Tocofersolan
- CAS No.
- 9002-96-4
- Chemical Name:
- Tocofersolan
- Synonyms
- tpgs;VITAMIN E TPGS;Vitamin E polyethylene glycol succinate;d-alpha-tocopheryl polyethylene glycol succinate;Tocophersolan;D-α-Tocopherol polyethylene glycol succinate;tocopherosolan;D-a-Tocopherol Polyethylene Glycol Succinate;d-alpha-tocopherylpoly(ethyleneglycol)1000succinate;D-a-Tocopherol Polyethylene Glycol Succinate (Vitamin E TPGS)
- CBNumber:
- CB8396198
- Molecular Formula:
- (C2H4O)nC33H54O5
- Molecular Weight:
- 0
- MDL Number:
- MFCD00146616
- MOL File:
- 9002-96-4.mol
| Product description | Number | Pack Size | Price |
| D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate | 57668 | 5g | $95.1 |
| D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate | 57668 | 25g | $332 |
| α-Tocopherol Polyethylene Glycol Succinate | T3118 | 5G | $70 |
| α-Tocopherol Polyethylene Glycol Succinate | T3118 | 25G | $240 |
| DL-α-Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) TPGS-750-M | 08-2180 | 50ml | $92 |
| More product size | |||
| Melting point | 34-38°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble1g/10 mL, clear to faintly turbid, colorless to faintly yellow |
| form | Solid |
| color | White to Pale Yellow Waxy |
| biological source | synthetic |
| Water Solubility | H2O: 1g/10 mL, clear to faintly turbid, colorless to faintly yellow |
| InChI | InChI=1S/C34H56O6/c1-23(2)12-9-13-24(3)14-10-15-25(4)16-11-20-34(8)21-19-29-28(7)32(26(5)27(6)33(29)40-34)39-31(37)18-17-30(36)38-22-35/h23-25,35H,9-22H2,1-8H3 |
| InChIKey | WFWQYXBTWIHIIW-UHFFFAOYSA-N |
| SMILES | C(=O)(OC1C(C)=C2CCC(C)(CCCC(CCCC(CCCC(C)C)C)C)OC2=C(C)C=1C)CCC(=O)OCO |
| LogP | 9.745 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | O03S90U1F2 |
| ATC code | A11HA08 |
| NCI Drug Dictionary | tocophersolan |
| UNSPSC Code | 12352205 |
| NACRES | NA.79 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | TR1581200 | |||||||||
| HS Code | 2936.28.0000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Tocofersolan price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 57668 | D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate | 9002-96-4 | 5g | $95.1 | 2025-07-31 | Buy |
| Sigma-Aldrich | 57668 | D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate | 9002-96-4 | 25g | $332 | 2025-07-31 | Buy |
| TCI Chemical | T3118 | α-Tocopherol Polyethylene Glycol Succinate | 9002-96-4 | 5G | $70 | 2025-07-31 | Buy |
| TCI Chemical | T3118 | α-Tocopherol Polyethylene Glycol Succinate | 9002-96-4 | 25G | $240 | 2025-07-31 | Buy |
| Strem Chemicals | 08-2180 | DL-α-Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) TPGS-750-M | 9002-96-4 | 50ml | $92 | 2021-12-16 | Buy |
Tocofersolan Chemical Properties,Uses,Production
Chemical Properties
Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.
Uses
tocophersolan is an anti-oxidant, this is a water-soluble form of vitamin e.
Uses
Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21
Production Methods
Vitamin E polyethylene glycol succinate is prepared by esterification of the acid group of crystalline D-a-tocopheryl acid succinate by polyethylene glycol 1000.
Pharmaceutical Applications
Vitamin E polyethylene glycol succinate is an esterified vitamin E
(tocopherol) derivative primarily used as a solubilizer or emulsifying
agent because of its surfactant properties. Structurally, it is
amphipathic and hydrophilic, unlike the tocopherols, and therefore
it is a water-soluble derivative that can be used in pharmaceutical
formulations such as capsules, tablets, hot-melt extrusion,
microemulsions, topical products, and parenterals. One of
the most important applications is its use as a vehicle for lipid-based
drug delivery formulations. It can also be used as a source of
vitamin E.
Vitamin E polyethylene glycol succinate has been characterized
with respect to its mechanism of action and studied as a Pglycoprotein
inhibitor.
Biochem/physiol Actions
D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) also known as vitamin E TPGS, is a therapeutic agent for vitamin E deficiency in children, administered during chronic childhood cholestasis. TPGS exerts anti-tumor activity in MCF-7 and breast cancer cells by downregulating anti-apoptotic proteins. TPGS finds its application as an emulsifier in the preparation of poly(lactic-co-glycolic acid) (PLGA) particles for DNA labelling, produces particles of uniform size, high encapsulation efficiency, increases hydrophilicity and prevents aggregation of particles.
Safety
Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An additional assessment of the safety of vitamin E polyethylene glycol succinate has been published, which includes a report showing no-observed-adverse-effect-level (NOAEL) in rats of 1000 mg/kg/day.
storage
Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.
Incompatibilities
Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops). Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Tocofersolan Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | 1713330907@QQ.com | China | 2639 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9259 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5241 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20126 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21595 | 55 |
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- Sep 22，2025
View Lastest Price from Tocofersolan manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-03 | Tocofersolan
9002-96-4
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-02-26 | Tocofersolan
9002-96-4
|
US $41.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2026-01-30 | Tocofersolan
9002-96-4
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Tocofersolan
9002-96-4
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Tocofersolan
9002-96-4
- US $41.00 / mg
- TargetMol Chemicals Inc.
-
- Tocofersolan
9002-96-4
- US $1.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
