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ChemicalBook >> CAS DataBase List >>4-Amino-6-chloro-5-methoxypyrimidine

4-Amino-6-chloro-5-methoxypyrimidine

4-Amino-6-chloro-5-methoxypyrimidine Structure
4-Amino-6-chloro-5-methoxypyrimidine structure
CAS No.
5018-41-7
Chemical Name:
4-Amino-6-chloro-5-methoxypyrimidine
Synonyms
6-CHLORO-5-METHOXYPYRIMIDIN-4-AMINE;6-Chloro-5-methoxy-4-pyrimidinamine;4-Amino-6-Chloro-5-Methoxy Pyrimidin;4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE;6-Chloro-5-MethoxypyriMidin-4-ylaMine;4-Pyrimidinamine, 6-chloro-5-methoxy-;4-Amino-6-chloro-5-methoxypyrimidine ISO 9001：2015 REACH;4-(p-AMinobenzene SulfonaMino)-5Methoxy-6-Chloro PyriMidine)
CBNumber:
CB8433466
Molecular Formula:
C5H6ClN3O
Molecular Weight:
159.57
MDL Number:
MFCD07787635
MOL File:
5018-41-7.mol
Last updated:2025-07-24 18:13:52
Product description Number Pack Size Price
4-Amino-6-chloro-5-methoxypyrimidine A595470 500mg $155
4-Amino-6-chloro-5-methoxypyrimidine L625 100mg $95
4-Amino-5-methoxy-6-chloropyrimidine 98% 101625 5g $374
4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE 95.00% HCH0012845 1G $970.2
4-Amino-5-methoxy-6-chloropyrimidine 98% 101625 25g $1170
More product size
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4-Amino-6-chloro-5-methoxypyrimidine Properties

Melting point 176-178 °C
Boiling point 305.4±37.0 °C(Predicted)
Density 1.398±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 1.51±0.10(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C5H6ClN3O/c1-10-3-4(6)8-2-9-5(3)7/h2H,1H3,(H2,7,8,9)
InChIKey AAJZJNHQPBMCFV-UHFFFAOYSA-N
SMILES C1=NC(Cl)=C(OC)C(N)=N1
CAS DataBase Reference 5018-41-7(CAS DataBase Reference)
FDA UNII XTV46J7E54

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H335-H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
HS Code  2933599590

4-Amino-6-chloro-5-methoxypyrimidine price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A595470 4-Amino-6-chloro-5-methoxypyrimidine 5018-41-7 500mg $155 2021-12-16 Buy
AK Scientific L625 4-Amino-6-chloro-5-methoxypyrimidine 5018-41-7 100mg $95 2021-12-16 Buy
Matrix Scientific 101625 4-Amino-5-methoxy-6-chloropyrimidine 98% 5018-41-7 5g $374 2021-12-16 Buy
American Custom Chemicals Corporation HCH0012845 4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE 95.00% 5018-41-7 1G $970.2 2021-12-16 Buy
Matrix Scientific 101625 4-Amino-5-methoxy-6-chloropyrimidine 98% 5018-41-7 25g $1170 2021-12-16 Buy
Product number Packaging Price Buy
A595470 500mg $155 Buy
L625 100mg $95 Buy
101625 5g $374 Buy
HCH0012845 1G $970.2 Buy
101625 25g $1170 Buy

4-Amino-6-chloro-5-methoxypyrimidine Chemical Properties,Uses,Production

Synthesis

4,6-Dichloro-5-methoxypyrimidine

5018-38-2

4-Amino-6-chloro-5-methoxypyrimidine

5018-41-7

General procedure for the synthesis of 4-sulfo-5-methoxy-6-chloropyrimidine from 4,6-dichloro-5-methoxypyrimidine: a mixture of 4,6-dichloro-5-methoxypyrimidine (5.0 g, 28.1 mmol), 30% ammonia (45 mL), and n-butanol (15 mL) was heated and reacted in a sealed tube for 8 hr at 85 °C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the concentrate was subsequently suspended in brine (150 mL). A white precipitate was collected by filtration and the filter cake was recrystallized from ethanol to afford the target compound 4-sulfo-5-methoxy-6-chloropyrimidine as an off-white solid in a yield of 4.1 g in 90% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.97 (s, 1H), 7.29 (s, 2H), 3.71 (s, 3H). Mass spectrum (ESI, cation mode) showed m/z: 159.91 [M + H]+.

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1148 - 1164
[2] Patent: CN108164548, 2018, A. Location in patent: Paragraph 0209; 0210; 0211
[3] Organic Process Research and Development, 2015, vol. 19, # 6, p. 639 - 645
[4] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 33

4-Amino-6-chloro-5-methoxypyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dichloro-5-methoxypyrimidine Ammonia tert-Butanol

Preparation Products

4-Pyrimidinamine, 5-methoxy- (9CI) 5-Pyrimidinol, 4-amino-6-chloro- (9CI)

4-Amino-6-chloro-5-methoxypyrimidine Suppliers

Global( 141)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29831 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Xiamen AmoyChem Co., Ltd 		58
Hubei xin bonus chemical co. LTD 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
SIMAGCHEM CORP 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from 4-Amino-6-chloro-5-methoxypyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-6-chloro-5-methoxypyrimidine pictures 2025-06-25 4-Amino-6-chloro-5-methoxypyrimidine
5018-41-7
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
4-Amino-6-chloro-5-methoxypyrimidine pictures 2019-07-10 4-Amino-6-chloro-5-methoxypyrimidine
5018-41-7
 US $8.80 / KG 1KG 97%-99% 100kg Career Henan Chemical Co

4-Amino-6-chloro-5-methoxypyrimidine Spectrum

4-Amino-6-chloro-5-methoxypyrimidine(5018-41-7)1HNMR

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6-CHLORO-5-METHOXYPYRIMIDIN-4-AMINE 4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE 4-Amino-6-Chloro-5-Methoxy Pyrimidin 6-Chloro-5-methoxy-4-pyrimidinamine 6-Chloro-5-MethoxypyriMidin-4-ylaMine 4-(p-AMinobenzene SulfonaMino)-5Methoxy-6-Chloro PyriMidine) 4-Pyrimidinamine, 6-chloro-5-methoxy- 4-Amino-6-chloro-5-methoxypyrimidine ISO 9001：2015 REACH 5018-41-7 Halogenated Heterocycles ,Imidazoles Heterocycle-Pyrimidine series Pyrimidine