5-(3-Chlorophenyl)-3-hydroxypicolinic acid
- CAS No.
- 1415226-40-2
- Chemical Name:
- 5-(3-Chlorophenyl)-3-hydroxypicolinic acid
- Synonyms
- 5-(3-Chlorophenyl)-3-hydroxypicolinic acid;5-(3-Chlorophenyl)-3-hydroxy-2-pyridinecarboxylic acid;5-(3-chlorophenyl)-3-hydroxypyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 5-(3-chlorophenyl)-3-hydroxy-
- CBNumber:
- CB84196589
- Molecular Formula:
- C12H8ClNO3
- Molecular Weight:
- 249.65
- MDL Number:
- MFCD30802547
- MOL File:
- 1415226-40-2.mol
| Product description | Number | Pack Size | Price |
| 5-(3-Chlorophenyl)-3-hydroxypyridine-2-carboxylicacid | 3368DT | 10g | $1518 |
| 5-(3-Chlorophenyl)-3-hydroxypicolinicacid 97% | CM249306 | 10g | $1636 |
| 5-(3-Chlorophenyl)-3-hydroxypicolinicacid 97% | A261647 | 100mg | $89 |
| 5-(3-Chlorophenyl)-3-hydroxypicolinicacid 97% | A261647 | 250mg | $134 |
| 5-(3-Chlorophenyl)-3-hydroxypicolinicacid 97% | A261647 | 1g | $261 |
| Boiling point | 543.3±50.0 °C(Predicted) |
|---|---|
| Density | 1.461±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 1.01±0.50(Predicted) |
| InChI | InChI=1S/C12H8ClNO3/c13-9-3-1-2-7(4-9)8-5-10(15)11(12(16)17)14-6-8/h1-6,15H,(H,16,17) |
| InChIKey | KMZAXKDGIXGPOF-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)=NC=C(C2=CC=CC(Cl)=C2)C=C1O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5-(3-Chlorophenyl)-3-hydroxypicolinic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 3368DT | 5-(3-Chlorophenyl)-3-hydroxypyridine-2-carboxylicacid | 1415226-40-2 | 10g | $1518 | 2021-12-16 | Buy |
| Chemenu | CM249306 | 5-(3-Chlorophenyl)-3-hydroxypicolinicacid 97% | 1415226-40-2 | 10g | $1636 | 2021-12-16 | Buy |
| Ambeed | A261647 | 5-(3-Chlorophenyl)-3-hydroxypicolinicacid 97% | 1415226-40-2 | 100mg | $89 | 2021-12-16 | Buy |
| Ambeed | A261647 | 5-(3-Chlorophenyl)-3-hydroxypicolinicacid 97% | 1415226-40-2 | 250mg | $134 | 2021-12-16 | Buy |
| Ambeed | A261647 | 5-(3-Chlorophenyl)-3-hydroxypicolinicacid 97% | 1415226-40-2 | 1g | $261 | 2021-12-16 | Buy |
5-(3-Chlorophenyl)-3-hydroxypicolinic acid Chemical Properties,Uses,Production
Uses
5-(3-Chlorophenyl)-3-hydroxy-2-pyridinecarboxylic Acid can be used for hydroxylase enzyme inhibitors.
Synthesis
1415226-39-9
1415226-40-2
The general procedure for the synthesis of 5-(3-chlorophenyl)-3-methoxypicolinonitrile as a raw material for 5-(3-chlorophenyl)-3-hydroxypyridine carboxylic acid was as follows: to a 20 L reactor equipped with a mechanical stirrer, condenser tube, thermometer and nitrogen inlet was added 5-(3-chlorophenyl)-3-methoxy-2-cyano-pyridine (440.6 g, 1.8 mol) and 37% hydrochloric acid aqueous solution (5302g). The reaction mixture was heated to 102 °C under stirring and maintained for 24 hours. Subsequently, 37% aqueous hydrochloric acid solution (2653 g) was added and stirring was continued at 104 °C for 18 hours. After completion of the reaction, the mixture was cooled to 5 °C, water (4410 g) was added and stirred at 0 °C for 16 hours. The precipitated product was separated by filtration and washed with water until the filtrate had a pH of 6 (about 8000 L of water was consumed). The filter cake was dried under reduced pressure for 2 hours. Afterwards, the filter cake was retransferred to a reactor and ground with THF (1958 g, 2201 mL) for 2 hours at room temperature. The solid product was again separated by filtration and washed with THF (778 g, 875 mL), and finally dried under reduced pressure for 48 h at 5 °C to give an off-white solid product of 385 g (89% yield). HPLC analysis showed the product purity to be 96.2%.1H NMR (DMSO-d6) data were as follows: δ 8.52 (d, 1H), 7.99 (d, 1H) 7.95 (s, 1H), 7.81 (t, 1H), 7.57 (s, 1H), 7.55 (s, 1H).
References
[1] Patent: US2012/309977, 2012, A1. Location in patent: Page/Page column 20-21
[2] Patent: WO2016/153996, 2016, A1. Location in patent: Paragraph 00130
5-(3-Chlorophenyl)-3-hydroxypicolinic acid Preparation Products And Raw materials
5-(3-Chlorophenyl)-3-hydroxypicolinic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co., Ltd. | +undefined17612118332 | Lucky@hanhonggroup.com | China | 5844 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14359 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43416 | 58 |
| Beijing Toachem Chemical Co.,Ltd | +8618311365218 | sales@toachem.com | China | 217 | 58 |
| Jinan Ruitong Biotech Co., Ltd. | +86-16615778970 +86-16615778970 | info@ritonbio.com | China | 511 | 58 |
| Shanghai Keepontech Co.,Ltd | 021-54849683 13601642561 | sales@keepontech.com | China | 1005 | 59 |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 42446 | 60 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5677 | 50 |
| Hangzhou Cheminspire Technology Co., Ltd. | 0571-89081561; 10006559855 | info@cheminspire.com | China | 412 | 58 |
View Lastest Price from 5-(3-Chlorophenyl)-3-hydroxypicolinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-08-22 | 5-(3-chlorophenyl)-3-hydroxypicolinic acid | US $0.00-0.00 / kg | 1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. |
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- 5-(3-chlorophenyl)-3-hydroxypicolinic acid
- US $0.00-0.00 / kg
- 99%
- Jinan Ruitong Biotech Co., Ltd.
