4-FLUORO-2-METHOXYACETOPHENONE
- CAS No.
- 51788-80-8
- Chemical Name:
- 4-FLUORO-2-METHOXYACETOPHENONE
- Synonyms
- 2-methoxy-4-fluoroacetophenone;4-FLUORO-2-METHOXYACETOPHENONE;4'-Fluoro-2'-methoxyacetophenone;4'-Fluoro-2'-methoxyacetophenone98%;4'-Fluoro-2'-methoxyacetophenone 98%;1-(4-fluoro-2-methoxyphenyl)ethanone;Ethanone, 1-(4-fluoro-2-methoxyphenyl)-;4′-Fluoro-2′-methoxyacetophenone, CAS 51788-80-8;4'-fluoro-2'-methoxyacetophenone,1-(4-fluoro-2-methoxyphenyl)ethanone
- CBNumber:
- CB8382814
- Molecular Formula:
- C9H9FO2
- Molecular Weight:
- 168.16
- MDL Number:
- MFCD00061143
- MOL File:
- 51788-80-8.mol
| Melting point | 51 °C |
|---|---|
| Boiling point | 228.4±20.0 °C(Predicted) |
| Density | 1.127±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | crystalline powder |
| color | White |
| BRN | 2251986 |
| CAS DataBase Reference | 51788-80-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2914500090 | |||||||||
| NFPA 704 |
|
4-FLUORO-2-METHOXYACETOPHENONE price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F597448 | 4''-Fluoro-2''-methoxyacetophenone | 51788-80-8 | 1g | $75 | 2021-12-16 | Buy |
| Matrix Scientific | 001409 | 4'-Fluoro-2'-methoxyacetophenone 98% | 51788-80-8 | 25g | $115 | 2021-12-16 | Buy |
| AK Scientific | J56857 | 4-Fluoro-2-methoxyacetophenone | 51788-80-8 | 1g | $14 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2617-3-14 | 4'-Fluoro-2'-methoxyacetophenone 98% | 51788-80-8 | 1g | $16 | 2021-12-16 | Buy |
| Matrix Scientific | 001409 | 4'-Fluoro-2'-methoxyacetophenone 98% | 51788-80-8 | 5g | $33 | 2021-12-16 | Buy |
4-FLUORO-2-METHOXYACETOPHENONE Chemical Properties,Uses,Production
Uses
4''-Fluoro-2''-methoxyacetophenone
Preparation
Preparation by reaction of methyl iodide with 4-fluoro-2-hydroxyacetophenone in the presence of potassium carbonate,
? in DMSO at r.t. for 1 h (100%);
? in acetone (97%).
Synthesis
1481-27-2
74-88-4
51788-80-8
4-Fluoro-2-hydroxyacetophenone (12.0 g, 77.9 mmol) was reacted with iodomethane (6.38 ml, 101 mmol) and potassium carbonate (14.0 g, 101 mmol) in acetonitrile (200 ml) at 75 °C for 8 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered and concentrated under reduced pressure to remove the solvent. To the residue was added fresh acetonitrile (150 ml), iodomethane (2 ml, 32 mmol) and potassium carbonate (4 g, 29 mmol) and the reaction was continued at 75°C for 3 hours. The reaction mixture was concentrated, diluted by adding ethyl acetate (100 ml), filtered and the solvent was evaporated under reduced pressure to give 4-fluoro-2-methoxyacetophenone (13.5 g, 100% yield). Mass spectral data: m/z 168 (M+, 11), 153 (base peak), 110 (23), 95 (21), 82 (12).
References
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 15, p. 3823 - 3842
[2] Patent: WO2009/133110, 2009, A1. Location in patent: Page/Page column 38
[3] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1590 - 1595
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 4, p. 1583 - 1598
[5] Journal of Medicinal Chemistry, 1999, vol. 42, # 20, p. 4150 - 4160
4-FLUORO-2-METHOXYACETOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20191 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3969 | 58 |
View Lastest Price from 4-FLUORO-2-METHOXYACETOPHENONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-02 | 4'-Fluoro-2'-methoxyacetophenone
51788-80-8
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2020-01-09 | 4-FLUORO-2-METHOXYACETOPHENONE
51788-80-8
|
US $1.00 / KG | 1KG | 98% HPLC | 10 tons/month | Career Henan Chemical Co |
-
- 4'-Fluoro-2'-methoxyacetophenone
51788-80-8
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 4-FLUORO-2-METHOXYACETOPHENONE
51788-80-8
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co
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