Fenofibric acid
- CAS No.
- 42017-89-0
- Chemical Name:
- Fenofibric acid
- Synonyms
- FENOFIBRATE ACID;lf153;A-1081;FNF Acid;alpha1081;lf178acid;NSC 281318;EP-B/USP RC B;FENOFIBRIC ACID;FeNAfibric acid
- CBNumber:
- CB8400259
- Molecular Formula:
- C17H15ClO4
- Molecular Weight:
- 318.75
- MDL Number:
- MFCD00792461
- MOL File:
- 42017-89-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Fenofibrate Related Compound B certified reference material, pharmaceutical secondary standard | PHR3315 | 50MG | $592 |
| Fenofibrate impurity B European Pharmacopoeia (EP) Reference Standard | F0048010 | 20 mg | $164 |
| Fenofibric acid 95% | 796565 | 1g | $51.3 |
| Fenofibrate Related Compound B United States Pharmacopeia (USP) Reference Standard | 1269618 | 25mg | $1300 |
| Fenofibric Acid United States Pharmacopeia (USP) Reference Standard | 1269436 | 250mg | $585 |
| More product size | |||
| Melting point | 177-179°C |
|---|---|
| Boiling point | 486.5±35.0 °C(Predicted) |
| Density | 1.286±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 3.09±0.10(Predicted) |
| form | powder |
| color | White to Off-White |
| BRN | 2058973 |
| InChI | InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21) |
| InChIKey | MQOBSOSZFYZQOK-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C(OC1=CC=C(C(=O)C2=CC=C(Cl)C=C2)C=C1)(C)C |
| CAS DataBase Reference | 42017-89-0(CAS DataBase Reference) |
| FDA UNII | BGF9MN2HU1 |
| UNSPSC Code | 77101502 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 36/37/38-50/53-22 | |||||||||
| Safety Statements | 26-36/37/39-61-60-24/25 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UA2453000 | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29189900 | |||||||||
| Toxicity | LD50 oral in rat: 1242mg/kg | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Fenofibric acid price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3315 | Fenofibrate Related Compound B certified reference material, pharmaceutical secondary standard | 42017-89-0 | 50MG | $592 | 2025-07-31 | Buy |
| Sigma-Aldrich | F0048010 | Fenofibrate impurity B European Pharmacopoeia (EP) Reference Standard | 42017-89-0 | 20 mg | $164 | 2025-07-31 | Buy |
| Sigma-Aldrich | 796565 | Fenofibric acid 95% | 42017-89-0 | 1g | $51.3 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1269618 | Fenofibrate Related Compound B United States Pharmacopeia (USP) Reference Standard | 42017-89-0 | 25mg | $1300 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1269436 | Fenofibric Acid United States Pharmacopeia (USP) Reference Standard | 250mg | $585 | 2025-07-31 | Buy |
Fenofibric acid Chemical Properties,Uses,Production
Chemical Properties
Fenofibric acid is a white to almost white crystalline powder that is stable under ordinary conditions and has a melting point of 179 – 183°C. Its empirical formula is C17H15ClO4 and molecular weight 318.75. Fenofibric acid is insoluble in water; its solubility increases with pH in buffered media.
Uses
Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-Iediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptorependent manner
Uses
Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner.
Uses
DPP4 inhibitor, antidiabetic
Definition
ChEBI: A monocarboxylic acid that is 2-methylpropanoic acid substituted by a 4-(4-chlorobenzoyl)phenoxy group at position 2. It is a metabolite of the drug fenofibrate.
Synthesis
![Propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-, phenylmethyl ester](/CAS/20210305/GIF/1159999-13-9.gif)
1159999-13-9
42017-89-0
General procedure for the synthesis of fenofibric acid from compound (CAS:1159999-13-9): to a solution of compound 104 (5.00 g, 12.2 mmol) in ethanol (150 mL) was added a solution of potassium hydroxide (2.74 g, 48.9 mmol) in ethanol (50 mL). The reaction mixture was heated to reflux and stirred for 16 hours. Upon completion of the reaction, ethanol was removed under vacuum and water (200 mL) was added to the residue. The aqueous solution was washed with ether (2 x 100 mL) to remove nonpolar impurities, followed by acidification of the aqueous solution with 2N HCl to pH 1. The acidified aqueous solution was extracted with ethyl acetate (2 x 150 mL), the organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum to give compound 105 (3.57 g, 91% yield) as an off-white solid . The product was characterized by 1H NMR (300 MHz, CD3OD): δ 7.75-7.70 (m, 4H), 7.52 (d, J = 8.6 Hz, 2H), 6.96 (d, J = 9.0 Hz, 2H), 1.65 (s, 6H).
Metabolism
Fenofibric acid is primarily conjugated with glucuronic acid and then excreted in urine. A small amount of fenofibric acid is reduced at the carbonyl moiety to a benzhydrol metabolite, which is, in turn, conjugated with glucuronic acid and excreted in urine. In vitro and in vivo metabolism data indicate that fenofibric acid does not undergo oxidative metabolism (e.g. cytochrome P450) to a significant extent. The enzymes CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 do not play a role in the metabolism of fenofibric acid.
References
[1] Patent: WO2009/73138, 2009, A2. Location in patent: Page/Page column 81-82
Fenofibric acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qingdao Yonghefeng Economic and Trade Co., Ltd. | +86-13375559818 | cfy69@163.com | China | 195 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8772 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 | sales@sjar-tech.com | China | 504 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1001 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
View Lastest Price from Fenofibric acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-18 | Fenofibric acid
42017-89-0
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-10-17 | Fenofibric acid
42017-89-0
|
US $29.00 / mL | 99.94% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-10-17 | Fenofibric acid
42017-89-0
|
US $29.00 / mL | 99.94% | 10g | TargetMol Chemicals Inc. |
-
- Fenofibric acid
42017-89-0
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Fenofibric acid
42017-89-0
- US $29.00 / mL
- 99.94%
- TargetMol Chemicals Inc.
-
- Fenofibric acid
42017-89-0
- US $29.00 / mL
- 99.94%
- TargetMol Chemicals Inc.
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