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DEHYDROXYMETHYLEPOXYQUINOMICIN

DEHYDROXYMETHYLEPOXYQUINOMICIN structure

CAS No.: 287194-40-5

Chemical Name:: DEHYDROXYMETHYLEPOXYQUINOMICIN

Synonyms: DHMEQ;DHM2EQ;()DHMEQ,( ) DHMEQ;DEHYDROXYMETHYLEPOXYQUINOMICIN;Dehydroxymethylepoxyquinomicin (DHMEQ);(-)-DHMEQ?(dehydroxymethylepoxyquinomicin);2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzaMide;Benzamide, 2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-;2-hydroxy-N-[(1aS,2S,5aS)-2-hydroxy-5-oxo-1a,2,5,5a-tetrahydrocyclohexa[1,2-b]oxiren-3-yl]benzamide

CBNumber:: CB8419477

Molecular Formula:: C13H11NO5

Molecular Weight:: 261.23

MDL Number:: MFCD11100254

MOL File:: 287194-40-5.mol

Last updated:2025-04-18 09:52:54

Product description	Number	Pack Size	Price
(-)-DHMEQ 98.83%	CS-5488	2mg	$168
(-)-DHMEQ 98.83%	CS-5488	5mg	$264
(-)-DHMEQ 98.83%	CS-5488	10mg	$360
DHMEQ 95.00%	INB0001467	5MG	$496.86
(-)-DHMEQ 98.83%	CS-5488	25mg	$720

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DEHYDROXYMETHYLEPOXYQUINOMICIN Properties

Melting point	187 °C
Boiling point	617.2±55.0 °C(Predicted)
Density	1.58±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : ≥ 32 mg/mL (122.50 mM)
pka	8.43±0.30(Predicted)
form	Solid
color	Off-white to gray

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

DEHYDROXYMETHYLEPOXYQUINOMICIN price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-5488	(-)-DHMEQ 98.83%	287194-40-5	2mg	$168	2021-12-16	Buy
ChemScene	CS-5488	(-)-DHMEQ 98.83%	287194-40-5	5mg	$264	2021-12-16	Buy
ChemScene	CS-5488	(-)-DHMEQ 98.83%	287194-40-5	10mg	$360	2021-12-16	Buy
American Custom Chemicals Corporation	INB0001467	DHMEQ 95.00%	287194-40-5	5MG	$496.86	2021-12-16	Buy
ChemScene	CS-5488	(-)-DHMEQ 98.83%	287194-40-5	25mg	$720	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-5488	2mg	$168	Buy
CS-5488	5mg	$264	Buy
CS-5488	10mg	$360	Buy
INB0001467	5MG	$496.86	Buy
CS-5488	25mg	$720	Buy

DEHYDROXYMETHYLEPOXYQUINOMICIN Chemical Properties,Uses,Production

Uses

(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity[1][2][3].

in vivo

(-)-DHMEQ (4 mg/kg or 12 mg/kg; intraperitoneal injection; on day 0 and 3 times a week; for one month; SCID mice) treatment shows a significant increase in the survival rate in mice^[2].

Animal Model:	Male C.B17-scid/scid (5 weeks old) mice injected with MT-2 cells^[2]
Dosage:	4 mg/kg or 12 mg/kg
Administration:	Intraperitoneal injection; on day 0 and 3 times a week; for one month
Result:	Showed a significant increase in the survival rate in mice.

IC 50

RelA; RelB

References

[1] Yinzhi Lin, et al. Inhibition of Late and Early Phases of Cancer Metastasis by the NF-κB Inhibitor DHMEQ Derived from Microbial Bioactive Metabolite Epoxyquinomicin: A Review. DOI:10.3390/ijms19030729
[2] Mariko Watanabe, et al. Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia. Blood. 2005 Oct 1;106(7):2462-71. DOI:10.1182/blood-2004-09-3646
[3] Quach HT, et al. Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor κB Subunit RelB in Response to a Lymphotoxin β Stimulation. Biol Pharm Bull. 2017;40(10):1669-1677. DOI:10.1248/bpb.b17-00170

DEHYDROXYMETHYLEPOXYQUINOMICIN Preparation Products And Raw materials

Raw materials

Preparation Products

DEHYDROXYMETHYLEPOXYQUINOMICIN Suppliers

Global( 31)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32434	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43339	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3767	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Chembest Research Laboratories Limited	+86-21-20908456	sales@BioChemBest.com	China	6003	61
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7552	61
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3504	58
Shanghai HuanChuan Industry Co.,Ltd.	021-61478794	sales@hcshhai.com	China	9793	50

Supplier	Advantage
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
HANGZHOU LEAP CHEM CO., LTD.	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Chembest Research Laboratories Limited	61
Haoyuan Chemexpress Co., Ltd.	61
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai HuanChuan Industry Co.,Ltd.	50

2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzaMide Dehydroxymethylepoxyquinomicin (DHMEQ) DEHYDROXYMETHYLEPOXYQUINOMICIN DHM2EQ DHMEQ Benzamide, 2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]- (-)-DHMEQ?(dehydroxymethylepoxyquinomicin) ()DHMEQ,( ) DHMEQ 2-hydroxy-N-[(1aS,2S,5aS)-2-hydroxy-5-oxo-1a,2,5,5a-tetrahydrocyclohexa[1,2-b]oxiren-3-yl]benzamide 287194-40-5