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2-Chloro-6-fluorobenzothiazole

2-Chloro-6-fluorobenzothiazole structure

CAS No.: 399-74-6

Chemical Name:: 2-Chloro-6-fluorobenzothiazole

Synonyms: IFLAB-BB F1910-0016;2-CHLORO-6-FLUOROBENZOTHIAZOLE;2-CHLORO-6-FLUOROBENZO[D]THIAZOLE;Benzothiazole, 2-chloro-6-fluoro-;2-CHLORO-6-FLUORO-1,3-BENZOTHIAZOLE;Benzothiazole, 2-chloro-6-fluoro- (8CI,9CI);JR-8570, 2-Chloro-6-fluorobenzo[d]thiazole, 97%

CBNumber:: CB8380946

Molecular Formula:: C7H3ClFNS

Molecular Weight:: 187.62

MDL Number:: MFCD04448822

MOL File:: 399-74-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:09

Product description	Number	Pack Size	Price
2-Chloro-6-fluorobenzothiazole 97%	667358	1g	$57.4
2-Chloro-6-fluorobenzothiazole 97%	667358	5g	$245
2-Chloro-6-fluorobenzothiazole >98.0%(GC)	C2607	1g	$104
2-Chloro-6-fluorobenzothiazole >98.0%(GC)	C2607	5g	$411
2-Chloro-6-fluorobenzo[d]thiazole ≥98%(HPLC)	25928	1G	$67.6
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2-Chloro-6-fluorobenzothiazole Properties

Melting point	91-95 °C
Boiling point	253.0±13.0 °C(Predicted)
Density	1.532±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-0.39±0.10(Predicted)
form	powder to crystal
color	White to Light yellow
InChI	1S/C7H3BrFNS/c8-7-10-5-2-1-4(9)3-6(5)11-7/h1-3H
InChIKey	GIANOUBNTGQAID-UHFFFAOYSA-N
SMILES	Fc1ccc2nc(Br)sc2c1
CAS DataBase Reference	399-74-6(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

WGK Germany

HS Code

29342000

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

2-Chloro-6-fluorobenzothiazole price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	667358	2-Chloro-6-fluorobenzothiazole 97%	399-74-6	1g	$57.4	2023-06-20	Buy
Sigma-Aldrich	667358	2-Chloro-6-fluorobenzothiazole 97%	399-74-6	5g	$245	2023-06-20	Buy
TCI Chemical	C2607	2-Chloro-6-fluorobenzothiazole >98.0%(GC)	399-74-6	1g	$104	2026-04-30	Buy
TCI Chemical	C2607	2-Chloro-6-fluorobenzothiazole >98.0%(GC)	399-74-6	5g	$411	2026-04-30	Buy
Chem-Impex	25928	2-Chloro-6-fluorobenzo[d]thiazole ≥98%(HPLC)	399-74-6	1G	$67.6	2026-05-19	Buy

Product number	Packaging	Price	Buy
667358	1g	$57.4	Buy
667358	5g	$245	Buy
C2607	1g	$104	Buy
C2607	5g	$411	Buy
25928	1G	$67.6	Buy

2-Chloro-6-fluorobenzothiazole Chemical Properties,Uses,Production

Chemical Properties

White solid

Biological Activity

2-Chloro-6-fluorobenzothiazole is a potent inhibitor of diacylglycerol acyltransferase, an enzyme involved in the biosynthesis of triglycerides. It has been shown to inhibit the enzymatic activity of this enzyme and decrease triglyceride levels by inhibiting the production of fatty acids.

Synthesis

348-40-3

399-74-6

General procedure for the synthesis of 2-chloro-6-fluorobenzothiazole from 2-amino-6-fluorobenzothiazole: In a round-bottomed flask, 2-amino-6-fluorobenzothiazole (1.0017 g, 5.96 mmol, Sigma-Aldrich Chemical Company, Inc.), copper(II) chloride (1.201 g, 8.93 mmol, Sigma-Aldrich Chemical Company, Inc.) and tert-butyl nitrite (1.063 mL, 8.93 mmol, Acros Organics) in acetonitrile (ACN). The reaction mixture was heated to 65 °C and kept at this temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with 1N hydrochloric acid and extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with water and saturated sodium chloride solution, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target product 2-chloro-6-fluorobenzothiazole (0.9249 g, 4.93 mmol, 83% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.45 (td, J = 9.10, 2.74 Hz, 1H), 7.97-8.07 (m, 2H).

References

[1] Patent: US2013/225552, 2013, A1. Location in patent: Paragraph 0976
[2] Patent: WO2012/69503, 2012, A1. Location in patent: Page/Page column 18-19
[3] Patent: US2013/172326, 2013, A1. Location in patent: Paragraph 0081; 0082
[4] Journal of the Indian Chemical Society, 1933, vol. 10, p. 465,469
[5] Farmaco, Edizione Scientifica, 1977, vol. 32, p. 348 - 354

2-Chloro-6-fluorobenzothiazole Preparation Products And Raw materials

Raw materials

6-Fluoro-benzothiazole-2-thiol 2-Amino-6-fluorobenzothiazole Acetonitrile tert-Butyl nitrite Copper(II) chloride

Preparation Products

2-Chloro-6-fluorobenzothiazole Suppliers

Global( 172)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29793	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from 2-Chloro-6-fluorobenzothiazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-01-15	2-Chloro-6-fluorobenzo[d]thiazole 399-74-6	US $0.00 / KG	1KG	99.4%	100 tons	Honest Joy Holdings Limited
2021-07-13	2-Chloro-6-fluorobenzothiazole 399-74-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-12-25	2-Chloro-6-fluorobenzothiazole 399-74-6	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

2-Chloro-6-fluorobenzo[d]thiazole
399-74-6
US $0.00 / KG
99.4%
Honest Joy Holdings Limited

2-Chloro-6-fluorobenzothiazole
399-74-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Chloro-6-fluorobenzothiazole
399-74-6
US $1.00 / KG
99%
Career Henan Chemical Co

2-Chloro-6-fluorobenzothiazole Spectrum

2-Chloro-6-fluorobenzothiazole(399-74-6)¹HNMR 2-Chloro-6-fluorobenzothiazole(399-74-6)¹⁹FNMR

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IFLAB-BB F1910-0016 2-CHLORO-6-FLUOROBENZO[D]THIAZOLE JR-8570, 2-Chloro-6-fluorobenzo[d]thiazole, 97% 2-CHLORO-6-FLUOROBENZOTHIAZOLE 2-CHLORO-6-FLUORO-1,3-BENZOTHIAZOLE Benzothiazole, 2-chloro-6-fluoro- (8CI,9CI) Benzothiazole, 2-chloro-6-fluoro- 399-74-6 Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Thiazoles BENZOTHIAZOLE Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Thiazoles ThiazolesHeterocyclic Building Blocks