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Tetrahydrothiophen-3-one

Tetrahydrothiophen-3-one structure

CAS No.: 1003-04-9

Chemical Name:: Tetrahydrothiophen-3-one

Synonyms: dihydrothiophen-3(2h)-one;4,5-DIHYDRO-3(2H)-THIOPHENONE;Dihydro-3-(2H)-thiophenone;FEMA 3266;TETRAHYDROTHIOPHENE-3-ONE;Tetrahydro-thienone;3(2H)-dihydrothiophenone;4,5-Dihydrothiophen-3(2H)-one;3-thiolanone;3-THIOPHANONE

CBNumber:: CB8423034

Molecular Formula:: C4H6OS

Molecular Weight:: 102.15

MDL Number:: MFCD00005412

MOL File:: 1003-04-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:12:56

Product description	Number	Pack Size	Price
4,5-Dihydro-3(2H)-thiophenone ≥98%, FG	W326607	1 each	$58
4,5-Dihydro-3(2H)-thiophenone ≥98%, FG	W326607	250g	$793
4,5-Dihydro-3(2H)-thiophenone ≥98%, FG	W326607	1kg	$2870
4,5-Dihydro-3(2H)-thiophenone 98%	264784	25g	$38.8
4,5-Dihydro-3(2H)-thiophenone ≥98%, FG	W326607	1 unit	$56.3
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Tetrahydrothiophen-3-one Properties

Boiling point	175 °C(lit.)
Density	1.194 g/mL at 25 °C(lit.)
vapor density	>1 (vs air)
refractive index	n20/D 1.528(lit.)
FEMA	3266 \| 4,5-DIHYDRO-3(2H)THIOPHENONE
FLAVIS Number	15.012 \| 4,5-Dihydrothiophen-3(2H)-one
Flash point	171 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in DMSO
form	Liquid
Specific Gravity	1.194
color	Colorless to pale yellow
Odor	at 0.10 % in dipropylene glycol. garlic meaty green vegetables clams buttery
Odor Type	alliaceous
biological source	synthetic
JECFA Number	498
BRN	105201
Major Application	flavors and fragrances
InChI	1S/C4H6OS/c5-4-1-2-6-3-4/h1-3H2
InChIKey	DSXFPRKPFJRPIB-UHFFFAOYSA-N
SMILES	O=C1CCSC1
LogP	-0.29
CAS DataBase Reference	1003-04-9(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	4,5-DIHYDRO-3(2H)THIOPHENONE
FDA UNII	0E9MKH53DV
NIST Chemistry Reference	Dihydro-3-(2H)-thiophenone(1003-04-9)
EPA Substance Registry System	3(2H)-Thiophenone, dihydro- (1003-04-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-36/37/39

RIDADR

UN 3334

WGK Germany

8-13

Hazard Note

Irritant

TSCA

TSCA listed

HS Code

29349990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
2		0

Tetrahydrothiophen-3-one price More Price(78)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W326607	4,5-Dihydro-3(2H)-thiophenone ≥98%, FG	1003-04-9	1 each	$58	2026-04-30	Buy
Sigma-Aldrich	W326607	4,5-Dihydro-3(2H)-thiophenone ≥98%, FG	1003-04-9	250g	$793	2026-04-30	Buy
Sigma-Aldrich	W326607	4,5-Dihydro-3(2H)-thiophenone ≥98%, FG	1003-04-9	1kg	$2870	2026-04-30	Buy
Sigma-Aldrich	264784	4,5-Dihydro-3(2H)-thiophenone 98%	1003-04-9	25g	$38.8	2026-04-30	Buy
Sigma-Aldrich	W326607	4,5-Dihydro-3(2H)-thiophenone ≥98%, FG	1003-04-9	1 unit	$56.3	2025-07-31	Buy

Product number	Packaging	Price	Buy
W326607	1 each	$58	Buy
W326607	250g	$793	Buy
W326607	1kg	$2870	Buy
264784	25g	$38.8	Buy
W326607	1 unit	$56.3	Buy

Tetrahydrothiophen-3-one Chemical Properties,Uses,Production

Description

Tetrahydro-thiophene-3-one is a heterocyclic nonaromatic ketone. It has a garlic meaty, green vegetable, buttery odor. It is present in cooked beef, coffee, roast filbert, and roasted peanut.
Tetrahydro-thiophene-3-one is used as a food flavoring agent. It is also a valuable organic substance key that opens the synthetic access to numerous derivatives of thiophene.

Chemical Properties

4,5-Dihydro-3-(2H)thiophenone has a garlic meaty, green vegetable, buttery odor. It is a heterocyclic nonaromatic ketone.

Chemical Properties

Clear light yellow liquid

Occurrence

Reported found in cooked beef, coffee, roasted filberts and roasted peanuts.

Uses

4,5-Dihydro-3(2H)-thiophenone is a volatile organic sulfur compound (VOSC) produced by basidiomycetous yeasts.

Uses

Used for blending soft drinks, beverage, meat products, confectionery, and milk product flavors.

Preparation

From 4-methoxycarboxyl-3-oxothiophane treated with 10% sulfuric acid.

Taste threshold values

Taste characteristics at 15 ppm: onion, garlic, cooked meaty with vegetables nuances

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 2229, 1946 DOI: 10.1021/ja01215a034

References

[1] George A. Burdock (2010) Fenaroli's Handbook of Flavor Ingredients, Sixth Edition
[2] https://pubchem.ncbi.nlm.nih.gov
[3] Patent 0127121 A1: Process for the preparation of tetrahydro-thiophen-3-one

Tetrahydrothiophen-3-one synthesis

Synthesis of Tetrahydrothiophen-3-one from Thioglycolic acid and Acrylic acid

Tetrahydrothiophen-3-one Preparation Products And Raw materials

Raw materials

BENZHYDRYL ACETATE TETRAHYDRO-THIOPHEN-3-OL danosteine Methyl 4-oxotetrahydrothiophene-3-carboxylate Sulfuric acid

Preparation Products

3-methylthiolan-3-ol

Tetrahydrothiophen-3-one Suppliers

Global( 458)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HANGZHOU HAILAN CHEMICAL CO.,LTD.	+86-57156122185 +86-15967590394	sales@hailan-chem.com	China	2994	58
Shaanxi Didu New Materials Co. Ltd	+86-86-17392712697 +8617792793228	1069@dideu.com	China	8609	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
JINING XINHE CHEMICAL CO., LTD	+8615318402391	sales@xinhepharma.com	China	809	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55

Supplier	Advantage
HANGZHOU HAILAN CHEMICAL CO.,LTD.	58
Shaanxi Didu New Materials Co. Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
JINING XINHE CHEMICAL CO., LTD	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from Tetrahydrothiophen-3-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-05	Tetrahydrothiophen-3-one 1003-04-9		1kg	99%min	20tons	HANGZHOU HAILAN CHEMICAL CO.,LTD.
2026-05-15	Tetrahydrothiophen-3-one 1003-04-9	$1.50	1g	99.0% Min	100 Tons	Shaanxi Didu New Materials Co. Ltd
2026-05-11	Tetrahydrothiophen-3-one 1003-04-9	$34.00		99.23%	10g	TargetMol Chemicals Inc.

Tetrahydrothiophen-3-one
1003-04-9
$0.00
99%min
HANGZHOU HAILAN CHEMICAL CO.,LTD.

Tetrahydrothiophen-3-one
1003-04-9
$1.50
99.0% Min
Shaanxi Didu New Materials Co. Ltd

Tetrahydrothiophen-3-one
1003-04-9
$34.00
99.23%
TargetMol Chemicals Inc.

Tetrahydrothiophen-3-one Spectrum

Tetrahydrothiophen-3-one(1003-04-9)MS Tetrahydrothiophen-3-one(1003-04-9)¹HNMR Tetrahydrothiophen-3-one(1003-04-9)¹³CNMR Tetrahydrothiophen-3-one(1003-04-9)IR1 Tetrahydrothiophen-3-one(1003-04-9)Raman

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