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2-Bromo-4-chloroanisole

2-Bromo-4-chloroanisole structure

CAS No.: 60633-25-2

Chemical Name:: 2-Bromo-4-chloroanisole

Synonyms: 2-Bromo-4-chloroanis;2-BROMO-4-CHLOROANISOLE;4-Chloro 2-BroMo Anisole;2-Bromo-4-chloroanisole >2-Bromo-4-chloroanisole,98%;2-BroMo-4-chloroanisole, 98% 25ML;2-BROMO-4-CHLORO-1-METHOXY-BENZENE;Benzene, 2- bromo- 4- chloro- 1- methoxy-;2-Bromo-4-chloro-1-methoxybenzene, 2-Bromo-4-chlorophenyl methyl ether

CBNumber:: CB8380603

Molecular Formula:: C7H6BrClO

Molecular Weight:: 221.48

MDL Number:: MFCD00079705

MOL File:: 60633-25-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-10 10:27:30

Product description	Number	Pack Size	Price
2-Bromo-4-chloroanisole >98.0%(GC)	B3111	5g	$23
2-Bromo-4-chloroanisole >98.0%(GC)	B3111	25g	$76
2-Bromo-4-chloroanisole	B681940	1g	$45
2-Bromo-4-chloroanisole 99%	001630	100g	$49
2-Bromo-4-chloroanisole	2607-D-X2	100g	$56
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2-Bromo-4-chloroanisole Properties

Melting point	28.6-29.1°C
Boiling point	122/20mm
Density	1.625
vapor pressure	8.7Pa at 25℃
refractive index	1.5850-1.5890
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Liquid
Specific Gravity	1.61
color	Clear colorless to pale yellow
Henry's Law Constant	1.8×10^-2 mol/(m³Pa) at 25℃, Pfeifer et al. (2001)
CAS DataBase Reference	60633-25-2(CAS DataBase Reference)
NIST Chemistry Reference	2-Bromo-4-chloroanisole(60633-25-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P271-P280
Hazard Codes	Xi,Xn
Risk Statements	36/37/38-51-22
Safety Statements	24/25
HazardClass	IRRITANT
HS Code	29093090

2-Bromo-4-chloroanisole price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B3111	2-Bromo-4-chloroanisole >98.0%(GC)	60633-25-2	5g	$23	2026-03-19	Buy
TCI Chemical	B3111	2-Bromo-4-chloroanisole >98.0%(GC)	60633-25-2	25g	$76	2026-03-19	Buy
TRC	B681940	2-Bromo-4-chloroanisole	60633-25-2	1g	$45	2021-12-16	Buy
Matrix Scientific	001630	2-Bromo-4-chloroanisole 99%	60633-25-2	100g	$49	2021-12-16	Buy
SynQuest Laboratories	2607-D-X2	2-Bromo-4-chloroanisole	60633-25-2	100g	$56	2021-12-16	Buy

Product number	Packaging	Price	Buy
B3111	5g	$23	Buy
B3111	25g	$76	Buy
B681940	1g	$45	Buy
001630	100g	$49	Buy
2607-D-X2	100g	$56	Buy

2-Bromo-4-chloroanisole Chemical Properties,Uses,Production

Chemical Properties

Clear colorless to pale yellow liquid

Uses

2-Bromo-4-chloroanisole has been used as a reactant in the preparation of naphthyl phenyl ethers as nonnucleoside HIV-1 reverse transcriptase inhibitors.

Synthesis

695-96-5

74-88-4

60633-25-2

General procedure for the synthesis of 2-bromo-4-chloroanisole from 2-bromo-4-chlorophenol and iodomethane: In a 250 mL round-bottomed flask, 2-bromo-4-chlorophenol (16.94 g, 81.6 mmol, 1.0 eq.) was dissolved in acetone (160 mL), and iodomethane (6.10 mL, 98 mmol, 1.2 eq.), potassium carbonate (12 g), and water (4 mL). The reaction mixture was heated to reflux for 3 h. After cooling to room temperature, most of the volatiles were removed under reduced pressure. The residue was poured into water (140 mL) and extracted with ethyl acetate (3 x 150 mL). The organic phases were combined, washed with brine (1 x 100 mL), dried (K2CO3), filtered through a pad of diatomaceous earth and concentrated to give a clear oil. Purification by short-range distillation (80°-85 °C, 1 Torr) afforded 17.74 g (98% yield) of 2-bromo-4-chloroanisole as a clear liquid. 2-bromo-4-chloroanisole was characterized by NMR hydrogen spectroscopy (400 MHz, acetone-d6) with the following data: δ 7.53 (d, J = 2.5 Hz, 1H); 7.24 (dd, J = 9.7, 2.5 Hz. 1H); 6.81 (d, J = 9.7 Hz, 1H); 3.88 (s, 3H).

References

[1] Angewandte Chemie - International Edition, 2008, vol. 47, # 27, p. 5067 - 5070
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 14, p. 4220 - 4226
[3] Angewandte Chemie - International Edition, 2014, vol. 53, # 25, p. 6443 - 6448
[4] Angew. Chem., 2014, vol. 126, # 25, p. 6561 - 6566
[5] Patent: US5688808, 1997, A

2-Bromo-4-chloroanisole Preparation Products And Raw materials

Raw materials

2-Bromo-4-chlorophenol 4-Chloroanisole Dimethyl sulfate Iodomethane Water

Acetone Potassium carbonate

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Preparation Products

3-BROMO-5-CHLORO-2-METHOXYANILINE

2-Bromo-4-chloroanisole Suppliers

Global( 241)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13843	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29820	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Hefei Hirisun Pharmatech Co., Ltd	58

View Lastest Price from 2-Bromo-4-chloroanisole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	2-Bromo-4-chloroanisole 60633-25-2	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2019-07-06	2-Bromo-4-chloroanisole 60633-25-2	US $1.00 / KG	1KG	99%	Customized	Career Henan Chemical Co

2-Bromo-4-chloroanisole
60633-25-2
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Bromo-4-chloroanisole
60633-25-2
US $1.00 / KG
99%
Career Henan Chemical Co

2-Bromo-4-chloroanisole Spectrum

2-Bromo-4-chloroanisole(60633-25-2)¹HNMR

60633-25-2(2-Bromo-4-chloroanisole)Related Search:

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2-BROMO-4-CHLORO-1-METHOXY-BENZENE 2-BROMO-4-CHLOROANISOLE 2-Bromo-4-chloroanis 2-BroMo-4-chloroanisole, 98% 25ML 2-Bromo-4-chloroanisole,98% 4-Chloro 2-BroMo Anisole 2-Bromo-4-chloro-1-methoxybenzene, 2-Bromo-4-chlorophenyl methyl ether Benzene, 2- bromo- 4- chloro- 1- methoxy- 2-Bromo-4-chloroanisole > 60633-25-2 C7H6OBrCl Anisole Anisoles, Alkyloxy Compounds & Phenylacetates Bromine Compounds Chlorine Compounds