis of Pterostilbene

benefits

Pterostilbene is a naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Pterostilbene is known to have many pharmacological benefits for the prevention and treatment of a wide variety of diseases, including ( cancer (McCormack and McFadden 2012), dyslipidaemia (Rimando et al. 2005), diabetes (Amarnath Satheesh and Pari 2006), cardiovascular degeneration (Amarnath Satheesh and Pari 2008) and pain (Hougee et al. 2005).

Biological Activity

A cell-permeable methoxylated analog of Resveratrol that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox. Moderately inhibits COX-1 & COX-2 activities (IC50 = 19.8 μM & 83.9 μM, respectively) and induces apoptosis in HL60 cells (IC50 = 70 μM). Also prevents DMBA-induced pre-neoplastic lesions (ED50 = 4.8 μM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin.

Side effects

The side effects of pterostilbene are relatively minor, but you still need to pay attention to the dosage. Low-dose pterostilbene supplementation improves cholesterol metabolism and reduces triglyceride levels. Side effects include mild weight loss and muscle pain, but dose adjustment is usually not necessary.

References

[1] ESTRELAJOSé M. Pterostilbene: Biomedical applications.[J]. Critical reviews in clinical laboratory sciences, 2013. DOI:10.3109/10408363.2013.805182.
[2] HYUNSOOK KIM  Wallace Y  Kun Ho Seo. Chemistry of Pterostilbene and Its Metabolic Effects[J]. Journal of Agricultural and Food Chemistry, 2020. DOI:10.1021/acs.jafc.0c00070.
[3] MACICKOVATATIANA. In vivo effect of pinosylvin and pterostilbene in the animal model of adjuvant arthritis.[J]. Neuro endocrinology letters, 2010.
[4] WASAMON NUTAKUL. Inhibitory Effects of Resveratrol and Pterostilbene on Human Colon Cancer Cells: A Side-by-Side Comparison[J]. Journal of Agricultural and Food Chemistry, 2011. DOI:10.1021/jf202846b.

Pterostilbene Preparation Products And Raw materials

Raw materials

4-Nitrobenzaldehyde 3,5-Dimethoxybenzyl bromide

Preparation Products

Pterostilbene Suppliers

Global( 670)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou Great Forest Biomedical Ltd. 0571-28313180 17767135330 info@great-forest.com China 55 58
Wuxi Cima Science Co.,Ltd 0510-0510-85188225 18061978815 info@cimasci.com China 18 58
Shanxi Yuning Biotechnology Co., Ltd. 13623677056 1039999500@qq.com China 511 58
Beri Pharma Co., Ltd. 0756-8699456 13427714006 sales@zhberi.com China 199 58
Shaanxi Pioneer Biotech Co.,Ltd. 029-84385017-8011 15202491660 sales8@pioneerbiotech.com China 449 58
Zhuhai Huachen Pharmaceutical Technology Co., Ltd 15916275916 290113728@qq.com China 53 58
Hangzhou Lin'an tianhong biotechnology co.,ltd. 13606615626; 15957181975 hu@tianhongsw.com China 54 58
Suzhou Daolan Biomedical Technology Co., Ltd. 15952404857 sales@dolanpharm.com China 2967 58
Shandong Yuanlitai Nutratech Co., Ltd， 18668987081 18980869808 info@yltnutra.com China 19 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Hangzhou Great Forest Biomedical Ltd. 58
Wuxi Cima Science Co.,Ltd 58
Shanxi Yuning Biotechnology Co., Ltd. 58
Beri Pharma Co., Ltd. 58
Shaanxi Pioneer Biotech Co.,Ltd. 58
Zhuhai Huachen Pharmaceutical Technology Co., Ltd 58
Hangzhou Lin'an tianhong biotechnology co.,ltd. 58
Suzhou Daolan Biomedical Technology Co., Ltd. 58
Shandong Yuanlitai Nutratech Co., Ltd， 58
J & K SCIENTIFIC LTD. 76

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View Lastest Price from Pterostilbene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pterostilbene pictures 2026-09-13 Pterostilbene
537-42-8
 0.99 RongNa Biotechnology Co.,Ltd
Pterostilbene pictures 2026-09-12 Pterostilbene
537-42-8
 1KG 0.98 10000 KG Nanjing pathgene biotech co .,ltd
Pterostilbene pictures 2026-09-11 Pterostilbene
537-42-8
 1kg 98% 1000 Changsha Staherb Natural Ingredients Co., Ltd.
  • Pterostilbene pictures
  • Pterostilbene
    537-42-8
  • 98%
  • Changsha Staherb Natural Ingredients Co., Ltd.

Pterostilbene Spectrum

Pterostilbene(537-42-8)1HNMR

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AKOS 236-80 3,5-DIMETHOXY-4'-HYDROXYSTILBENE 3',5'-DIMETHOXY-4-STILBENOL 4-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]PHENOL PTEROSTILBENE TRANS-3,5-DIMETHOXY-4'-HYDROXYSTILBENE (E)-3,5-Dimethoxy-4'-hydroxystilbene (E)-3',5'-Dimethoxystilbene-4-ol 4-[(E)-2-(3,5-Dimethoxyphenyl)vinyl]phenol 4-[(E)-3,5-Dimethoxystyryl]phenol trans- Pterostilbene Pterostilbene IN STOCK Pterostilbene Factory Pterostilbene COA Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem NanoLiposomal Pterostilbene nootropic blueberry extract Pterostilbene powder (Z)-3,4&rsquo 5-Trimethoxy-3&rsquo Pterostilbene CAS 537-42-8 Phenol,4-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]- 3,5-DiMethoxy-4'-hydroxy-trans-stilbene Phenol,4-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]- Pterostilbene 3',5'-Dimethoxy-4-stilbenol 3,5-Dimethoxy-4'-hydroxy-trans-stilbene 4-(2-(3,5-Dimethoxyphenyl) 4-[2-(3,5-dimethoxyphenyl)ethenyl]phenol 4-[2-(3,5-dimethoxyphenyl)vinyl]phenol 4-Stilbenol, 3',5'-dimethoxy-, (E)- Pterostilbene 99.8% BioaActive Pterostilbene Nanoactive Pterostilbene Soluble Pterostilbene (E/Z)-3,4&rsquo -aminostilbene -(tert-butyldimethylsilyloxy)stilbene Liposomal PTEROSTILBENE, PTEROSTILBENE NanoEmulsion, NanoActive PTEROSTILBENE,Water/Oil-Soluble PTEROSTILBENE hydroxystilbene Phenol, 4-(2-(3,5-dimethoxyphenyl)ethenyl)-, (E)- Pterostilbene, Pterocarpus marsupium trans-3,5-Dimethoxy-4&prime Pterostilbene, Pterocarpus marsupium 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol, Pterocarpus marsupium (E)-4-[2-(3,5-dimethoxyphenyl)ethenyl]-Phenol -4-(3,5-Dimethoxystyryl) phenol, 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]- POVIDONE USP(RG) PTEROSTILBENE(FG) PTEROSTILBENE(DS) 4-(3,5-DiMethoxystyryl)phenol 4'-Hydroxy-3,5-dimethoxy-trans-stilbene trans-1-(3,5-Dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene 4'-Hydroxy-3,5-diMethoxystilbene PTEROSTILBENE(FG)(REQUEST QUOTE) Pterostilbene> Pterostilbene powder 4'-Hydroxy-3,5-dimethoxy-trans-stilbene trans-1-(3,5-Dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene Pterostilbene Powder CAS No 537-42-8 Pterostilbene 98% 3,5-Dimethoxy-4-hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol, Pteris tatarinowii