BMS-852927
- CAS No.
- 1256918-39-4
- Chemical Name:
- BMS-852927
- Synonyms
- XL041;XL-041);BMS-852927;XL041,XL-041;XL041（BMS-852927）;BMS-852927 (BMS 852927;2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3'-difluoro-4'-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol;1H-Imidazole-4-methanol, 2-[1-(2,6-dichlorophenyl)-1-methylethyl]-1-[3,3'-difluoro-4'-(hydroxymethyl)-5'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-α,α-dimethyl-
- CBNumber:
- CB84187952
- Molecular Formula:
- C29H28Cl2F2N2O4S
- Molecular Weight:
- 609.51
- MDL Number:
- MFCD31618069
- MOL File:
- 1256918-39-4.mol
| Boiling point | 810.6±75.0 °C(Predicted) |
|---|---|
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 150 mg/mL (246.10 mM) |
| form | Solid |
| pka | 11.20±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | H9649L8MZN |
BMS-852927 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-7926 | XL041 99.44% | 1256918-39-4 | 1mg | $132 | 2021-12-16 | Buy |
| ChemScene | CS-7926 | XL041 99.44% | 1256918-39-4 | 5mg | $396 | 2021-12-16 | Buy |
| ChemScene | CS-7926 | XL041 99.44% | 1256918-39-4 | 10mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-7926 | XL041 99.44% | 1256918-39-4 | 50mg | $1800 | 2021-12-16 | Buy |
| ChemScene | CS-7926 | XL041 99.44% | 1256918-39-4 | 100mg | $2520 | 2021-12-16 | Buy |
BMS-852927 Chemical Properties,Uses,Production
Uses
XL041 (BMS-852927) is an LXRβ-selective agonist.
in vivo
XL041 (BMS-852927), has a very favorable profile at efficacious doses in cynomolgus monkeys and mice. XL041 pre-treatment of C57BL/6J mice for 7 days results in potent, dose-dependent stimulation of cholesterol efflux in this system, reaching a maximum in the 3 mg/kg/day dose group of 70% above vehicle in the initial efflux rate. Similar results are obtained in LDLR knockout (KO) mice. In a separate study, XL041 inhibits the progression of atherosclerosis in a 12 week study in LDLR KO mice. Importantly, the dose response for inhibition of atherosclerosis (0.1-3 mg/kg/day) is similar to the dose response for macrophage reverse cholesterol transport (RCT) stimulation (0.03-3 mg/kg/day), a major underlying mechanism through which LXR agonists affect the disease[1].
References
[1] Kirchgessner TG, et al. Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils. Cell Metab. 2016 Aug 9;24(2):223-33. DOI:10.1016/j.cmet.2016.07.016
BMS-852927 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS-852927 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Chongqing jooe co., ltd | +86-19923400328 +86-15223382610 | info@jooe.com | China | 5617 | 58 |
| Wuhan HengHeDa Pharm Co., Ltd. | 027-84888681 18086046872 | hhdpharm@hotmail.com | China | 106 | 55 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7781 | 56 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1788 | 58 |
| Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1886 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
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