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(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER structure

CAS No.: 309915-46-6

Chemical Name:: (2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Synonyms: (2R,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate;Felbinac Impurity 25;(2R,5S)-1-N-Boc-2,5-dimethylpiperazine;(2R,5S-TERT-BUTYL 2,5-DIMETHYLPIPERAZINE;(2R,5S)-Tert-Butyl 2,5-Dimethylpiperazine;(2R,5S)-2,5-Dimethylpiperazine, N1-Boc protected;TERT-BUTYL(2R,5S)-2,5-DIMETHYLPIPERAZINE-1-CARBOXYLATE;2,5-DiMethyl-piperazine-1-carboxylic acid tert-butyl ester;(2R,5S)-N-(tert-butyl)-2,5-dimethyl-1-piperazinecarboxamide;(2R,5S)- tert - Butyl 2,5- dimethylpiperazine -- I - carboxylate

CBNumber:: CB8410616

Molecular Formula:: C11H22N2O2

Molecular Weight:: 214.3

MDL Number:: MFCD06797728

MOL File:: Mol file

MSDS File:: SDS

Last updated:2026-05-28 05:02:51

Product description	Number	Pack Size	Price
(2R,5S)-1-BOC-2,5-DIMETHYLPIPERAZINE 97%	55645	5G	$33
(2R,5S)-1-BOC-2,5-DIMETHYLPIPERAZINE 97%	55645	25G	$107
(2R,5S)-1-BOC-2,5-DIMETHYLPIPERAZINE 97%	55645	100G	$477
(2R,5S)-2,5-Dimethylpiperazine-1-carboxylic acid tert-butyl ester	207277	1.00g	$905
tert-butyl (2R,5S)-2,5-dimethylpiperazine-1-carboxylate 97+%	D31865	1g	$20

Request For Quotation

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Properties

Boiling point	280℃
Density	0.970
Flash point	123℃
storage temp.	2-8°C(protect from light)
pka	8.55±0.60(Predicted)
form	solid
color	Colourless to light yellow / liquid
InChI	InChI=1S/C11H22N2O2/c1-8-7-13(9(2)6-12-8)10(14)15-11(3,4)5/h8-9,12H,6-7H2,1-5H3/t8-,9+/m0/s1
InChIKey	PGZCVLUQTJRRAA-DTWKUNHWSA-N
SMILES	N1(C(OC(C)(C)C)=O)C[C@H](C)NC[C@H]1C

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P260-P280-P301+P312
HS Code	2933599590

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	55645	(2R,5S)-1-BOC-2,5-DIMETHYLPIPERAZINE 97%	309915-46-6	5G	$33	2026-04-30	Buy
AstaTech	55645	(2R,5S)-1-BOC-2,5-DIMETHYLPIPERAZINE 97%	309915-46-6	25G	$107	2026-04-30	Buy
AstaTech	55645	(2R,5S)-1-BOC-2,5-DIMETHYLPIPERAZINE 97%	309915-46-6	100G	$477	2026-04-30	Buy
Matrix Scientific	207277	(2R,5S)-2,5-Dimethylpiperazine-1-carboxylic acid tert-butyl ester	309915-46-6	1.00g	$905	2026-05-18	Buy
Synthonix	D31865	tert-butyl (2R,5S)-2,5-dimethylpiperazine-1-carboxylate 97+%	309915-46-6	1g	$20	2026-05-06	Buy

Product number	Packaging	Price	Buy
55645	5G	$33	Buy
55645	25G	$107	Buy
55645	100G	$477	Buy
207277	1.00g	$905	Buy
D31865	1g	$20	Buy

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production

Uses

As an organic intermediate, (2R,5S)-2,5-DiMethyl-piperazine-1-carboxylic acid tert-butyl ester is mainly used in organic synthesis and scientific research.

Synthesis

1-Piperazinecarboxylic acid, 4-[(4-fluorophenyl)methyl]-2,5-dimethyl-, 1,1-dimethylethyl ester, (2R,5S)-

431062-01-0

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

309915-46-6

Tert-butyl 4-(4-fluorobenzyl)-(2R,5S)-dimethylpiperazine-1-carboxylate (37.8 g, 117.4 mmol) was used as a raw material and dissolved in a mixture of methanol (250 mL) and glacial acetic acid (30 mL). The mixture was transferred to a 2 L hydrogenation flask, purged with nitrogen and stirred for 10 min. Subsequently, palladium hydroxide (3.8 g, 20 wt%) was added to the mixture and the reaction was shaken at room temperature and 40 psi hydrogen pressure for 48 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and washed with methanol. The filtrate was concentrated to dryness on a rotary evaporator to afford 37.64 g (100% yield) of the target product (2R,5S)-tert-butyl (2R,5-Dimethylpiperazine-1-carboxylate), which was detected by mass spectrometry showing the M+H+ peak at 215.

References

[1] Patent: US2004/142940, 2004, A1. Location in patent: Page/Page column 29
[2] Patent: US2004/142940, 2004, A1. Location in patent: Page/Page column 44-45
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 828 - 831

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

(2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-[(4-fluorophenyl)methyl]-2,5-dimethyl-, 1,1-dimethylethyl ester, (2R,5S)- Methanol Hydrogen Acetic acid

Preparation Products

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

Global( 123)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Joy Biotech Ltd.	+86-15968534750 +86-1358845959750	sales@joybiotech.com	China	991	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Jinan Liheng Biotechnology Co., Ltd.	15865262812	info@lihengpharm.com	CHINA	938	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14304	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
Shanghai Joy Biotech Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
career henan chemical co	58
Jinan Liheng Biotechnology Co., Ltd.	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Win-Win chemical CO., Limited	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from (2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-03-12	(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 309915-46-6		1kg	99%	20tons	Shanghai Joy Biotech Ltd.
	2020-01-13	2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 309915-46-6	$5.00	1KG	98%	100KG	Career Henan Chemical Co

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
309915-46-6
99%
Shanghai Joy Biotech Ltd.

2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
309915-46-6
$5.00
98%
Career Henan Chemical Co

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Spectrum

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(309915-46-6)¹HNMR

309915-46-6((2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER)Related Search:

(2R,5R)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (2S,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (2S,5R)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL(2R,5S)-2,5-DIMETHYLPIPERAZINE-1-CARBOXYLATE 2,5-DiMethyl-piperazine-1-carboxylic acid tert-butyl ester (2R,5S)-N-(tert-butyl)-2,5-dimethyl-1-piperazinecarboxamide (2R,5S)-1-N-Boc-2,5-dimethylpiperazine (2R,5S)-N-(1,1-Dimethylethyl)-2,5-dimethyl-1-piperazinecarboxamide (2R,5S)-Tert-Butyl 2,5-Dimethylpiperazine (2R,5S-TERT-BUTYL 2,5-DIMETHYLPIPERAZINE (2R,5S)-2,5-Dimethylpiperazine, N1-Boc protected 1-Piperazinecarboxylic acid, 2,5-dimethyl-, 1,1-dimethylethyl ester, (2R,5S)- (2R,5S)- tert - Butyl 2,5- dimethylpiperazine -- I - carboxylate Felbinac Impurity 25 tert-butyl (2R,5S)-2,5-dimethylpiperazine-1-carboxylate - [D31865] (2R,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate 309915-46-6