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2-Hydroxy-5-nitropyridine

2-Hydroxy-5-nitropyridine structure

CAS No.: 5418-51-9

Chemical Name:: 2-Hydroxy-5-nitropyridine

Synonyms: 5-Nitro-2-pyridol;5-Nitro-2-pyridone;5-NITRO-2-PYRIDINOL;5-Nirto-2-pyridinol;TIMTEC-BB SBB004167;5-Nitro-2-pyridinone;Hydroxy-5-nitropyrid;2-Pyridinol, 5-nitro-;5-(NITRO)PYRIDIN-2-OL;5-Nitro-2(1H)-pyridone

CBNumber:: CB8401933

Molecular Formula:: C5H4N2O3

Molecular Weight:: 140.1

MDL Number:: MFCD00006276

MOL File:: 5418-51-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:27:06

Product description	Number	Pack Size	Price
2-Hydroxy-5-nitropyridine 97%	H48808	25g	$87.7
2-Hydroxy-5-nitropyridine 97%	H48808	100g	$248
2-Hydroxy-5-nitropyridine >97.0%(GC)(T)	H0673	25g	$116
2-Hydroxy-5-nitropyridine >97.0%(GC)(T)	H0673	250g	$819
5-Nitropyridin-2(1H)-one	N900625	5g	$55
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2-Hydroxy-5-nitropyridine Properties

Melting point	188-191 °C (lit.)
Boiling point	256.56°C (rough estimate)
Density	1.5657 (rough estimate)
refractive index	1.4800 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Very Slightly)
pka	8.06±0.10(Predicted)
form	Crystalline Powder
color	Light yellow to beige
Water Solubility	Soluble in hot water and alkali liquor, Insoluble in most of organic solvents.
BRN	120352
InChI	InChI=1S/C5H4N2O3/c8-5-2-1-4(3-6-5)7(9)10/h1-3H,(H,6,8)
InChIKey	XKWSQIMYNVLGBO-UHFFFAOYSA-N
SMILES	C1(=O)NC=C([N+]([O-])=O)C=C1
CAS DataBase Reference	5418-51-9(CAS DataBase Reference)
FDA UNII	H3L3D7HP42
NIST Chemistry Reference	2-Hydroxy-5-nitropyridine(5418-51-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39-36

WGK Germany

HazardClass

IRRITANT

HS Code

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
1		0

2-Hydroxy-5-nitropyridine price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H48808	2-Hydroxy-5-nitropyridine 97%	5418-51-9	25g	$87.7	2026-03-19	Buy
Sigma-Aldrich	H48808	2-Hydroxy-5-nitropyridine 97%	5418-51-9	100g	$248	2026-03-19	Buy
TCI Chemical	H0673	2-Hydroxy-5-nitropyridine >97.0%(GC)(T)	5418-51-9	25g	$116	2026-03-19	Buy
TCI Chemical	H0673	2-Hydroxy-5-nitropyridine >97.0%(GC)(T)	5418-51-9	250g	$819	2021-12-16	Buy
TRC	N900625	5-Nitropyridin-2(1H)-one	5418-51-9	5g	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
H48808	25g	$87.7	Buy
H48808	100g	$248	Buy
H0673	25g	$116	Buy
H0673	250g	$819	Buy
N900625	5g	$55	Buy

2-Hydroxy-5-nitropyridine Chemical Properties,Uses,Production

Chemical Properties

light yellow to beige crystalline powder

Uses

A comparison of catalysts promotes imidazolide couplings including the identification of 2-hydroxy-5-nitropyridine as a new, safe, and effective catalyst.

Synthesis

4214-76-0

5418-51-9

General procedure for the synthesis of 2-hydroxy-5-nitropyridine from 2-amino-5-nitropyridine: 2-amino-5-nitropyridine (13.9 g, 0.1 mol) was dissolved in 55.6 g of 15% dilute hydrochloric acid, and 44.85 g of 20% aqueous sodium nitrite (NaNO2) was added slowly dropwise. After the dropwise addition, the reaction was continued for 6 hours. The reaction temperature was maintained at 40°C for 40 minutes. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and a light yellow solid was precipitated after cooling. The solid was washed with ice water and dried to obtain 2-hydroxy-5-nitropyridine (12.61 g), which was analyzed by high performance liquid chromatography (HPLC) with a purity of 97.69% and a yield of 88.02%.

References

[1] Patent: CN105523995, 2016, A. Location in patent: Paragraph 0026; 0047; 0048
[2] Chemistry of Heterocyclic Compounds, 2002, vol. 38, # 7, p. 805 - 809
[3] Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 10, p. 3597 - 3602
[4] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1914, vol. 46, p. 1240
[5] Chem. Zentralbl., 1915, vol. 86, # I, p. 1066

2-Hydroxy-5-nitropyridine Preparation Products And Raw materials

Raw materials

2-Aminopyridine 2-Amino-5-nitropyridine Sodium nitrite Hydrochloric acid

Preparation Products

5-Amino-2,3-dichloropyridine 3,5-DIAMINOPYRIDINE 3-Chloro-2-hydroxy-5-nitropyridine 5-Amino-3-bromo-2-methoxypyridine 2,3-DICHLORO-5-NITROPYRIDINE

5-ACETAMIDO-2-BROMOPYRIDINE 7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE 2-Bromo-5-nitropyridine 2-CHLORO-3,5-DINITROPYRIDINE 5-Amino-2-bromopyridine

2-Chloro-5-nitropyridine 2-Amino-5-nitropyridine 5-Amino-2-hydroxypyridine 5-AMINO-3-BROMO-2-METHYLPYRIDINE

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2-Hydroxy-5-nitropyridine Suppliers

Global( 525)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8743	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20125	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 2-Hydroxy-5-nitropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	2-Hydroxy-5-nitropyridine 5418-51-9	US $0.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-11-18	2-Hydroxy-5-nitropyridine 5418-51-9	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-09-25	5-Nitropyridin-2-ol 5418-51-9	US $6.00-0.90 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

2-Hydroxy-5-nitropyridine
5418-51-9
US $0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Hydroxy-5-nitropyridine
5418-51-9
US $1.10 / g
99.00%
Dideu Industries Group Limited

5-Nitropyridin-2-ol
5418-51-9
US $6.00-0.90 / KG
99%
Henan Fengda Chemical Co., Ltd

2-Hydroxy-5-nitropyridine Spectrum

2-Hydroxy-5-nitropyridine(5418-51-9)MS 2-Hydroxy-5-nitropyridine(5418-51-9)¹HNMR 2-Hydroxy-5-nitropyridine(5418-51-9)IR1 2-Hydroxy-5-nitropyridine(5418-51-9)IR2 2-Hydroxy-5-nitropyridine(5418-51-9)Raman

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2-HYDROXY-5-NITROPYRIDINE 5-(NITRO)PYRIDIN-2-OL 5-NITRO-2-PYRIDINOL 2(1H)-Pyridinone, 5-nitro- 2-Pyridinol, 5-nitro- 5-Nirto-2-pyridinol 5-Nitro-2(1H)-pyridone 5-Nitro-2-hydroxypyridine 5-Nitro-2-pyridinone 5-Nitro-2-pyridol 5-Nitro-2-pyridone TIMTEC-BB SBB004167 2-Hydroxy-5-nitropyridine, 98+% 2-Hydroxy-5-nitropyridine, 99+% 2-Hydoxy-5-nitropyridine 2(1H)-Pyridinone,5-nitro-(9CI) 5-nitropyridin-2(1H)-one 5-Nitro-1,2-dihydropyridine-2-one 5-Nitro-1H-pyridin-2-one Hydroxy-5-nitropyrid 2-Hydroxy-5-nitropyridine 97% 2-Hydroxy-5-nitropyridine> 2-Hydroxy-5-nitropyridine ISO 9001：2015 REACH 2-Hydroxy-5-nitropyridine, 95% 5418-51-9 5418-15-9 C5H4N203 Heterocyclic Building Blocks Pyridines AMINO Building Blocks C5 Building Blocks C5 Chemical Synthesis Heterocyclic Building Blocks Pyridines, Pyrimidines, Purines and Pteredines Pyridines derivates blocks Pyridines Pyridine Pyridine Series alcohol| nitro-compound NITRO bc0001 1