5-(3-Chlorophenyl)-3-hydroxypicolinic acid
- CAS No.
- 1415226-40-2
- Chemical Name:
- 5-(3-Chlorophenyl)-3-hydroxypicolinic acid
- Synonyms
- 5-(3-Chlorophenyl)-3-hydroxypicolinic acid;5-(3-Chlorophenyl)-3-hydroxy-2-pyridinecarboxylic acid;5-(3-chlorophenyl)-3-hydroxypyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 5-(3-chlorophenyl)-3-hydroxy-
- CBNumber:
- CB84196589
- Molecular Formula:
- C12H8ClNO3
- Molecular Weight:
- 249.65
- MDL Number:
- MFCD30802547
- MOL File:
- 1415226-40-2.mol
| Boiling point | 543.3±50.0 °C(Predicted) |
|---|---|
| Density | 1.461±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 1.01±0.50(Predicted) |
| InChI | InChI=1S/C12H8ClNO3/c13-9-3-1-2-7(4-9)8-5-10(15)11(12(16)17)14-6-8/h1-6,15H,(H,16,17) |
| InChIKey | KMZAXKDGIXGPOF-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)=NC=C(C2=CC=CC(Cl)=C2)C=C1O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| REACH Registrations | Active |
5-(3-Chlorophenyl)-3-hydroxypicolinic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 307146 | 5-(3-Chlorophenyl)-3-hydroxypicolinic acid | 1415226-40-2 | 100.00mg | $104 | 2026-05-19 | Buy |
| Matrix Scientific | 307146 | 5-(3-Chlorophenyl)-3-hydroxypicolinic acid | 1415226-40-2 | 250.00mg | $154 | 2026-05-19 | Buy |
| Matrix Scientific | 307146 | 5-(3-Chlorophenyl)-3-hydroxypicolinic acid | 1415226-40-2 | 1.00g | $291 | 2026-05-19 | Buy |
| Synthonix | C56457 | 5-(3-Chlorophenyl)-3-hydroxypicolinic acid 97% | 1415226-40-2 | 100mg | $230 | 2026-05-06 | Buy |
| Synthonix | C56457 | 5-(3-Chlorophenyl)-3-hydroxypicolinic acid 97% | 1415226-40-2 | 250mg | $330 | 2026-05-06 | Buy |
5-(3-Chlorophenyl)-3-hydroxypicolinic acid Chemical Properties, Uses, Production
Uses
5-(3-Chlorophenyl)-3-hydroxy-2-pyridinecarboxylic Acid can be used for hydroxylase enzyme inhibitors.
Synthesis
1415226-39-9
1415226-40-2
The general procedure for the synthesis of 5-(3-chlorophenyl)-3-methoxypicolinonitrile as a raw material for 5-(3-chlorophenyl)-3-hydroxypyridine carboxylic acid was as follows: to a 20 L reactor equipped with a mechanical stirrer, condenser tube, thermometer and nitrogen inlet was added 5-(3-chlorophenyl)-3-methoxy-2-cyano-pyridine (440.6 g, 1.8 mol) and 37% hydrochloric acid aqueous solution (5302g). The reaction mixture was heated to 102 °C under stirring and maintained for 24 hours. Subsequently, 37% aqueous hydrochloric acid solution (2653 g) was added and stirring was continued at 104 °C for 18 hours. After completion of the reaction, the mixture was cooled to 5 °C, water (4410 g) was added and stirred at 0 °C for 16 hours. The precipitated product was separated by filtration and washed with water until the filtrate had a pH of 6 (about 8000 L of water was consumed). The filter cake was dried under reduced pressure for 2 hours. Afterwards, the filter cake was retransferred to a reactor and ground with THF (1958 g, 2201 mL) for 2 hours at room temperature. The solid product was again separated by filtration and washed with THF (778 g, 875 mL), and finally dried under reduced pressure for 48 h at 5 °C to give an off-white solid product of 385 g (89% yield). HPLC analysis showed the product purity to be 96.2%.1H NMR (DMSO-d6) data were as follows: δ 8.52 (d, 1H), 7.99 (d, 1H) 7.95 (s, 1H), 7.81 (t, 1H), 7.57 (s, 1H), 7.55 (s, 1H).
References
[1] Patent: US2012/309977, 2012, A1. Location in patent: Page/Page column 20-21
[2] Patent: WO2016/153996, 2016, A1. Location in patent: Paragraph 00130
5-(3-Chlorophenyl)-3-hydroxypicolinic acid Preparation Products And Raw materials
5-(3-Chlorophenyl)-3-hydroxypicolinic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Keepontech Co.,Ltd | 021-54849683 13601642561 | sales@keepontech.com | China | 998 | 59 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| Hangzhou Cheminspire Technology Co., Ltd. | 0571-89081561; 10006559855 | info@cheminspire.com | China | 412 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Shanghai ring qi biological technology co., LTD | 13524106587 | sales@hq-chem.com | China | 242 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
| Labnetwork lnc. | +86-27-50766799 +86-18062016861 | contact@labnetwork.com | China | 19981 | 58 |
| Jinan Ruisi Pharmaceutical Technology Co., LTD | 0531-0531-69900633 19963472814 | changyuan20@163.com | China | 9938 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
View Latest Price from 5-(3-Chlorophenyl)-3-hydroxypicolinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | 5-(3-chlorophenyl)-3-hydroxypicolinic acid | 1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. |
-
- 5-(3-chlorophenyl)-3-hydroxypicolinic acid
- 99%
- Jinan Ruitong Biotech Co., Ltd.
